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Disease Information for Paclitaxel (Taxol) Administration/Toxicity

Clinical Manifestations

Signs & Symptoms

Baldness/Alopecia

Hair loss

Non-scarring Alopecia/balding

Arthralgias Polyarthralgias

Joint Pains

Laboratory Tests

Abnormal Lab Findings - Increased

Platelet count (Lab)

Associated Diseases & Rule outs

Associated Disease & Complications

Agranulocytosis

Bone marrow failure/exhaustion

Drug induced Arthritis Arthralgias

Drug induced Baldness/Alopecia

Drug induced Hair loss

Drug induced Myelosuppression.

Drug induced Neutropenia.

Drug induced Peripheral neuropathy.

Granulocytopenia/Neutropenia

Myelosuppression

Peripheral neuropathy

Polyarthritis syndrome/Multiple joints/weeks

Disease Mechanism & Classification

Drugs

DRUG/Antimitotics Chemotherapy

DRUG/Anti-neoplastic medications (examples)

DRUG/Anti-tumor plant alkaloids (example)

DRUG/Chemotherapeutics/cancer drugs/etc (category)

DRUG/Derivative Pacific Yew bark anti-cancer agent

DRUG/Microtubule effect/mitotic arrest

DRUG/Mitotic inhibitor/spindle poison (ex)

DRUG/Yew Tree Derivative/Extract

Synonyms

Synonym

(2aR (2a Alpha 4beta 4a beta 6beta 9alpha(alphaR* betaS*) 11alpha 12alpha 12a alpha 12b alpha)) beta (benzoylamino) alpha hydroxybenzene propanoic acid 6 12b bis(acetyloxy) 12 (benzoyloxy) 1a 33 4 41 5 6 9 10 11 12 12a 12b dodecahydro 4 11 dihydroxy 41, 5Beta 20 epoxy 1 2alpha 4 7beta 10beta 13alpha hexahydroxytax 11 en 9 one 4 10 Diacetate 2 Benzoate 13 Ester with (2R 3S) N Benzoyl 3 phenylisoserine, Benzenepropanoic acid beta (benzoylamino) alpha hydroxy 6 12b bis(acetyloxy) 12 (benzoyloxy) 2a 3 4 4a 5 6 9 10 11 12 12a 12b dodecahydro 4 11 dihydroxy 4a 8 13 13 tetramethyl 5 oxo 7 11 methano 1H cyclodeca(3 4)benz(1 2 b)oxet 9 yl ester (2aR (2aalph, PACLITAXEL, Paclitaxel (product), Paclitaxel (substance), PACLITAXEL PREPARATION, TAX, Brand name/Abraxane (Paclitaxel protein bound particles), Brand name/Onyx (Pacetaxol), Brand name/Onyx (Paclitaxel), Brand name/Taxol (Paclitaxel)

Treatment

Drug Dosage

DRUG/.1992 Approx/New drug

DRUG/Dose special schedule/course

DRUG/Injectable medication (parenteral)

DRUG/Injectable preparation only

DRUG/Intravenous administraton RX

DRUG/Intravenous only RX

Definition

Cancer chemotherapy drug; Antitumor alkaloid plant (yew tree) extracted and derived

(Edit)

External Links Related to Paclitaxel (Taxol) Administration/Toxicity

PubMed (National Library of Medicine)

NGC (National Guideline Clearinghouse)

Medscape (eMedicine)

Harrison's Online (accessmedicine)

NEJM (The New England Journal of Medicine)

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