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- Disease Information
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Disease Information for Physostigmine (Eserine/Antlirium) Administration/Toxicity
- Clinical Manifestations
- Signs & Symptoms
- Dizzy on Standing/Giddy Response
- Low Blood Pressure
- Orthostatic drop in blood pressure
- Regional pallor/vasospasm
- Slow pulse/Bradycardia
- Vasospasm of extremities/Signs
- Diaphoresis profuse/active sweating/acute
- Hyperhidrosis/Chronic sweating excess
- Sweating Excess Perspiration
- Abdominal Pain
- Active Bowel Sounds
- Borborygmi/Bowel sound increased
- Colicky Abdominal Pain
- Diarrhea
- Diarrhea, explosive
- Diarrhea, fulminant
- Loss of bowel control/incontinence acute
- Nausea
- Vomiting
- Seizures
- Bronchospasm signs
- Wheezing
- Cholinergic symptoms/signs
- Infrequent blinking/Stellwag sign
- Lacrimation/excess tearing
- Miosis/narrow pupils
- Tearing
- Typical Clinical Presentation
- Coma with cholinergic ( SLUD) signs
- Laboratory Tests
- Abnormal Lab Findings - Increased
- Acetyl choline level (Lab)
- Diagnostic Test Results
- EKG (ECG)
- EKG/Widened QRS pattern (ECG)
- EKG/AV Nodal Block/Complete
- EKG/Sinus bradycardia (ECG)
- EKG/Sinus pause (ECG)
- EKG/Changes/abnormalities (ECG)
- Associated Diseases & Rule outs
- Associated Disease & Complications
- Asthma
- Brady-arrhythmia
- Bradyarrhythmias
- Cardiac conduction defects
- Cholinergic crisis/toxidrome
- Convulsions (grand mal)
- Heart block, complete
- Hypotension
- Orthostatic syncope Hypotension
- Sinus bradycardia
- Disease Mechanism & Classification
- Drugs
- DRUG/Acetylcholinesterase inhibitor
- DRUG/Antidote/specific medication (example)
- DRUG/Anti-Myasthenia Gravis medication (ex)
- DRUG/Cholinergic agonist drug/effect (example)
- DRUG/Important Acute care drugs (example)
- DRUG/Parasympatheticomemitic effect (ex)
- DRUG/Lowers seizure threshold
- Pathophysiology
- Pathophysiology/Acetyl choline accumulation
- Pathophysiology/Peristalsis increased
- Pathophysiology/Neuromuscular irritability
- Pathophysiology/Bronchospasm
- Process
- PROCESS/Medication/Drug (CONFIRM dose/before treatment)
- Toxin
- TOXIN/Decreases Heart Rate
- TOXIN/SLUD response(sial/lacr/urine/dia)
- Synonyms
- Synonym
- physostigmine, Physostigmine (product), Physostigmine (substance), PHYSOSTIGMINE PREPARATION, Pyrrolo(2 3 b)indol 5 ol 1 2 3 3a 8 8a hexahydro 1 3a 8 trimethyl methylcarbamate (ester) (3aS cis), Brand name/Antilirium (Physostigmine), Brand name/Eserine (Physostigmine)
- Treatment
- Drug Dosage
- DRUG/Injectable medication (parenteral)
- DRUG/Injectable preparation only
- Definition
-
ACH Inhibitor drug; Anticholinesterase inhibitor used in
drug toxicity anticholinergics/atropine/TCA and topically for glaucoma; oral and parenteral and topical ophthalmic preparations (miotic) drug; ActylCholine esterase inhibitors can cause cholinergic crisis; short half life precludes myasthenia treatment
(Edit)
- External Links Related to Physostigmine (Eserine/Antlirium) Administration/Toxicity
- Wikipedia
- Merck
- Images
- PubMed (National Library of Medicine)
- NGC (National Guideline Clearinghouse)
- Medscape (eMedicine)
- Harrison's Online (accessmedicine)
- NEJM (The New England Journal of Medicine)
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