Disease Information for Physostigmine (Eserine/Antlirium) Administration/Toxicity

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Clinical Manifestations
Signs & Symptoms
Dizzy on Standing/Giddy Response
Low Blood Pressure
Orthostatic drop in blood pressure
Regional pallor/vasospasm
Slow pulse/Bradycardia
Vasospasm of extremities/Signs
Diaphoresis profuse/active sweating/acute
Hyperhidrosis/Chronic sweating excess
Sweating Excess Perspiration
Abdominal Pain
Active Bowel Sounds
Borborygmi/Bowel sound increased
Colicky Abdominal Pain
Diarrhea
Diarrhea, explosive
Diarrhea, fulminant
Loss of bowel control/incontinence acute
Nausea
Vomiting
Seizures
Bronchospasm signs
Wheezing
Cholinergic symptoms/signs
Infrequent blinking/Stellwag sign
Lacrimation/excess tearing
Miosis/narrow pupils
Tearing
Typical Clinical Presentation
Coma with cholinergic ( SLUD) signs
Laboratory Tests
Abnormal Lab Findings - Increased
Acetyl choline level (Lab)
Diagnostic Test Results
EKG (ECG)
EKG/Widened QRS pattern (ECG)
EKG/AV Nodal Block/Complete
EKG/Sinus bradycardia (ECG)
EKG/Sinus pause (ECG)
EKG/Changes/abnormalities (ECG)
Associated Diseases & Rule outs
Associated Disease & Complications
Asthma
Brady-arrhythmia
Bradyarrhythmias
Cardiac conduction defects
Cholinergic crisis/toxidrome
Convulsions (grand mal)
Heart block, complete
Hypotension
Orthostatic syncope Hypotension
Sinus bradycardia
Disease Mechanism & Classification
Drugs
DRUG/Acetylcholinesterase inhibitor
DRUG/Antidote/specific medication (example)
DRUG/Anti-Myasthenia Gravis medication (ex)
DRUG/Cholinergic agonist drug/effect (example)
DRUG/Important Acute care drugs (example)
DRUG/Parasympatheticomemitic effect (ex)
DRUG/Lowers seizure threshold
Pathophysiology
Pathophysiology/Acetyl choline accumulation
Pathophysiology/Peristalsis increased
Pathophysiology/Neuromuscular irritability
Pathophysiology/Bronchospasm
Process
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
Toxin
TOXIN/Decreases Heart Rate
TOXIN/SLUD response(sial/lacr/urine/dia)
Synonyms
Synonym
physostigmine, Physostigmine (product), Physostigmine (substance), PHYSOSTIGMINE PREPARATION, Pyrrolo(2 3 b)indol 5 ol 1 2 3 3a 8 8a hexahydro 1 3a 8 trimethyl methylcarbamate (ester) (3aS cis), Brand name/Antilirium (Physostigmine), Brand name/Eserine (Physostigmine)
Treatment
Drug Dosage
DRUG/Injectable medication (parenteral)
DRUG/Injectable preparation only
Definition

ACH Inhibitor drug; Anticholinesterase inhibitor used in

drug toxicity anticholinergics/atropine/TCA and topically for glaucoma; oral and parenteral and topical ophthalmic preparations (miotic) drug; ActylCholine esterase inhibitors can cause cholinergic crisis; short half life precludes myasthenia treatment

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External Links Related to Physostigmine (Eserine/Antlirium) Administration/Toxicity
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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