Disease Information for Pyridostigmine (Mestinon) Administration/Toxicity

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Clinical Manifestations
Signs & Symptoms
Dizzy on Standing/Giddy Response
Orthostatic drop in blood pressure
Slow pulse/Bradycardia
Diarrhea
Diarrhea, explosive
Diarrhea, fulminant
Cholinergic symptoms/signs
Lacrimation/excess tearing
Night blindness/Impaired night vision
Pupil Response to Darkness Poor
Tearing
Typical Clinical Presentation
Coma with cholinergic ( SLUD) signs
Diagnostic Test Results
EKG (ECG)
EKG/Widened QRS pattern (ECG)
EKG/AV Nodal Block/Complete
EKG/Sinus bradycardia (ECG)
EKG/Changes/abnormalities (ECG)
Associated Diseases & Rule outs
Associated Disease & Complications
Bradyarrhythmias
Cardiac conduction defects
Cholinergic crisis/toxidrome
Heart block, complete
Orthostatic syncope Hypotension
Sinus bradycardia
Disease Mechanism & Classification
Drugs
DRUG/Acetylcholinesterase inhibitor
DRUG/Anti-Myasthenia Gravis medication (ex)
DRUG/Cholinergic agonist drug/effect (example)
DRUG/Enteric/gut motor stimulation
DRUG/Important Acute care drugs (example)
DRUG/Parasympatheticomemitic effect (ex)
DRUG/Lowers seizure threshold
Pathophysiology
Pathophysiology/Acetyl choline accumulation
Pathophysiology/Neuromuscular irritability
Process
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
Toxin
TOXIN/Decreases Heart Rate
TOXIN/SLUD response(sial/lacr/urine/dia)
Synonyms
Synonym
3 (((Dimethylamino)carbonyl)oxy) 1 methylpyridinium Bromide, 3 Hydroxy 1 methylpyridinium Bromide Dimethylcarbamate, Bromide Pyridostigmine, Carbamic Acid Dimethyl Ester with 3 Hydroxy 1 methylpyridinium Bromide, Kalimin, Mestinon Bromide, Pyridinium 3 (((dimethylamino)carbonyl)oxy) 1 methyl bromide, Pyridostigmine Bromide, Pyridostigmine bromide (dup) (substance), Pyridostigmine bromide (substance), PYRIDOSTIGMINE BROMIDE PREPARATION, Regonal, Brand name/Mestinon (Pyridostigmine)
Treatment
Drug Dosage
DRUG/.$$$ Expensive medication
DRUG/Dose 60 mgm (Unit/Pill/Capsule size)
DRUG/Dose BID Medication
DRUG/Dose Extended time release/XT/SA (example)
DRUG/Injectable medication (parenteral)
DRUG/Injectable preparation only
DRUG/Oral medication (ex)
Definition

ACHase Inhibitor drug; Anticholinesterase inhibitor used in

myasthenia gravis treatment; This is an Oral drug; ACHase inhibitors can cause cholinergic crisis

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External Links Related to Pyridostigmine (Mestinon) Administration/Toxicity
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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