Disease Information for Pituitary adenoma, ACTH secreting

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Clinical Manifestations
Signs & Symptoms
Plethora/Red face/Ruddy look
Acne flare
Brown skin discoloration
Bruising/Ecchymosis
Hirsutism
Hypertrichosis
Increased pigmentation/tanning/hyperpigmented
Striae/Purple striae
Thin skin/parchment-like skin
Buffalo hump
Cushingoid habitus
Male body habitus/female
Moon-like facies
Virilism
Loss of libido,male
Sexual dysfunction
Excessive/easy bruising tendency
Renal Mass
Muscle weakness
Proximal lower extremity weakness
Bitemporal hemianopsia
Amenorrhea
Oligomenorrhea/Hypomenorrhea
Polymenorrhagia
Tall child
Kidney Mass
Truncal obesity
Weakness
Weight gain
Clinical Presentation & Variations
Presentation/Hypertension Abrupt Onset
Disease Progression
Course/Chronic disorder
Course/Chronic only
Demographics & Risk Factors
Family History
Family history/MEA/endocrine tumors
Laboratory Tests
Abnormal Lab Findings - Decreased
Chloride serum (Lab)
Potassium, serum (Lab)
Abnormal Lab Findings - Increased
ACTH/Corticotrpin/Adrenocortical Hypertrophic hormone (Lab)
Cortisol (Lab)
Dehydroepiandrosterone S (DHEAS) (Lab)
Sodium, serum (Lab)
URINE Cortisol/Free Cortisol
URINE Free Cortisol/24 Hour
Diagnostic Test Results
Other Tests & Procedures
TEST/Decadron suppression abnormal
Visual Fields Test Abnormal
Visual fields/Bitemporal visual field defects
Pathology
PATH/Adrenocortical hypertrophy
CT Scan
CT Scan/Adrenal mass
CT Scan/Adrenal Mass Bilateral
Image Scan/Unilateral Adrenal mass
MRI/Adrenal mass/Abdomen
MRI/Bilateral Adrenal Masses/abdomen
CT Scan/Head Brain Abnormality
CT Scan/Head Enlarged pituitary gland
MRI/Head enlarging pituitary gland
MRI/Head Scan Abnormal
X-RAY
Xray/Enlarged sella/Head
Xray/Enlarging sella turcica
Associated Diseases & Rule outs
Rule Outs
Carcinoma, adrenal cortex
Cushing's disease/Syndrome
Cushings, iatrogenic syndrome
Ectopic ACTH production syndrome
Associated Disease & Complications
Acne vulgaris (acne)
Cushing's disease/Syndrome
Diabetes mellitus
Encephalopathy, hypertensive
Endocrine adenomata, multiple, type 1/MEA 1
Hyperglycemia
Hypernatremia
Hyperpigmentation
Hypertension
Hypertension, secondary
Hypokalemia
Hypokalemic nephropathy
Hypophosphatemia
Multiple endocrine adenomata/hereditary
Nelson syndrome/ACTH secreting pituitary tumor
Peptic ulcer disease
Pituitary adenoma, ACTH secreting
Pituitary Cushings syndrome
Pituitary tumors
Psychosis
Sellar tumor/suprasellar extension
Diabetes mellitus/non-insulin dep/type II
Disease Mechanism & Classification
Class
CLASS/Adrenal gland disorders (ex).
CLASS/Endocrine gland (category)
CLASS/Pituitary gland involvement/disorder (ex)
CLASS/Brain/CNS disorder (ex)
Pathophysiology
Pathophysiology/Enlarging pituitary gland
Process
PROCESS/Benign tumor (ex).
PROCESS/Endocrine/humoral disorders (category)
PROCESS/Neoplastic (category)
PROCESS/Endocrine adenoma (ex).
Synonyms
Synonym
ACTH Producing Pituitary Adenoma, ACTH Producing Pituitary Adenomas, ACTH Producing Pituitary Gland Adenoma, ACTH secreting adenoma, ACTH Secreting Adenoma of Pituitary, ACTH Secreting Adenoma of Pituitary Gland, ACTH Secreting Adenoma of the Pituitary, ACTH Secreting Adenoma of the Pituitary Gland, ACTH secreting pitu adenoma, ACTH Secreting Pituitary Adenoma, ACTH Secreting Pituitary Adenomas, ACTHoma, adenoma ACTH secreting, Adenoma Corticotroph, Adenomas Corticotroph, Adrenocorticotropin Producing Adenoma of Pituitary, Adrenocorticotropin Producing Adenoma of Pituitary Gland, Adrenocorticotropin Producing Adenoma of the Pituitary, Adrenocorticotropin Producing Adenoma of the Pituitary Gland, Adrenocorticotropin Producing Pituitary Adenoma, Adrenocorticotropin Producing Pituitary Gland Adenoma, Adrenocorticotropin Secreting Adenoma of Pituitary, Adrenocorticotropin Secreting Adenoma of Pituitary Gland, Adrenocorticotropin Secreting Adenoma of the Pituitary, Adrenocorticotropin Secreting Adenoma of the Pituitary Gland, Adrenocorticotropin Secreting Pituitary Adenoma, Adrenocorticotropin Secreting Pituitary Gland Adenoma, BRAIN TUMOR ACTH SECRETING PITUITARY ADENOMA, Corticotroph Adenoma, Corticotroph adenoma (disorder), Corticotroph Adenomas, Corticotropin Secreting Adenoma of the Pituitary, Corticotropin Secreting Adenoma Pituitary, Corticotropin Secreting Adenomas Pituitary, Corticotropin Secreting Pituitary Gland Adenoma, Corticotropinoma, INTRACRANIAL NEOPLASM ACTH SECRETING PITUITARY ADENOMA, Pituitary ACTH Secreting Adenoma, Pituitary Adenoma ACTH Producing, Pituitary Adenoma ACTH Secreting, Pituitary Adenomas ACTH Producing, Pituitary Adenomas ACTH Secreting, Pituitary Corticotropin Secreting Adenoma, Pituitary Corticotropin Secreting Adenomas, Pituitary Gland ACTH Secreting Adenoma, Synonym/Pituitary Cushings syndrome/disease
Treatment
Drug Therapy - Indication
RX/Ketoconazole (Nizoral)
RX/Metyrapone (Metopirone)
RX/Octreotide (Sandostatin)
Other Treatments
TX/Brain radiation.
Definition

A benign tumor, usually found in the anterior lobe of the pituitary gland, whose cells stain with acid dyes. Such pituitary tumors may give rise to excessive secretion of growth hormone, resulting in gigantism or acromegaly. A specific type of acidophil adenoma may give rise to nonpuerperal galactorrhea. (Dorland, 27th ed)

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External Links Related to Pituitary adenoma, ACTH secreting
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PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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