Disease Information for Phenylbutazone (Butazolidin/Azlid) adm

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Clinical Manifestations
Signs & Symptoms
Rash
Parotid swelling
Salivary Gland Enlargement
Seizures
Laboratory Tests
Microbiology & Serology Findings
Stool Microscopic polys present
Abnormal Lab Findings - Decreased
FTI/Free Thyroxin Index (Lab)
Neutrophiles (Lab)
Platelet count (Lab)
Abnormal Lab Findings - Increased
WBC
Isocitric dehydrogenase (Lab)
pH, arterial blood (Lab)
PT -Prothrombin time (Lab)
WBC/White Blood Cell Count/Leukocytes (Lab)
Diagnostic Test Results
Pathology
BX/Liver biopsy/Granulomas in liver
Isotope Scan
Isotope/RAI uptake/quantitative high thyroid (I 123)
Associated Diseases & Rule outs
Associated Disease & Complications
Acute leukemia
Agranulocytosis
Alkalosis
Anemia, aplastic
Convulsions (grand mal)
Dermatitis/Chronic rash
Drug induced Anemia.
Drug induced GI Blood Loss
Drug induced Myelosuppression.
Drug induced Nephritis/Nephropathy
Drug induced Neutropenia.
Drug induced Rash/eruption/herbal
Drug rash/Drug induced rash
Erythema multiforme
Granulocytopenia/Neutropenia
Granulomatous liver/hepatitis syndrome
Hypersensitivity angiitis
Hypothyroidism (myxedema)
Leukemia
Myocarditis, hypersensitivity/allergy
Nephritis, interstitial
Nephritis, non-allergic interstitial
Nephritis, secondary
Red cell aplasia/marrow failure
Toxic amblyopia syndrome
Toxic epidermal necrolysis
Toxic erythema
Toxic nephritis/Chronic persistent
Toxic Nephritis/Nephropathy
Disease Synergy - Causes
Synergy/Congestive heart failure
Disease Mechanism & Classification
Drugs
DRUG/Antiphlogistic/NSAIDS drug (category)
DRUG/Antiplatelet/effect medication (example)
DRUG/Antipyetic/fever medication (ex)
DRUG/Non-steroidal anti-inflammatory drug (example)
DRUG/Oral contraceptive effect weakened
DRUG/Lowers seizure threshold
Pathophysiology
Pathophysiology/Defective thyroid hormone biosynthesis
Pathophysiology/Granulomatous liver disease
Process
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
Synonyms
Synonym
3 5 Pyrazolidinedione 4 butyl 1 2 diphenyl, Diphenylbutazone, Phenylbutazone, Phenylbutazone (product), Phenylbutazone (substance), PHENYLBUTAZONE PREPARATION, Phenylbutazone product, Phenylbutazone product (product), Phenylbutazone product (substance), Brand name/Azolid (Phenylbutazone), Brand name/Butazolidin (Phenylbutazone)
Treatment
Drug Therapy - Contraindication
RX/Warfarin (Coumadin)
Drug Dosage
DRUG/Dose p.c. (after meals/with meals)
DRUG/Drug discontinued/TOXIC (RX)
Definition

Older drug with Non-Steroidal Anti-Inflammatory activity. More COX1 than COX2 activity. Oral drug. Little used as may cause bone marrow failure and peptic ulcer.

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External Links Related to Phenylbutazone (Butazolidin/Azlid) adm
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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