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Disease Information for PANDAS/Tic Disorder

Clinical Manifestations
Signs & Symptoms: Facial tic
: Attacks, neurologic, recurrent, varied; Behavior problems; Extrapyramidal signs; Fine-motor coordination problems; Finger to nose test abnormality; Inattention; Intelligence normal; Involuntary movements; Neurologic manifestations/signs; Neurological symptoms/signs; Tics/sign; Vocal tic
: Behavior characteristic/oppositional/rigid/stubborn; Chronic/recurrent anxiety; Compulsive behavior; Destructive Behavior; Idea Fixed/Singleness of thinking; Queer bizarre behavior/change; Ritualistic behavior patterns; Separation anxiety/Child; Stubborn
: Sore throat/Pharyngitis; Sore Throat/Throat Pain; Throat Conditions
Disease Progression: Course/Paroxysmal; Course/Recurrent; Course/Self limited usually; Onset/Acute; Onset/Overnight
Demographics & Risk Factors
Established Disease Population: Patient/Phenothiazine treated
: Patient/Humoral immune defect
Population Group: Population/Previously well
Sex & Age Groups: Population/Child; Population/Old child; Population/Pre-teen
Laboratory Tests
Microbiology & Serology Findings: Microlab/Throat culture positive
: Microlab/Throat culture/beta strep culture/type A
Abnormal Lab Findings - Increased: Anti-Basal Ganglion Neuronal Antibody (Lab); Anti-Streptolysin DNAase B (Lab)
: ASOT/Anti-streptolysin-O titer (Lab)
Associated Diseases & Rule outs
Rule Outs: Chorea, Sydenham's; Gilles de Tourette syndrome
Associated Disease & Complications: Anxiety; Autoimmune disease; Extrapyramidal disease/manifestation; Habit spasm/tic; Neurobehavior Problems; Neurologic side effects; PANDAS/Tic Disorder
Disease Synergy - Causes: Synergy/Stress/Anxiety
Disease Mechanism & Classification
Class: CLASS/Basal ganglia lesion/involvement/disorders (ex); CLASS/Cerebellar disorder (ex); CLASS/Neurologic (category)
Pathophysiology: Pathophysiology/Humoral autoantibody
Process: PROCESS/Allergy/collagen/autoimmune (category); PROCESS/Autoimmune disorder (ex); PROCESS/Episodic disorder (ex); PROCESS/Hierarchic item/group of diseases (category); PROCESS/INCIDENCE/Rare disease (ex); PROCESS/Vegetative-Autonomic/Endocrine (category)
Synonyms
Synonym: 9 15 TIC DISORDERS, AUTOIMMUNE DIS NERVOUS SYSTEM, AUTOIMMUNE DIS NEUROL, Autoimmune Disease Neurologic, Autoimmune Diseases Nervous System, Autoimmune Diseases Neurologic, Autoimmune Diseases of the Nervous System, Autoimmune Disorders Nervous System, Autoimmune Disorders of the Nervous System, AUTOIMMUNE NERVOUS SYSTEM DIS, Autoimmune Nervous System Diseases, autoimmune nervous system disorder, Disease Neurologic Autoimmune, Diseases Neurologic Autoimmune, Group A streptococcus, Micrococcus scarlatinae, NERVOUS SYSTEM AUTOIMMUNE DIS, Nervous System Autoimmune Diseases, NEUROL AUTOIMMUNE DIS, Neurologic Autoimmune Disease, Neurologic Autoimmune Diseases, S pyogenes, spasm tic, STREP GROUP A, STREP PYOGENES, Streptococc Lancefield group A, Streptococcus erysipelatos, streptococcus group A, Streptococcus hemolyticus, Streptococcus Lancefield group A, Streptococcus Lancefield group A (organism), Streptococcus pyogenes, Streptococcus pyogenes (organism), Streptococcus pyogenes Rosenbach 1884, Streptococcus scarlatinae, tic, Tic (dup) (finding), Tic (finding), TIC DIS, Tic disorder, Tic disorder (disorder), Tic disorder unspecified, Tic disorder unspecified (finding), Tic disorders, Tic disorders (finding), tic spasm, Tics, Synonym/Pediatric Autoimmune Neuropsychiatric Disorder Associated Streptococcus, Synonym/Post-streptococcal Autoimmune Neurologic Pediatric Immune Disorder
Treatment
Drug Therapy - Indication: RX/Antibiotic; RX/Gamma globulin (intravenous, high dose); RX/Penicillin; RX/Valproic/divalproex (Depakote/Epival)
Other Treatments: TX/Plasmapheresis/exchange.
Definition: Be the first to add a definition for PANDAS/Tic Disorder
External Links Related to PANDAS/Tic Disorder: Google; Wikipedia; Merck; Images; PubMed (National Library of Medicine); NGC (National Guideline Clearinghouse); Medscape (eMedicine); Harrison's Online (accessmedicine); NEJM (The New England Journal of Medicine)

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