Disease Information for Olanzepine (Zyprexa) Administration/Toxicity

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Clinical Manifestations
Signs & Symptoms
Dizzy on Standing/Giddy Response
Orthostatic drop in blood pressure
Dry mouth/Mucous membranes
Motor restlessness
Akathisia
Athetosis
Choreoathetoid movement
Dystonia, acquired
Odd body posturing
Seizures
Stupor/poor reponse to stimulus
Tremor
Unable to sit still/restlessness
Weight gain
Mydriasis/wide pupils
Laboratory Tests
Abnormal Lab Findings - Increased
URINE Myoglobin
Associated Diseases & Rule outs
Associated Disease & Complications
Cardiac arrhythmias
Convulsions (grand mal)
Drug induced Acute dystonia reaction
Drug Induced Choreoathetosis
Drug induced Movement disorder
Drug induced Orthostatic hypotension
Drug induced Seizures
Hyperglycemia
Myoglobinuria
Neuroleptic malignant syndrome
Obesity
Opiate/Morphine overdose toxidrome
Orthostatic hypotension syndrome
Orthostatic syncope Hypotension
Rhabdomyolysis
Sedation/torpor induced
Tardive dyskinesia syndrome
Urinary bladder retention
Disease Mechanism & Classification
Drugs
DRUG/Antipsychotic/neuroleptic drug (example)
DRUG/Anti-Schizophrenia medication (example)
DRUG/Atypical anti-psychotic neuroleptic drugs
DRUG/Phenothiazine class drug (example)
DRUG/Psychoactive/sedative drug (category)
DRUG/Blocks Serotonin/Dopamine receptors
DRUG/Lowers seizure threshold
Process
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
Synonyms
Synonym
Olanzapine (Zyprexa) admin, Brand name/ Symbyax (Olanzapine-Fluoxetine) combination, Brand name/Zyprexa (Olanzepine)
Treatment
Drug Dosage
DRUG/.$$$ Expensive medication
DRUG/.$$$$$ Most Expensive
DRUG/2000 New drug (RX)
DRUG/Dose 10 mgm (Unit/Pill/Capsule size)
DRUG/Dose 2.5 mgm (Unit/Pill/Capsule size).
DRUG/Dose 5 mgm (Unit/Pill/Capsule size)
DRUG/Dose once daily (RX)
DRUG/Oral medication (ex)
Definition

Synthetic Thorazine-like drug;class of neuroleptic drugs for anti-psychosis effect;oral and parenteral drug;causes sedation, tardive dyskinesia; basal ganglia effects;wide margin of safety

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External Links Related to Olanzepine (Zyprexa) Administration/Toxicity
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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