Disease Information for Pick disease

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Clinical Manifestations
Signs & Symptoms
Abulia status/inert/no motivation
Anomia
Apathy/Indifference
Basal ganglion signs
CNS symptoms/signs
Cognitive defect
Delirium
Frontal lobe signs
Impaired judgement/signs
Inattention
Near recall/memory deficit/defect
Paucity of ideas/conversation
Personality change
Poverty of thought
Scattered thought process
Urine Incontinence
Listlessness/lassitude
Disease Progression
Course/Chronic disorder
Course/Chronic only
Diagnostic Test Results
Pathology
PATH/Hyperphosphorylated Tau microtubule deposits
Pathophysiology/Tauopathy (Tau positive deposits) CNS
Associated Diseases & Rule outs
Rule Outs
Alzheimers disease
Dementia, Lewy body type
Associated Disease & Complications
Amnesia
Dementia
Organic brain syndrome
Disease Mechanism & Classification
Class
CLASS/Brain/CNS disorder (ex)
CLASS/Neurologic (category)
Process
PROCESS/Eponymic (category)
PROCESS/Use/Age/atrophic disorder (category)
Definition

A rare form of DEMENTIA that is sometimes familial; Clinical features include APHASIA; APRAXIA; CONFUSION; ANOMIA; memory loss; and personality deterioration; This pattern is consistent with the pathologic findings of circumscribed atrophy of the poles of the FRONTAL LOBE and TEMPORAL LOBE; Neuronal loss is maximal in the HIPPOCAMPUS, entorhinal cortex, and AMYGDALA; Some ballooned cortical neurons contain argentophylic (Pick) bodies; (From Brain Pathol 1998 Apr;8(2):339-54; Adams et al, Principles of Neurology, 6th ed, pp1057-9); a young form of Alzheimers often familial; Pick"s disease is a relatively rare, degenerative brain illness that causes dementia; The first description of the disease was published in 1892 by Arnold Pick; Until recently it was thought that Pick"s disease could not be distinguished from Alzheimer"s disease during life; Consequently, it has been little studied, and much less is known about it than about Alzheimer"s disease; Pick"s disease differs from Alzheimer"s disease in several ways; First, the two diseases produce different abnormalities in the cells of the brain; Pick"s disease is marked by "Pick bodies", rounded, microscopic structures found within affected cells; Neurons swell, taking on a "ballooned" appearance; Neither of these changes appears in Alzheimer"s disease, and the pathology of Alzheimer"s disease (plaques and tangles) is not found in Pick"s disease; Secondly, Pick"s disease is usually sharply confined to the front parts of the brain, particularly the frontal and anterior temporal lobes; This contrasts with Alzheimer"s disease, which is more widely distributed; The two diseases also produce different neurochemical changes in the brain; These basic differences between Alzheimer"s disease and Pick"s disease mean that the two tend to produce somewhat different symptoms; In contrast to Alzheimer"s disease, in which early memory loss predominates, the first symptoms of Pick"s disease are often personality change, and a decline in function at work and home; Personality change may take the form of apathy and indifference toward customary interests, or of disregard for social decorum and for the feelings of others; Poor social judgement, inappropriate sexual advances, or a coarse and jocular demeanor may be seen; Function declines because the patient simply does very little, or displays confusion and poor judgement; Patients may not be highly forgetful; Often times the patient performs well when directed to do something, but cannot undertake the very same thing independently; What is lost is the ability to initiate, organize, and follow through on even very simple plans and familiar activities;

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External Links Related to Pick disease
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PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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