Disease Information for Phenylephrine (Neo-synephrine) Administration/Toxicity

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Clinical Manifestations
Signs & Symptoms
Brief Blood pressure increase/sign:
Decreased peripheral pulses
High blood pressure/sign
Regional pallor/vasospasm
Systolic hypertension/diastolic normal
Vasospasm of extremities/Signs
Clinical Presentation & Variations
Presentation/Angina worse
Associated Diseases & Rule outs
Associated Disease & Complications
Alpha-Adrenergic toxidrome/syndrome
Angina, unstable/crescendo/intermediate syndrome
Arterial Occlusion
Cardiac arrhythmias
Cerebral hemorrhage
Cerebral vascular accident
Coronary ischemia
Drug induced Arrhythmias
Drug induced Pressor/acute hypertension
Drug induced Stroke/Cerebral ischemia/Bleed
Hypertension
Hypertensive crisis/Accelerated hypertension
Ischemia, cardiac
Monoamine oxidase inhibitor toxicity/crisis
Myocardial infarction, acute
Sinus bradycardia
Disease Mechanism & Classification
Drugs
DRUG/Alpha-adrenergic agonist/effect
DRUG/Important Acute care drugs (example)
DRUG/Mydriatic agent/effect
DRUG/Narrow range of safety (effect/toxic)
DRUG/Pressor (antishock) medication (ex)
Pathophysiology
Pathophysiology/Arterial Occlusion
Pathophysiology/Myocardial Ischemia Non-Arteriosclerosis
Process
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
Toxin
TOXIN/ Hypertension/slow heart rate
Synonyms
Synonym
(R) 3 Hydroxy alpha ((methylamino)methyl)benzenemethanol, Benzenemethanol 3 hydroxy alpha ((methylamino)methyl) (R), phenylephrine, Phenylephrine (product), Phenylephrine (substance), PHENYLEPHRINE PREPARATION, Brand name/Entex (Glyceryl guaiacolate-Phenylephrine), Brand name/Neo-synephrine (Phenylephrine), Brand name/Neo-synephrine (Phenylephrine) ophthalmic
Treatment
Drug Dosage
DRUG/Dose gtts/drops solution
DRUG/Dose Infusion mix 10 mgm/250 ml (CONFIRM this)
DRUG/Dose iv 40-60 mcg/min
DRUG/Dose iv soln 20mgm/250 ml d5w (80 mcg/ml)
DRUG/Generic available
DRUG/Infusion option medication
DRUG/Intranasal administration RX
DRUG/Intravenous administraton RX
DRUG/Loading dose used medication (ex)
DRUG/Ophthalmologic/application medication (ex)
Definition

Pressor drug alpha adrenergic agonist more than beta; used in ICU situations (shock); parenteral preparation; also as nasal spray decongestant

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External Links Related to Phenylephrine (Neo-synephrine) Administration/Toxicity
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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