Disease Information for Propylthiouracil (PTU) Administration/Toxicity

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Clinical Manifestations
Signs & Symptoms
Enlarged thyroid gland
Goiter/thyroid enlargement/mass
Thyroid Mass
Thyromegaly/Symmetric enlargement
Parotid swelling
Salivary Gland Enlargement
Laboratory Tests
Abnormal Lab Findings - Increased
Anti-MPO titer (P-ANCA)/Myeloperoxidase antibody (Lab)
Diagnostic Test Results
Isotope Scan
Isotope/RAI Uptake low/thyroid scan (I 123)
Isotope/RAI uptake/quantitative high thyroid (I 123)
Associated Diseases & Rule outs
Associated Disease & Complications
Agranulocytosis
Alveolar hemorrhage syndrome
Drug induced Hepatic toxicity
Drug induced Neutropenia.
Drug induced Pleural effusion
Granulocytopenia/Neutropenia
Hypothyroidism (myxedema)
Pericardial effusion
Toxic hepatitis
Disease Mechanism & Classification
Drugs
DRUG/Anti-thyroid medication (example)
DRUG/Antithyroid thionamide medication
DRUG/Blocks organification of iodine/thyroid
DRUG/Breast milk secretion/Danger
DRUG/Decrease peripheral T4 to T3 conversion
DRUG/Teratogenic potential/effect (D plus )
Pathophysiology
Pathophysiology/Defective thyroid hormone biosynthesis
Process
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
Synonyms
Synonym
4(1H) Pyrimidinone 2 3 dihydro 6 propyl 2 thioxo, 6 Propyl 2 Thiouracil, PROPYLTHIOURACIL, Propylthiouracil (product), Propylthiouracil (substance), Propylthiouracil preparation, Propylthiouracil product, PTU preparation, Brand name/PTU (Propylthiouracil)
Treatment
Drug Therapy - Contraindication
RX/Warfarin (Coumadin)
Drug Dosage
DRUG/.1990 or before
DRUG/Dose 50 mgm (Unit/Pill/Capsule size)
DRUG/Dose QID Medication
DRUG/Generic available
DRUG/Oral medication (ex)
Definition

Anti-thyroid drug; prevents thyroxin formation and release

from thyroid gland

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External Links Related to Propylthiouracil (PTU) Administration/Toxicity
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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