Disease Information for Postpartum pituitary Necrosis

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Clinical Manifestations
Signs & Symptoms
Agalactia/Lactation failure
Breast atrophy
Lactation suppression/nursing mother/complaint
Absent pubic/axillary hair
Axillary hair loss
Thin skin/parchment-like skin
Sexual dysfunction
Small testes
Small/soft testes
Bitemporal hemianopsia
Fatigability
Headache, sudden severe and new type/Thunderclap
Amenorrhea
Amenorrhea, secondary
Anorgasmia/Orgasm Dysfunction
Anorgasmic Female
Loss of libido,women
Depressed/discouraged/sad
Fatigue
Fatigue Tiredness Exhaustion
Low body temperature
Difficulty Focusing Eyes
Diplopia Double vision
Disease Progression
Course/Acute
Course/Chronic disorder
Demographics & Risk Factors
Past History
Past history/Postpartum vascular collapse/shock
Established Disease Population
Patient/Acromegaly
Sex & Age Groups
Population/Adult Aged Only
Population/Adult/all
Laboratory Tests
Abnormal Lab Findings - Decreased
ACTH/Corticotrpin/Adrenocortical Hypertrophic hormone (Lab)
Cortisol (Lab)
Estradiol Serum (Lab)
FSH/Follicle Stmulating Hormone/ICSH (Lab)
FTI/Free Thyroxin Index (Lab)
LH/Leutinizing Hormone (Lab)
Prolactin (Lab)
Tri-iodothyronine/T3 as Resin Uptake (Lab)
URINE 17-Hydroxycorticosteroids
URINE 17-Ketosteroids
URINE Cortisol/Free Cortisol
URINE Estrogens
URINE Free Cortisol/24 Hour
URINE FSH
URINE Growth hormone
URINE Leutininzing hormone
URINE/Estradiol (Lab)
URINE/Estratriol (Lab)
Diagnostic Test Results
Other Tests & Procedures
Test/Cotrysin Pituitary Stimulation Abnormal
Visual fields/Bitemporal visual field defects
TEST/Growth Hormone Stimulation (Arginine/Insulin)Abnormal
CT Scan
CT Scan/Head Empty sella syndrome
MRI/Head Scan Abnormal
Associated Diseases & Rule outs
Rule Outs
Craniopharyngioma
Optic neuritis
Associated Disease & Complications
Adrenal insufficiency/hypopituitary/ACTH deficiency
Adrenocortical insufficiency
Anorchia/Hypoplasia testes
Central diabetes insipidus
Dysfunctional Uterine Bleeding
Early menopause
Empty sella syndrome
Glucocorticoid Deficiency
Gonadotropin deficiency/Female acquired
Hypogonadism, male
Hypovolemia
Infertility/sterility, female
Ovarian Dysfunction
Panhypopituitarism
Pituitary hypothyroidism
Postpartum pituitary necrosis
Secondary female hypogonadism
Testicular atrophy
Anovulatory Cycles
Disease Mechanism & Classification
Class
CLASS/Endocrine gland (category)
CLASS/Pituitary gland involvement/disorder (ex)
Pathophysiology
Pathophysiology/Hypogonadotrophic hypogonadism
Pathophysiology/Chronic anovulation
Pathophysiology/Hypoestrogenic Anovulation
Pathophysiology/Ovarian dysfunction anovulation
Process
PROCESS/Arteriosclerosis/vascular/venous (category)
PROCESS/Complicating disorder (ex)
PROCESS/Ischemic process (ex)
PROCESS/Necrosis (ex)
PROCESS/Reference organ/system (category)
PROCESS/Use/Age/atrophic disorder (category)
Synonyms
Synonym
Disease Simmonds, Hypopituitarism Postpartum, Ischaemic postpartum pituitary necrosis, Ischemic postpartum pituitary necrosis, Ischemic postpartum pituitary necrosis (disorder), Panhypopituitarism Postpartum, Pituitary Insufficiency Postpartum, Postpartum hypopituitarism, Postpartum hypopituitarism (disorder), Postpartum necrosis of pituitary, Postpartum Panhypopituitarism, postpartum panhypopituitarism syndrome, Postpartum panhypopituitary syndrome, POSTPARTUM PITUITARY HEMORRHAGE, Postpartum pituitary infarction, Postpartum Pituitary Insufficiency, Postpartum pituitary necrosis, Postpartum pituitary necrosis syndrome, Reye Sheehan syndrome, Sheehan, Sheehan Syndrome, Sheehans Syndrome, Sheehan's Syndrome, Sheehan's syndrome (disorder), SIMMONDS DIS, Simmonds Disease, Simmond's Disease, Simmonds' Disease, syndrome postpartum panhypopituitary, Syndrome Sheehan, Syndrome Sheehan's, Synonym/Hypopituitarism, postpartum, Synonym/Postpartum panhypopituitary syndrome, Synonym/Sheehan syndrome
Definition

Sudden hemorrhage or ischemic necrosis involving the pituitary gland which may be associated with acute visual loss, severe headache, meningeal signs, cranial nerve palsies, panhypopituitarism, and rarely COMA; The most common cause is hemorrhage (INTRACRANIAL HEMORRHAGES) related to a pituitary ADENOMA; Ischemia; MENINGITIS; INTRACRANIAL HYPERTENSION; and other disorders may be associated with this condition----------------------------------Sheehan Syndrome; Postpartum Hypopituitarism;

Postpartum Panhypopituitarism;Postpartum Panhypopituitary Syndrome; Postpartum Pituitary Necrosis; Simmond"s Disease

Sheehan Syndrome (SS) arises, subsequent to the birth of a baby, because of damage to the pituitary gland that results in a reduced output of the hormones and other products produced by that endocrine gland (hypopituitarism); The pituitary gland is made up of anterior and posterior portions, and the anterior part is particularly vulnerable to the shock that may result from the loss of blood during delivery; The pituitary is a small gland, located deep in the brain, that produces many of the hormones that control essential bodily processes; During pregnancy, the pituitary gland grows to about double its normal size and is susceptible to postpartum complications; If tissue in the anterior pituitary dies because of postpartum hemorrhaging, the hormonal balance of the body is thrown completely out of equilibrium with consequences that show up as symptoms of Sheehan Syndrome; The chronic form presents months to years later, while the even more rare acute form shows up shortly after delivery-------[NORD website 2005]----------------

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External Links Related to Postpartum pituitary Necrosis
Google
Wikipedia
Merck
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PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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