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Disease Information for Perphenazine (Trilafon) Administration/Toxicity

Clinical Manifestations

Signs & Symptoms

Dizzy on Standing/Giddy Response

Orthostatic drop in blood pressure

Tachycardia/Fast heart rate

Dry mouth/Mucous membranes

Motor restlessness

Akathisia

Athetosis

Choreoathetoid movement

Dystonia, acquired

Odd body posturing

Seizures

Stupor/poor reponse to stimulus

Tremor

Unable to sit still/restlessness

Laboratory Tests

Abnormal Lab Findings - Decreased

Neutrophiles (Lab)

Abnormal Lab Findings - Increased

FTI/Free Thyroxin Index (Lab)

Thyroxin/T4 (Lab)

Diagnostic Test Results

Isotope Scan

Isotope/RAI uptake/quantitative high thyroid (I 123)

EKG (ECG)

EKG/Widened QRS pattern (ECG)

EKG/Changes/abnormalities (ECG)

X-RAY

Xray/Radiopaque material/pills in gut/ABD

Associated Diseases & Rule outs

Associated Disease & Complications

Cardiac arrhythmias

Convulsions (grand mal)

Drug induced Acute dystonia reaction

Drug Induced Choreoathetosis

Drug induced Movement disorder

Drug induced Orthostatic hypotension

Neuroleptic malignant syndrome

Orthostatic hypotension syndrome

Orthostatic syncope Hypotension

Parkinsonism, secondary

Sedation/torpor induced

Tardive dyskinesia syndrome

Urinary bladder retention

Disease Mechanism & Classification

Drugs

DRUG/Antiemetic medication (examples)

DRUG/Antipsychotic/neuroleptic drug (example)

DRUG/Anti-Schizophrenia medication (example)

DRUG/Dopamine antagonist (example)

DRUG/Phenothiazine class drug (example)

DRUG/Psychoactive/sedative drug (category)

DRUG/Lowers seizure threshold

Process

PROCESS/Medication/Drug (CONFIRM dose/before treatment)

Synonyms

Synonym

1 Piperazineethanol 4 (3 (2 chloro 10H phenothiazin 10 yl)propyl), 4 (3 (2 Chloro 10H phenothiazin 10 yl)propyl) 1 piperazineethanol, Chlorpiprazine, Perfenazine, Perphenazine, Perphenazine (anaesthesia), Perphenazine (anesthesia), Perphenazine (anesthesia) (product), Perphenazine (anesthesia) (substance), Perphenazine (central nervous system use), Perphenazine (central nervous system use) (product), Perphenazine (central nervous system use) (substance), Perphenazine (CNS), Perphenazine (product), Perphenazine (substance), PERPHENAZINE PREPARATION, Brand name/Etrafon (Perphenazine-Amitriptyline), Brand name/Trilafon (Perphenazine)

Treatment

Drug Dosage

DRUG/Dose 16 mgms (Unit/Pill/Capsule size)

DRUG/Dose 2 mgm (Unit/Pill/Capsule size)

DRUG/Dose 4 mgm (Unit/Pill/Capsule size)

DRUG/Dose 8 mgms (Unit/Pill/Capsule size)

DRUG/Injectable medication (parenteral)

DRUG/Intramuscular injection RX

DRUG/Oral medication (ex)

Definition

Thorazine-like drug; class of neuroleptic drugs for anti-psychosis effect; oral and parenteral preparation; causes sedation, tardive dyskinesia; basal ganglia effects; wide margin of safety

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External Links Related to Perphenazine (Trilafon) Administration/Toxicity

PubMed (National Library of Medicine)

NGC (National Guideline Clearinghouse)

Medscape (eMedicine)

Harrison's Online (accessmedicine)

NEJM (The New England Journal of Medicine)

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