Disease Information for Perphenazine (Trilafon) Administration/Toxicity

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Clinical Manifestations
Signs & Symptoms
Dizzy on Standing/Giddy Response
Orthostatic drop in blood pressure
Tachycardia/Fast heart rate
Dry mouth/Mucous membranes
Motor restlessness
Akathisia
Athetosis
Choreoathetoid movement
Dystonia, acquired
Odd body posturing
Seizures
Stupor/poor reponse to stimulus
Tremor
Unable to sit still/restlessness
Laboratory Tests
Abnormal Lab Findings - Decreased
Neutrophiles (Lab)
Abnormal Lab Findings - Increased
FTI/Free Thyroxin Index (Lab)
Thyroxin/T4 (Lab)
Diagnostic Test Results
Isotope Scan
Isotope/RAI uptake/quantitative high thyroid (I 123)
EKG (ECG)
EKG/Widened QRS pattern (ECG)
EKG/Changes/abnormalities (ECG)
X-RAY
Xray/Radiopaque material/pills in gut/ABD
Associated Diseases & Rule outs
Associated Disease & Complications
Cardiac arrhythmias
Convulsions (grand mal)
Drug induced Acute dystonia reaction
Drug Induced Choreoathetosis
Drug induced Movement disorder
Drug induced Orthostatic hypotension
Neuroleptic malignant syndrome
Orthostatic hypotension syndrome
Orthostatic syncope Hypotension
Parkinsonism, secondary
Sedation/torpor induced
Tardive dyskinesia syndrome
Urinary bladder retention
Disease Mechanism & Classification
Drugs
DRUG/Antiemetic medication (examples)
DRUG/Antipsychotic/neuroleptic drug (example)
DRUG/Anti-Schizophrenia medication (example)
DRUG/Dopamine antagonist (example)
DRUG/Phenothiazine class drug (example)
DRUG/Psychoactive/sedative drug (category)
DRUG/Lowers seizure threshold
Process
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
Synonyms
Synonym
1 Piperazineethanol 4 (3 (2 chloro 10H phenothiazin 10 yl)propyl), 4 (3 (2 Chloro 10H phenothiazin 10 yl)propyl) 1 piperazineethanol, Chlorpiprazine, Perfenazine, Perphenazine, Perphenazine (anaesthesia), Perphenazine (anesthesia), Perphenazine (anesthesia) (product), Perphenazine (anesthesia) (substance), Perphenazine (central nervous system use), Perphenazine (central nervous system use) (product), Perphenazine (central nervous system use) (substance), Perphenazine (CNS), Perphenazine (product), Perphenazine (substance), PERPHENAZINE PREPARATION, Brand name/Etrafon (Perphenazine-Amitriptyline), Brand name/Trilafon (Perphenazine)
Treatment
Drug Dosage
DRUG/Dose 16 mgms (Unit/Pill/Capsule size)
DRUG/Dose 2 mgm (Unit/Pill/Capsule size)
DRUG/Dose 4 mgm (Unit/Pill/Capsule size)
DRUG/Dose 8 mgms (Unit/Pill/Capsule size)
DRUG/Injectable medication (parenteral)
DRUG/Intramuscular injection RX
DRUG/Oral medication (ex)
Definition

Thorazine-like drug; class of neuroleptic drugs for anti-psychosis effect; oral and parenteral preparation; causes sedation, tardive dyskinesia; basal ganglia effects; wide margin of safety

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External Links Related to Perphenazine (Trilafon) Administration/Toxicity
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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