Disease Information for Nocardia infection

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Clinical Manifestations
Signs & Symptoms
Draining sinus tract/cutaneous
Night sweats
Septic Abrasion Trauma
Adenopathy/adenitis - fistula/drainage
Regional adenopathy
Tender adenopathy/unilateral
Chills
Chronically ill patient/signs
Constitutional symptoms
Malaise
Weight Loss
Clinical Presentation & Variations
Presentation/Chronic Painful Infected Indurated Leg
AIDS with Brain mass
AIDS with Chest Infection
Presentation/AIDS Abnormal Chest Xray
Disease Progression
Course/Chronic disorder
Course/Chronic only
Course/Relapsing
Demographics & Risk Factors
Established Disease Population
Patient/AIDS established population
Patient/Chemotherapy/cancer
Patient/Corticosteroid treatment
Patient/Heart transplant
Patient/Bone marrow transplant recipient
Patient/Immune compromised/Immune suppressed
Occupational Factors
Occupation/Farmer/Agriculture
Event, Activity, Behavioral & Seasonal Factors
Activity/Gardening/in the garden situation
Sex & Age Groups
Population/Adult/all
Population/Male
Laboratory Tests
Microbiology & Serology Findings
Microlab/Culture slow relatively
Microlab/Acid fast bacteria/specimen
Microlab/Branching rods/bacteria
Microlab/Culture slow/2-3 weeks growth
Microlab/Difficult agent to culture
Microlab/Gram positive bacteria
Microlab/Gram-positive bacillus seen
Microlab/Nocardia brasiliensis isolation
Microlab/Nocardia asteroides isolation
Microlab/Nocardia otitidiscaviarum isolation
Diagnostic Test Results
Pathology
BX/Skin biopsy/Abnormal
BX/Liver biopsy/Granulomas in liver
PATH/Granulomatous tissue/specimen
PATH/Hyphae in tissue
CT Scan
CT Scan /Brain Mass in AIDS
X-RAY
Xray/Chest abnormal
Xray/Cavitation/Cavitary lung lesion/Chest
Xray/Chest/Lung fields/Abnormal
Xray/Multiple cavitary lesions of lungs/Chest
Xray/Thick-walled cavitating lung lesions/multiple/Chest
Associated Diseases & Rule outs
Rule Outs
Actinomycosis
Pneumonia, abscessing staphylococcal
Sporotrichosis
Associated Disease & Complications
Endocarditis, infective
Fungal Brain Abscess
Glucocorticoid Deficiency
Granulomatous liver/hepatitis syndrome
Lung abscess
Lymphangitis
Necrotizing infections
Necrotizing pneumonia/Lung infection
Nocardia Brain Abscess
Nocardia, pulmonary
Nocardiosis
Pneumonia
Pneumonia, bacterial
Pneumonia, unresolved/Chronic
Pneumonia/Bronchopneumonia
Tuberculosis
Chronic Lymphadenitis
Disease Synergy - Causes
Synergy/Corticosteroid treatment
Synergy/Immune deficiency
Disease Mechanism & Classification
Specific Agent
AGENT/Actinobacterium (ex)
AGENT/Bacteria (category)
AGENT/Contagion not reported/unlikely (ex)
AGENT/Fungus (category)
AGENT/Minimally Contagious/infectious
AGENT/Nocardia Species/Actinobacter
AGENT/Saprophytic organism (ex)
AGENT/Ubiqitous in soil
Pathophysiology
Pathophysiology/Granulomatous liver disease
Pathophysiology/Necrotizing lung infection
Process
PROCESS/Infection/agent specific (category)
PROCESS/Inflammatory/Granulomatous disease (ex)
PROCESS/Granulomatous Disease
Treatment
Drug Therapy - Indication
RX/Amikacin (Amikin)
RX/Antibiotic
RX/Cefotaxime (Claforan)
RX/Ceftriaxone (Rocephin)
RX/Minocycline (Minocin)
RX/Prolonged course of antibiotics
RX/Sulfa drug
RX/Sulfisoxazole (Gantrisin)
RX/Sulfonamides
RX/Trimethoprim-sulfamethoxazole (Bactrim)
Definition

Infections with bacteria of the genus NOCARDIA; Nocardiosis ; Lung Nocardiosis; Nocardiosis is an infectious pulmonary disease characterized by abscesses in the lungs; These abscesses may extend through the chest wall; The infection is spread through the body via the bloodstream by a microorganism called Nocardia asteroides; [NORD]----------------------------------------------

Nocardia species are found worldwide in the soil Nocardiosis is found most commonly in patients who are compromised (eg, receiving steroids,

immunosuppressive therapy, lymphoma, leukemia, lung cancer, and other pulmonary infections Other underlying conditions associated with nocardiosis are pemphigus vulgaris, Whipple"s disease, Goodpasture"s syndrome, Cushing"s disease, cirrhosis, ulcerative colitis, and rheumatoid arthritis Between 500 to 1000 new cases are diagnosed each year in the United States; Approximately 2% of patients with AIDS develop nocardiosis; Occur more commonly in men than in women (2:1).Adults > children; The most common presentation of nocardiosis is pneumonia (75%) with fever, chills, dyspnea, and a productive cough; Presentation can be acute, subacute, or chronic; Nocardiosis should be suspected if soft tissue abscesses or CNS tumors or abscesses form in conjunction with the pulmonary infection; Pulmonary infection may spread into the pericardium, ediastinum, and superior vena cava; Infection can follow skin puncture by a thorn or splinter with

inoculation and introduction of the microorganism and lead to: Cellulitis; Lymphocutaneous nodules appearing along lymphatic sites draining the infected puncture wound ; Mycetoma (Madura foot), a chronic deep nodular infection usually involving the hands or feet that can cause skin breakdown, fistula formation, and spread along the fascial planes to infect surrounding skin, subcutaneous tissue and bone; The CNS system is infected in approximately one third of all cases; Brain abscesses is the most common pathologic finding; [Cecil 2004]

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External Links Related to Nocardia infection
Google
Wikipedia
Merck
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PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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