Disease Information for Periodic paralysis

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Clinical Manifestations
Signs & Symptoms
Acute Motor Weakness
Episodic muscle weakness
Muscle Pain
Muscle tone/decreased
Muscle weakness
Myalgias
Symmetrical muscle/pain, weakness
Tender or painful muscles/Myalgias
Weak/Weak as a kitten (symptom)
Abdominal reflex decreased
Absent deep tendon reflexes
Absent knee reflexes
Fatigability
Flaccid muscle paralysis
Intermittant flaccid paralysis
Monoplegia, arm
Monoplegia, leg
Paralysis
Transient limb paralysis/palsy
Weakness/Diffuse motor loss
Shallow breathing
Acutely ill patient/signs
Enervated/extreme acute fatigue
Episodic symptoms/events
Fatigue
Fatigue Prolonged after Exercise
Fatigue Tiredness Exhaustion
Spells/Episodes of weakness
Weakness
Weakness non-neuromuscular/systemic
Disease Progression
Course/Acute
Course/Attacks Episodic Spells
Course/Attacks last 1 to 2 days
Course/Chronic disease crisis/flare/attacks
Course/Chronic disorder
Course/Paroxysmal
Course/Periodic Episodic
Course/Recurrent illness pattern
Course/slow resolution of attack/hours
Demographics & Risk Factors
Population Group
Child
Population/Pediatrics population
Event, Activity, Behavioral & Seasonal Factors
Activity/Jogging/running
Sex & Age Groups
Population/Child
Population/Children/all
Laboratory Tests
Abnormal Lab Findings - Decreased
Lactic acid/Lactate (Lab)
Abnormal Lab Findings - Increased
Potassium, serum (Lab)
Associated Diseases & Rule outs
Rule Outs
Cataplexy
Guillain-Barre syndrome
Muscular dystrophy
Associated Disease & Complications
Acute respiratory failure/Respiratory arrest
Biochemical myopathy
Hyperkalemia
Hypokalemia
Periodic paralysis syndrome
Respiratory muscle paralysis
Respiratory muscle weakness
General paralysis/General Paresis
Disease Synergy - Causes
Synergy/Carbohydrate excess/diet
Synergy/Cold environment
Synergy/Exercise/severe
Synergy/Overeating/episode
Synergy/Rest/after vigorous exercise
Disease Mechanism & Classification
Class
CLASS/Muscle disorder (ex)
CLASS/Muscle/tendon/extremities (category)
CLASS/Striated muscle disorder (ex)
Pathophysiology
Pathophysiology/Genomic indentifiers (polymorphism/snip/mutations)
Pathophysiology/Metabolic myopathy (ex)
Pathophysiology/Lung Ventilation Neuromuscular
Process
PROCESS/Autosomal dominant hereditary disease (ex).
PROCESS/Biochemical (category)
PROCESS/Episodic disorder (ex)
PROCESS/Ethnic predilection (ex)
PROCESS/Hereditofamilial (category)
PROCESS/Metabolic/storage disorder (category)
Treatment
Drug Therapy - Indication
RX/Acetazolamide (Diamox)
RX/Potassium
Other Treatments
TX/Genetic counselling
Definition

A heterogenous group of inherited disorders characterized by recurring attacks of rapidly progressive flaccid paralysis or myotonia. These conditions have in common a mutation of the gene encoding the alpha subunit of the sodium channel in skeletal muscle. They are frequently associated with fluctuations in serum potassium levels. Periodic paralysis may also occur as a non-familial process secondary to THYROTOXICOSIS and other conditions. (From Adams et al., Principles of Neurology, 6th ed, p1481)

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External Links Related to Periodic paralysis
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PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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