Disease Information for Propoxyphene (Darvon/Dolene) TOXIC Administration/Toxicity

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Clinical Manifestations
Signs & Symptoms
Hypotension with Relative Bradycardia
Low Blood Pressure
Slow pulse/Bradycardia
Laboratory Tests
Abnormal Lab Findings - Increased
Potassium, serum (Lab)
Diagnostic Test Results
EKG (ECG)
EKG/Widened QRS pattern (ECG)
EKG/AV Nodal Block/Complete
EKG/Changes/abnormalities (ECG)
Associated Diseases & Rule outs
Rule Outs
Digitalis toxicity/poisoning
Associated Disease & Complications
Bradyarrhythmias
Cardiac arrhythmias
Cardiac conduction defects
Drug induced Nephritis/Nephropathy
Heart block, complete
Hypotension
Nephritis, analgesic/interstitial
Nephritis, interstitial
Nephritis, non-allergic interstitial
Nephritis, secondary
Opiate/Morphine overdose toxidrome
Toxic nephritis/Chronic persistent
Toxic Nephritis/Nephropathy
Disease Mechanism & Classification
Drugs
DRUG/Active metabolites
DRUG/Analgesic/non-narcotic drug (example)
DRUG/Drug tolerance/effect
DRUG/Narcotic/analgesic drug (category)
DRUG/Narcotic/Opiate-opioid medication (example)
DRUG/Synthetic opioid agonist (example)
Process
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
Toxin
TOXIN/Hypotension relative bradycardia
Synonyms
Synonym
Benzeneethanol alpha (2 (dimethylamino) 1 methylethyl) alpha phenyl propanoate (ester) (S (R* S*)), D Propoxyphene, Dextropropoxyphene, Dextropropoxyphene (product), Dextropropoxyphene (substance), PROPOXYPHENE, Propoxyphene (substance), PROPOXYPHENE D, PROPOXYPHENE PREPARATION, Proxyphen, Brand name/Darvocet-N (Propoxephene-Acetaminophen), Brand name/Darvon (Propoxyphen), Brand name/Dolene (Propoxyphen), Brand name/Wygesic (Propoxyphen) combination
Treatment
Drug Dosage
DRUG/Drug discontinued/TOXIC (RX)
Definition

Synthetic opiod weak analgesic narcotic drug with potential for respiratory depression; proarrhythmic metabolite; oral preparation; not hemodialyzable; long half-life

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External Links Related to Propoxyphene (Darvon/Dolene) TOXIC Administration/Toxicity
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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