Disease Information for Panniculitis, nodular nonsuppurative

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Clinical Manifestations
Signs & Symptoms
Painful fat pads
Painful subcutaneous nodules
Skin nodules/Subcutaneous nodules
Subcutaneous nodules
Subcutaneous/mass
Subcutaneous/painful/red nodules/shins
Abdominal Pain
Chronic Abdominal Pain
Recurrent Abdominal Pain
Anterior leg pain
Muscle Pain
Myalgias
Tender or painful muscles/Myalgias
Anterior thigh pain
Cyclic Periodic Recurrent Fevers
Episodic symptoms/events
Fever
Fever episodes/3-5 days/relapse
Fever Febrile Possible
Fever, intermittant/recurrent
Flu-Like Syndrome
High body temperature
Malaise
Periodic fever
Clinical Presentation & Variations
Presentation/Painful Nodules Legs Feet Recurrent Adult healthy
Disease Progression
Course/Chronic disorder
Course/Chronic only
Course/Episodes last 1 to 3 weeks/remit recur months later
Course/Episodic clusters of attacks
Course/No sequelae expected
Course/Recurrent illness pattern
Course/Remittant/spontaneous
Laboratory Tests
Abnormal Lab Findings (Non Measured)
Acute inflammatory markers elevated (Lab)
Abnormal Lab Findings - Decreased
Alpha-1-antitrypsin globulin level (Lab)
Diagnostic Test Results
Pathology
BX/Abdominal Fat-Pad tissue biopsy/abnormal
BX/Adipose tissue biopsy/abnormal
BX/Liver biopsy/Fatty change in liver tissue
PATH/Granulomatous tissue/specimen
X-RAY
Xray/Calcifications Subcutaneous
Xray/Subcutaneous ossification centers/calcification
Xray/Calcifications of soft tissue, multiple
Xray/Muscle calcification
Xray/Soft tissue calcification/muscle/subcutaneous
X-RAY With contrast
SBS/Mucosal folds thickened, intestinal (Xray)
SBS/Valvulae conniventes thickened (Xray)
Associated Diseases & Rule outs
Rule Outs
Erythema nodosum
Non-alcoholic fatty liver disease
Associated Disease & Complications
Fatty liver
Panniculitis
Panniculitis nonsuppurative nodular/relapsing
Steatohepatitis
Leg ulcers
Disease Mechanism & Classification
Class
CLASS/Primary organ/system disorder (ex)
CLASS/Soft Tissue Involvement
CLASS/Vascular Small Vessel Disorder
CLASS/Dermatologic/Subcutaneous (category)
CLASS/Fatty tissue/subcutaneous disorder (ex)
CLASS/Subcutaneous/Panniculus tissue disorder
CLASS/Lower extremity involvement/disorder (ex)
Pathophysiology
Pathophysiology/Hypersensitivity Vasculitis
Pathophysiology/Small Vessel Vasculitis
Pathophysiology/Subcutaneous manifestation/involvement
Process
PROCESS/Allergy/collagen/autoimmune (category)
PROCESS/Autoimmune disorder (ex)
PROCESS/Episodic disorder (ex)
PROCESS/Idiopathic/unclassified/unknown (category)
PROCESS/INCIDENCE/Rare disease (ex)
PROCESS/Inflammatory/Allergy/immune (ex)
PROCESS/Inflammatory/Granulomatous disease (ex)
PROCESS/Paraneoplastic disorder (ex)
PROCESS/Granulomatous Disease
Synonyms
Synonym
Christian Weber, Disease Weber Christian, Nod non supp febr panniculitis, Nodular non suppurative febrile panniculitis, Nodular Nonsuppurative Panniculitides, Nodular Nonsuppurative Panniculitis, Nonsuppurative Panniculitides Nodular, Nonsuppurative Panniculitis Nodular, Panniculitides Nodular Nonsuppurative, Panniculitis Nodular Nonsuppurative, Panniculitis non suppurative relapsing nodular, PFEIFFER WEBER CHRISTIAN SYNDROME, Relapsing febrile nodular nonsuppurative panniculitis, Relapsing febrile nodular nonsuppurative panniculitis (disorder), Relapsing panniculitis, Relapsing panniculitis (Weber Christian), Systemic nodular panniculitis, Weber Christian disease, Weber Christian, WEBER CHRISTIAN DIS, Weber Christian Disease, Weber Christian panniculitis, Weber Kindler syndrome, Synonym/Panniculitis, idiopathic nodular, Synonym/Pfeiffer-Weber-Christian syndrome, Synonym/Relapsing febrile nodular nonsuppurative panniculitis, Synonym/Weber-Christian disease
Definition

A form of panniculitis characterized by recurrent episodes of fever accompanied by the eruption of single or multiple erythematous subcutaneous nodules on the lower extremities. They normally resolve, but tend to leave depressions in the skin. The condition is most often seen in women, alone or in association with other disorders.

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External Links Related to Panniculitis, nodular nonsuppurative
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PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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