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Disease Processes ▼
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Disease Information for Paraneoplastic multifocal encephalomyelitis
- Clinical Manifestations
- Signs & Symptoms
- Abnormal movements/involuntary
- Ataxia
- Confusion/Disoriented
- Conjugate gaze paralysis
- Cranial nerve abnormalities/involvement/signs
- Dysarthria
- Dysconjugate gaze
- Irritability/short tempered
- Multifocal neurologic deficit/signs
- Nystagmus
- Staggering Gait
- Temporal lobe signs
- Difficulty Talking
- Opsoclonus/chaotic eye movements
- True Vertigo Sign Confirmed
- Disease Progression
- Course/2 to 3 months
- Course/Acute on subacute
- Course/Progressive
- Course/Subacute
- Laboratory Tests
- Abnormal Lab Findings (Non Measured)
- Anti-Neuron [ANNA ] Paraneoplastic antigens (1,2,2a) abnormalities
- Paraneoplastic Antibody Panel (Lab)
- Abnormal Lab Findings - Increased
- Anti-GAD antibodies
- Anti-Glutamic Acid decarboxylase antibodies/GAD
- Anti-Hu/ANNA-IIA Paraneoplastic antigen (Lab)
- Anti-Ma/Neuronal antibodies (Lab)
- Anti-Purkinje/APCA/Anti-yo titer (Lab)
- Anti-Ri/ANNA-2 paraneoplastic antigen (Lab)
- CSF Anti-Hu (ANNA 2a) antibodies
- CSF Cells
- Diagnostic Test Results
- Other Tests & Procedures
- Lumbar puncture/Increased CSF pressure/LP test
- Pathology
- PATH/Brain focal encephalopathy
- CT Scan
- MRI/Head Brain FLAIR Image Abnormal
- MRI/Head Gadolium contrast abnormal
- MRI/Head T2 and fluid -attenuated inversion recovery
- Associated Diseases & Rule outs
- Rule Outs
- Alzheimers disease
- Associated Disease & Complications
- Coma/Unconscious
- Cranial nerve palsy
- Dorsal root sensory neuropathy/paraneoplastic
- Paraneoplastic multifocal encephalomyelitis
- Progressive Supranuclear Palsy
- Ataxia Disorder
- Disease Mechanism & Classification
- Class
- CLASS/Neurologic (category)
- Pathophysiology
- Pathophysiology/CNS degeneration
- Process
- PROCESS/Autoimmune disorder (ex)
- PROCESS/Neoplastic (category)
- PROCESS/Paraneoplastic disorder (ex)
- PROCESS/Paraneoplastic neurologic disorder
- Synonyms
- Synonym
- Encephalomyelitis Paraneoplastic, PARANEOPL ENCEPH, Paraneoplastic Encephalomyelitides, Paraneoplastic encephalomyelitis, Paraneoplastic encephalomyelitis (disorder), Synonym/Paraneoplastic encephalomyelitis/Myelitis variant, Synonym/Paraneoplastic cortical encephalitis variant, Synonym/Paraneoplastic encephalitis/brainstem variant
- Treatment
- Drug Therapy - Indication
- RX/Gamma globulin (intravenous, high dose)
- RX/High dose Steroid trial [six weeks]
- RX/Immunoglobulin infusion
- Other Treatments
- TX/Plasmapheresis/exchange.
- Definition
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Parneoplastic multifocal encephalomyelitis includes subsets of brain stem, limbic basal ganglia, cortical encephalitis, and overlaps with cerebella, myelitis, and autonomic syndromes. autoimmune disorder opoften precedes tumor and that tumor often small cell lung cancer; limbic encephalitis is the only one that responds well to treatment IVIG/Steroids/RX tumor/Immun suppression
(Edit)
- External Links Related to Paraneoplastic multifocal encephalomyelitis
- Wikipedia
- Merck
- Images
- PubMed (National Library of Medicine)
- NGC (National Guideline Clearinghouse)
- Medscape (eMedicine)
- Harrison's Online (accessmedicine)
- NEJM (The New England Journal of Medicine)
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