Disease Information for Nitrofurantoin (Macrodantin/Furadantin)

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Clinical Manifestations
Signs & Symptoms
Rash
Motor and sensory neuropathy/Polyneuropathy signs
Paresthesias
Clinical Presentation & Variations
Presentation/Progressive Motor Sensory Polyneuropathy
Demographics & Risk Factors
Established Disease Population
Patient/G6PD RBC hemolysis
Laboratory Tests
Abnormal Lab Findings (Non Measured)
Heinz bodies RBC (Lab)
Heinz Body Prep/RBCs Positive
URINE Color Brown
URINE Color Yellow Brown
Abnormal Lab Findings - Decreased
Folic acid/Folate (Lab)
Recalcification time (Lab)
Reduced glutathione, RBC (Lab)
Abnormal Lab Findings - Increased
PLEURAL Eosinophiles
Diagnostic Test Results
Pathology
BX/Liver biopsy/Granulomas in liver
X-RAY
Xray/Chest abnormal
Xray/Chest/Lung fields/Abnormal
Xray/Pneumonitis/pattern no infection/Chest
Associated Diseases & Rule outs
Rule Outs
Pneumonia/Bronchopneumonia
Associated Disease & Complications
Alveolar hemorrhage syndrome
Anemia, hemolytic, toxic
Autoimmune hepatitis
Chronic hepatitis/Active
Dermatitis/Chronic rash
Drug induced Hepatic toxicity
Drug induced Hepatitis, idiosyncratic
Drug induced Interstitial Lung disease.
Drug induced Lung disease.
Drug induced Neutropenia.
Drug induced Peripheral neuropathy.
Drug induced Pleural effusion
Drug induced Pulmonary fibrosis.
Drug induced Rash/eruption/herbal
Drug rash/Drug induced rash
Eosinophilic pneumonia/prolonged
Furadantin lung/Nitrofurantoin toxicity
Glucose-6-PD Hemolytic crisis ('triggers')
Granulocytopenia/Neutropenia
Granulomatous liver/hepatitis syndrome
Hemolysis anemia/acute/active
Interstitial lung involvement/manifestation
Pancreatitis, acute
Pericardial effusion
Peripheral neuropathy
Pleural Effusion
Polyneuritis
Pseudotumor cerebri
Pulmonary eosinophilia syndrome
Pulmonary fibrosis
Pulmonary Interstitial fibrosis, secondary
Respiratory distress (adult) syndrome
Toxic hepatitis
Toxic peripheral/polyneuropathy
Chronic Hepatitis
Polyneuropathy
Disease Mechanism & Classification
Drugs
DRUG/Antibiotic/antibacterial drug (example)
DRUG/Antibiotic/Antimicrobial drugs (category)
DRUG/Older medication/little used
DRUG/Safe in pregnancy patient (B)
DRUG-Liver metabolism/bile excretion
Pathophysiology
Pathophysiology/Bilirubinemia/neonatal/kernicterus risk
Pathophysiology/Hemolysis
Pathophysiology/Granulomatous liver disease
Pathophysiology/Chronic intrinsic restrictive lung
Pathophysiology/Interstitial lung disorder (ex).
Process
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
Synonyms
Synonym
2 4 Imidazolidinedione 1 (((5 nitro 2 furanyl)methylene)amino), NITROFURANTOIN, Nitrofurantoin (product), Nitrofurantoin (substance), NITROFURANTOIN PREPARATION, Brand name/Furadantin (Nitrofurantoin), Brand name/Furatoin (Nitrofurantoin), Brand name/Ivadantin (Nitrofurantoin), Brand name/Macrobid (Nitrofurantoin), Brand name/Macrodantin (Nitrofurantoin), Brand name/Trantoin (Nitrofurantoin)
Treatment
Drug Dosage
DRUG/.1990 or before
DRUG/Dose 100 mgm (Unit/Pill/Capsule size)
DRUG/Dose 50 mgm (Unit/Pill/Capsule size)
DRUG/Dose Extended time release/XT/SA (example)
DRUG/Dose liquid/syrup/suspension form
DRUG/Dose QID Medication
DRUG/Generic available
DRUG/Not approved for children/pediatrics
DRUG/Oral medication (ex)
Definition

Furacin antibacterial antibiotic drug; used for UTI suppression; causes pulmonary interstitial disease and fibrosis;oral preparation;lttle used (also used as burn unction)

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External Links Related to Nitrofurantoin (Macrodantin/Furadantin)
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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