Disease Information for Peroneal muscular atrophy(Charcot Mar.)

Peroneal muscular atrophy is a hereditary motor and sensory neuropatrhy; usual onset with progressive distal lower extremity wasting with classic steppage gait from bilateral foot drop; sensory changes occur and motor neuropathy eventually invoves the hands and arms; onset in puberty -------------------------------------------------------------

Charcot-Marie-Tooth disease; Charcot-Marie syndrome;

Charcot-Marie-Tooth-Hoffmann disease; Charcot-Marie-Tooth-Hoffmann syndrome; Tooth muscular atrophy; Tooth’s syndrome;

Atrophia musculorum progressiva neurotica sive neuralis; hereditary motor and sensory neuropathy I (HMSN I); neuropathic muscular atrophy, peroneal muscle atrophy;

A syndrome characterized by slowly progressive wasting and weakness of distal muscle of the arms and feet, caused by degeneration of the peripheral nerves, nerve roots, and even the spinal cord, with loss of reflexes, loss of cutaneous sensations and develeopment of foot drop; Optic atrophy is sometimes present; Usually develops in childhood or adolescence and progresses slowly, but may occur in adults; more common in males than in females; Its cause is unknown; The affected child has normal intelligence, and a normal life span; It is transmitted as an autosomal dominant or recessive trait in some families and as X-linked trait in others; Relatively rare syndrome;

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