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- Disease Information
- Disease Comparison
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Disease Processes ▼
- Auto Immune
- Vascular-Arteriosclerosis
- Biochemical
- Congenital-developmental
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Major Organs-Systems ▼
- Systemic
- Pediatric
- Nervous & Sensory System (Neurology)
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- Respiratory (Pulmonary) System
- Gastro-Intestinal (Digestive) System
- Urinary System
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- Endocrine System
- Immune System
- Musculoskeletal System
- Genital Reproductive System
- Hematopoietic System (Hematology)
- Lymphatic System
- Tissue/Cells/Organelles
Disease Information for Periodic paralysis
- Clinical Manifestations
- Signs & Symptoms
- Acute Motor Weakness
- Episodic muscle weakness
- Muscle Pain
- Muscle tone/decreased
- Muscle weakness
- Myalgias
- Symmetrical muscle/pain, weakness
- Tender or painful muscles/Myalgias
- Weak/Weak as a kitten (symptom)
- Abdominal reflex decreased
- Absent deep tendon reflexes
- Absent knee reflexes
- Fatigability
- Flaccid muscle paralysis
- Intermittant flaccid paralysis
- Monoplegia, arm
- Monoplegia, leg
- Paralysis
- Transient limb paralysis/palsy
- Weakness/Diffuse motor loss
- Shallow breathing
- Acutely ill patient/signs
- Enervated/extreme acute fatigue
- Episodic symptoms/events
- Fatigue
- Fatigue Prolonged after Exercise
- Fatigue Tiredness Exhaustion
- Spells/Episodes of weakness
- Weakness
- Weakness non-neuromuscular/systemic
- Disease Progression
- Course/Acute
- Course/Attacks Episodic Spells
- Course/Attacks last 1 to 2 days
- Course/Chronic disease crisis/flare/attacks
- Course/Chronic disorder
- Course/Paroxysmal
- Course/Periodic Episodic
- Course/Recurrent illness pattern
- Course/slow resolution of attack/hours
- Demographics & Risk Factors
- Population Group
- Child
- Population/Pediatrics population
- Event, Activity, Behavioral & Seasonal Factors
- Activity/Jogging/running
- Sex & Age Groups
- Population/Child
- Population/Children/all
- Laboratory Tests
- Abnormal Lab Findings - Decreased
- Lactic acid/Lactate (Lab)
- Abnormal Lab Findings - Increased
- Potassium, serum (Lab)
- Associated Diseases & Rule outs
- Rule Outs
- Cataplexy
- Guillain-Barre syndrome
- Muscular dystrophy
- Associated Disease & Complications
- Acute respiratory failure/Respiratory arrest
- Biochemical myopathy
- Hyperkalemia
- Hypokalemia
- Periodic paralysis syndrome
- Respiratory muscle paralysis
- Respiratory muscle weakness
- General paralysis/General Paresis
- Disease Synergy - Causes
- Synergy/Carbohydrate excess/diet
- Synergy/Cold environment
- Synergy/Exercise/severe
- Synergy/Overeating/episode
- Synergy/Rest/after vigorous exercise
- Disease Mechanism & Classification
- Class
- CLASS/Muscle disorder (ex)
- CLASS/Muscle/tendon/extremities (category)
- CLASS/Striated muscle disorder (ex)
- Pathophysiology
- Pathophysiology/Genomic indentifiers (polymorphism/snip/mutations)
- Pathophysiology/Metabolic myopathy (ex)
- Pathophysiology/Lung Ventilation Neuromuscular
- Process
- PROCESS/Autosomal dominant hereditary disease (ex).
- PROCESS/Biochemical (category)
- PROCESS/Episodic disorder (ex)
- PROCESS/Ethnic predilection (ex)
- PROCESS/Hereditofamilial (category)
- PROCESS/Metabolic/storage disorder (category)
- Treatment
- Drug Therapy - Indication
- RX/Acetazolamide (Diamox)
- RX/Potassium
- Other Treatments
- TX/Genetic counselling
- Definition
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A heterogenous group of inherited disorders characterized by recurring attacks of rapidly progressive flaccid paralysis or myotonia. These conditions have in common a mutation of the gene encoding the alpha subunit of the sodium channel in skeletal muscle. They are frequently associated with fluctuations in serum potassium levels. Periodic paralysis may also occur as a non-familial process secondary to THYROTOXICOSIS and other conditions. (From Adams et al., Principles of Neurology, 6th ed, p1481)
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- External Links Related to Periodic paralysis
- Wikipedia
- Merck
- Images
- PubMed (National Library of Medicine)
- NGC (National Guideline Clearinghouse)
- Medscape (eMedicine)
- Harrison's Online (accessmedicine)
- NEJM (The New England Journal of Medicine)
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