Disease Information for Pyoderma gangrenosa

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Clinical Manifestations
Signs & Symptoms
Facial ulceration/ulcers
Red/erythema skin discoloration
Cutaneous granulomatous ulceration/signs
Cutaneous ulcer/Skin ulcer
Cutaneous ulcers/boggy red irregular borders
Cutaneous ulcers/necrotic purulent base/center
Cutaneous ulcers/purulent base
Cutaneous ulcers/under-cut border
Delayed/poor wound healing
Encrusting Skin Lesions
Erythroderma
Hyperpathia phenomenon (venipuncture inf)
Leg Ulcers in Children
Leg Ulcers in Elderly
Necrotic Insect/Spider Bite/Central Ulcer
Painful skin ulcer
Red/blue skin ulcers/irregular borders/multiple
Residual Scars lower extremity lesions
Skin pathergy/needle stick/sterile pustule/erythema
Skin Ulcer with Eschar
Sores/weeping sores skin/extremity
Ulcer/skin 'punched out' type
Chronically ill patient/signs
Clinical Presentation & Variations
Presentation/Painful Leg Ulcer Chronic
Disease Progression
Course/Chronic disorder
Course/Chronic only
Course/Persistent/symptoms possible
Course/Progressive
Course/Relentless
Demographics & Risk Factors
Established Disease Population
Patient/Inflammatory Bowel Disease
Patient/Ulcerative colitis
Laboratory Tests
Microbiology & Serology Findings
Microlab/Cutaneous ulcer/lesion culture abnormal
Microlab/Skin scraping lesions/bacteria on stain
Diagnostic Test Results
Pathology
BX/Skin biopsy/Abnormal
BX/Skin biopsy/Dermis infiltrate/neutrophiles
BX/Skin/Acute Inflammation Polys
PATH/Tissue neutrophiles/microabscessing/necrosis
Associated Diseases & Rule outs
Rule Outs
Anthrax
Cellulitis
Cutaneous Blastomycosis
Decubitus ulcer/Bedsores
Impetigo/Pyoderm
Spider bite, Brown Recluse
Sporotrichosis
Associated Disease & Complications
Cutaneous Infection
Decubitus ulcer/Bedsores
PAPA syndrome
Pyoderma gangrenosa
Ulceroglandular syndrome
Granulomatous Dermatitis
Leg ulcers
Disease Mechanism & Classification
Class
CLASS/Cellular Immune System Disorder (ex)
CLASS/Dermatologic/Subcutaneous (category)
CLASS/Skin disorder (ex)
Pathophysiology
Pathophysiology/Granulomatous skin areas/lesions
Pathophysiology/Ulcer/Dermatologic disorder (ex)
Pathophysiology/Activated cellular immunopathology
Pathophysiology/Immune physiology/defective
Pathophysiology/Immune/cellular system disorder (ex)
Process
PROCESS/Allergy/collagen/autoimmune (category)
PROCESS/Allergy/inflammatory/granulomatous disorder (ex).
PROCESS/Infected organ/abscess (category)
PROCESS/Reference organ/system (category)
Synonyms
Synonym
gangrenosum pyoderma, Pyoderma gangenosum, PYODERMA GANGRENOSA, Pyoderma gangrenosum, Pyoderma gangrenosum (disorder), PYODERMA GANGRENOUS, Synonym/Bullous Pyoderma Gangenosa, Synonym/Necrotizing subcutaneous infection, Synonym/Pustular Pyoderma Gangenosa, Synonym/Vegetative Pyoderma Gangenosa
Treatment
Drug Therapy - Indication
RX/Anakinra (Kineret)
RX/Ciclosporine Cyclosporin (Sandimmune)
RX/Corticosteroid (Cortisone)
RX/Infliximab (Remicade)
RX/Mycophenolate mofetil (MMF)
RX/Tacrolimus (Prograf)
RX/Thalidomide (Thalomid)
Surgical Procedures or Treatments
SX/Biopsy
Surgical Procedures or Treatments
SX/Biopsy
Other Treatments
TX/Plasmapheresis/exchange.
Definition

An idiopathic, rapidly evolving, and severely debilitating disease occurring most commonly in association with chronic ulcerative colitis. It is characterized by the presence of boggy, purplish ulcers with undermined borders, appearing mostly on the legs. The majority of cases are in people between 40 and 60 years old. Its etiology is unknown.

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External Links Related to Pyoderma gangrenosa
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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