Disease Information for Pramipexole (Mirapex) Administration/Toxicity

Clinical Manifestations
Signs & Symptoms
Behavior problems
Nightmares/excess dreaming (Paroniria)
Associated Diseases & Rule outs
Associated Disease & Complications
Drug induced Dreaming/nightmares (Paroniria)
Neurobehavior Problems
Disease Mechanism & Classification
DRUG/Anti-multiple sclerosis medication (example)
DRUG/Anti-parkinsons medication (examples)
DRUG/Dopamine agonist/CNS drug (example)
DRUG/Dopamine D2 receptor only/agonist
DRUG/Dopamine Receptor agonist/CNS
DRUG/Dopaminergic Anti-Parkinson's medication
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
Pramipexole (Mirapex) admin, Brand name/Mirapex (Pramipexole)
Drug Dosage
DRUG/.$$$$ Very Expensive
DRUG/Dose 1 mgm (Unit/Pill/Capsule size)
DRUG/Dose 1.25 mgm (Unit/Pill/Capsule size)
DRUG/Dose once daily (RX)
DRUG/Oral medication (ex)

Anti-parkinsonism drug; Dopamine agonist non-ergot type; levodopa sparing drug; causes orthostatic hypotension hallucinations and drowsiness; avoid abrupt withdrawal; oral preparation once daily ; possibly this class of drugs shown to be a trigger for new addictive behavior for food, gambling, sex, with other behavior issues [2005] -----------------------------------------------------

Pramipexole and ropinirole are two newer dopamine agonists that are not ergot derivatives; They are effective in early Parkinson"s disease as well as in advanced stages of the disease; In each case, the daily dose is built up gradually; Pramipexole is started at a dosage of 0_125 mg three times daily, and the dose is doubled after 1 week and again after another week; the daily dose is then increased by 0_75 mg at weekly intervals depending on response and tolerance; Most patients require between 0_5 and 1_5 mg three times daily; Adverse effects include fatigue, somnolence, nausea, peripheral edema, dyskinesias, confusion, and postural hypotension; Less commonly, an irresistible urge to sleep may occur, sometimes in inappropriate and hazardous circumstances--------[currentdxrx 2005 accessmedicine_com]---------


External Links Related to Pramipexole (Mirapex) Administration/Toxicity
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)