Disease Information for Optica neuromyelitis/Devic disease

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Clinical Manifestations
Signs & Symptoms
Bowel/Stool Incontinence
Spastic paralysis/signs
Spastic paraplegia/signs
Urine Incontinence
Weakness
Central Vision Loss/Scotoma
Chronic Progressive Vision Loss
Chronic Vision Loss, Persistent
Eye symptoms/signs
Loss of color vision
Painless Vision Loss
Pallor/white optic disk
Vision Loss
Visual Problems
Visual symptoms
Disease Progression
Course/Chronic disorder
Course/Chronic only
Demographics & Risk Factors
Travel, Geographic & Climate Related Factors
Residence/travel/Africa
Residence/travel/Asia
Ethnic or Racial Factors
African black population
Asian population
Black/African american population
Hispanic/Latino population
Japanese population/ethnic stock
Southeast Asian/Population
Sex & Age Groups
Population/Female
Laboratory Tests
Abnormal Lab Findings - Increased
Anti-NMO IGG Antibodies
Diagnostic Test Results
Other Tests & Procedures
Visual Fields Test Abnormal
Visual Fields/Central visual field loss
Pathology
PATH/Spinal cord necrosis/lesions
PATH/Mononuclear/perivascular infiltrate
Electrodiagnosis
EEG/Evoked Potential Responses Abnormal
EEG/Visual evoked response/abnormality
CT Scan
MRI/Cord T2 Lesion 3 Vertebra length
MRI/Head Demyelination white matter
MRI/Spinal cord abnormalities
Associated Diseases & Rule outs
Rule Outs
Brain tumor
Multiple sclerosis
Optic neuritis
Primary Brain Neoplasm
Associated Disease & Complications
Anal Incontinence
Blindness
Blindness in Children
Brain stem lesion
Myelitis
Myelitis, transverse
Neuromyelitis optica
Optic neuritis
Paraplegia
Paraplegia, spastic
Quadriparesis/quadriplegia
Transverse myelitis, subacute
Visual acuity loss
Demyelinating Disease
Disease Mechanism & Classification
Class
CLASS/Neurologic (category)
CLASS/Eye involvement/disorder (ex)
CLASS/Eyes/accessory (category)
CLASS/Optic nerve/Radiation tracts/Chiasm
Pathophysiology
Pathophysiology/Humoral autoantibody
Pathophysiology/Cerebral demyelination
Pathophysiology/Demyelinating Spares Brain
Pathophysiology/Demyelination
Pathophysiology/Antibodies IGG NMO/Aquaporin 4
Process
PROCESS/Allergy/collagen/autoimmune (category)
PROCESS/Autoimmune disorder (ex)
PROCESS/Inflammatory/Allergy/immune (ex)
PROCESS/Inflammatory/infection (ex)
PROCESS/Use/Age/atrophic disorder (category)
Synonyms
Synonym
Devic, DEVIC DIS, Devic Disease, Devic syndrome, DEVICS DIS, Devics Disease, Devic's Disease, Devics Syndrome, Devic's Syndrome, Devic's Syndromes, Disease Devic, Disease Devic's, MYELITIS OPTIC NEURITIS IN, neuritis optica demyelination, Neuro optic myelitis, NEUROENCEPHALOMYELOPATHY OPTIC, neuromyelitis optic, Neuromyelitis optica, Neuromyelitis optica (Devic), Neuromyelitis optica (disorder), ophthalmoneuromyelitis, optic neuromyelitis, Syndrome Devic, Syndrome Devic's, Syndromes Devic's, Synonym/Devic's disease, Synonym/Myelitis with optic neuritis syndrome, Synonym/NMO, Synonym/Ophthalmoneuromyelitis, Synonym/Optic neuroencephalomyelopathy, Synonym/Optic neuromyelitis
Treatment
Drug Therapy - Indication
RX/Azathioprine (Imuran)
RX/Corticosteroid (Cortisone)
RX/Immune-suppression
RX/Rituximab (Retuxan)
Other Treatments
TX/Plasmapheresis/exchange.
Definition

Demyelinization of optic nerves, chiasm, and spinal cord; MRI abnormal in a different pattern than MS; Complete remission may occur [after an infection or common cold, it is considered a post-infectious acute demyelinated encephalomyelitis (ADE) rather than Devic"s syndrome]--------------------------------------------------------

Devic"s syndrome is a rare autoimmune central nervous system disorder characterized by transverse myelitis (in which the fatty, protective covering of the spinal cord breaks down) and optic neuritis (in which inflammation of the optic nerve causes loss of vision and eye pain); It is considered a special form of multiple sclerosis (MS) with a severe and rapid course; The disorder affects the optic nerve and the nerves in the spinal cord; In Devic"s syndrome, the fatty sheath that protects these nerves is lost; Individuals may experience vision impairment and various degrees of paralysis, as well as incontinence; The disorder is closely linked with MS and lupus, but usually appears before any symptoms of MS are noted; If an isolated disease episode affecting the spinal cord and optic nerve occurs after an infection or common cold, it is considered a post-infectious acute demyelinated encephalomyelitis (ADE) rather than Devic"s syndrome; There is currently no standard treatment for Devic"s syndrome; Generally, treatment is symptomatic and supportive; Corticosteroids may be prescribed; Treatment for ADE may include corticosteroids, intravenous immunoglobulin, and intravenous methylprednisolone ; Prognosis is poor: Devic"s syndrome is fatal in many patients; Some ADE patients achieve complete or nearly complete recovery while others may have residual deficits; Some severe cases of ADE may be fatal------------- [NINDS 2005]-----------------------------------

Devic Disease; Devic Syndrome;Neuromyelitis Optica;

Opthalmoneuromyelitis; Optic Neuroencephalomyelopathy;

Optic Neuromyelitis; Opticomyelitis; Retrobulbar Neuropathy;

Devic disease, also known as neuromyelitis optica, is a rare nerve disorder characterized by optic neuritis occurring in conjunction with transverse myelitis; Optic neuritis is characterized by inflammation and swelling of the nerves in the eyes that transmit impulses from the retinas to the brain (optic nerves); Transverse myelitis is characterized by inflammation and swelling of the nerves in the spinal cord; Most individuals with Devic disease have an initial phase of the disorder consisting of a slight fever, sore throat and/or head cold; Affected individuals may also experience loss of clear vision (acuity), mild paralysis (usually of the lower limbs), and loss of bladder and bowel control; Devic disease may occur spontaneously, or in conjunction with multiple sclerosis or systemic lupus erythematosus-----------[NORD 2005]----------

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External Links Related to Optica neuromyelitis/Devic disease
Google
Wikipedia
Merck
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PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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