Disease Information for Neurofibroma

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Clinical Manifestations
Signs & Symptoms
Breast Swelling Bilateral
Brown skin discoloration
Cafe au lait pigmentation
Skin nodules/Subcutaneous nodules
Subcutaneous nodules
Subcutaneous nodules in Children
Subcutaneous/mass
Large tongue/macroglossia
Swollen Limb
Popliteal mass/swelling
Disease Progression
Course/Chronic disorder
Course/Chronic only
Diagnostic Test Results
CT Scan
CT Scan/Mediastinal Abnormality/Chest
X-RAY
Xray/Chest abnormal
Xray/Chest/Lung fields/Abnormal
Xray/Mediastinal mass/Chest
Xray/Retrocardiac shadow/mass/Chest
Xray/Posterior mediastinal mass/Chest
Xray/Sphenoid ridge/sinus erosion/Sinus
Xray/Optic canal enlargement/Skull
X-RAY With contrast
Myelogram Abnormal
Associated Diseases & Rule outs
Associated Disease & Complications
Gynecomastia
Disease Mechanism & Classification
Class
CLASS/Neurologic (category)
Pathophysiology
Pathophysiology/Extramedullary Spinal Tumor
Pathophysiology/Subdural Spinal Mass
Process
PROCESS/Benign tumor (ex).
PROCESS/Neoplastic (category)
PROCESS/Primary soft tissue tumor (ex)
PROCESS/Primary spinal cord neoplasm (ex)
Definition

A moderately firm, benign, encapsulated tumor resulting from proliferation of SCHWANN CELLS and FIBROBLASTS that includes portions of nerve fibers. The tumors usually develop along peripheral or cranial nerves and are a central feature of NEUROFIBROMATOSIS 1, where they may occur intracranially or involve spinal roots. Pathologic features include fusiform enlargement of the involved nerve. Microscopic examination reveals a disorganized and loose cellular pattern with elongated nuclei intermixed with fibrous strands. (From Adams et al., Principles of Neurology, 6th ed, p1016)

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External Links Related to Neurofibroma
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Wikipedia
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Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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