Disease Information for Protein losing enteropathy

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Clinical Manifestations
Signs & Symptoms
Edema Children
Bilateral ankle swelling
Bilateral leg edema/swelling
Acute Diarrhea
Acute Diarrhea in Children
Chronic Diarrhea in a Child
Diarrhea
Diarrhea in Children
Diarrhea, chronic
Diarrhea/painless
Poor weight gain/child
Edema of Lower Extremities
Swelling all extremities
Dullness to percussion lung base
Localized dullness to percussion
Lung signs/abnormality
Growth/development delay
Neonatal edema/anasarca
Weight gain
Bilateral Eyelid Edema
Periorbital edema/Puffy eyes
Demographics & Risk Factors
Population Group
Child
Population/Pediatrics population
Sex & Age Groups
Population/Child
Population/Children/all
Laboratory Tests
Abnormal Lab Findings - Decreased
Albumin, serum (Lab)
Alpha-1-antitrypsin globulin level (Lab)
Calcium, serum (Lab)
Cholesterol (Lab)
Copper, serum (Lab)
Gamma globulin (Lab)
Globulin, serum (Lab)
Hematocrit (Lab)
Hemoglobin (Lab)
IGA/Immunoglobulin A (Lab)
IGG/Immunoglobulin G (Lab)
IGM/Immunoglobulin M (Lab)
Prealbumin levels (labs)
RBC/Red Blood Count (Lab)
Thyroid Binding Globulin (Lab)
Thyroxin/T4 (Lab)
TIBC/Total Iron Binding capacity (Lab)
Total Protein, serum (Lab)
Abnormal Lab Findings - Increased
IGG/Immunoglobulin G (Lab)
STOOL Alpha-trypsin/quantitative
Diagnostic Test Results
Other Tests & Procedures
TEST/D-Xylose absorption abnormal
Pathology
BX/Intestinal biopsy/Dilated lymphatics
BX/Intestinal biopsy/ileum/ abnormal
Isotope Scan
Isotope/Tagged I-131/albumin injection/fecal increased.
Isotope/Tagged PVP injection/fecal increase
X-RAY With contrast
SBS/Mucosal folds thickened, intestinal (Xray)
SBS/Valvulae conniventes thickened (Xray)
UGI/Duodenum thickened folds
Associated Diseases & Rule outs
Rule Outs
Hypocalcemia
Hypogammaglobulinemia
Associated Disease & Complications
Anemia
Ascites
Edema
Growth retardation/failure
Hypoalbuminemia Hypoproteinemia
Hypogammaglobulinemia
Hypogammaglobulinemia, acquired
Intestine involvement/manifestaion
Malnutrition/Starvation
Peritoneal Effusion
Primary protein losing enteropathy/lymphectasia
Protein losing enteropathy
Disease Mechanism & Classification
Class
CLASS/Pediatric disorders (ex)
CLASS/Intestinal disorder (ex)
CLASS/Intestinal/stomach/gut (category)
Pathophysiology
Pathophysiology/Protein leak into gut
Pathophysiology/Hypercatabolism/IGG/Gamma globulin
Process
PROCESS/Reference organ/system (category)
PROCESS/Vegetative-Autonomic/Endocrine (category)
Synonyms
Synonym
gastroenteropathy protein losing, Protein losing gastroenteropathy, Synonym/Enteropathy, hypercatabolic protein losing, Synonym/Enteropathy, lymphangectatic protein losing, Synonym/Gordon's enteropathy/lymphangiectasia, Synonym/Intestinal lymphangectasia, Synonym/Lymphangectasia, intestinal
Treatment
Other Treatments
TX/Diet restriction treatment.
TX/Medium chain triglycerides/diet limit
Definition

Patients with protein-losing enteropathy due to lymphatic obstruction, however, lose not only albumin and other plasma proteins but also intestinal lymph, with loss of long-chain triglycerides, fat-soluble vitamins and small lymphocytes; Protein-losing enteropathy is considered in patients who exhibit hypoproteinemia and in whom other causes for hypoproteinemia (eg, proteinuria, protein malnutrition and liver disease) are excluded; Fecal protein loss can then be quantitated using 51Cr-labeled albumin or a1-antitrypsin clearance into stool; Enteric protein loss in patients with intestinal lymphangiectasia usually decreases with a low-fat diet; The normal absorption of long-chain triglycerides stimulates intestinal lymph flow; in their absence there is a decrease in the pressure within intestinal lymphatic vessels and hence a diminished loss of lymph into the lumen; Medium-chain triglycerides, which do not require intestinal lymphatic transport, can be substituted for the long-chain triglycerides and further decrease intestinal lymphatic pressure, with subsequent reduction in enteric lymph and protein loss --------------[First principles of gastroenteroplogy website 2005 Thomson and Shaffer ]

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External Links Related to Protein losing enteropathy
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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