Disease Information for Neuroblastoma, CNS

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Clinical Manifestations
Signs & Symptoms
High blood pressure child
High blood pressure/sign
Ataxia
Nystagmus
Staggering Gait
Constitutional symptoms
Opsoclonus/chaotic eye movements
True Vertigo Sign Confirmed
Clinical Presentation & Variations
Presentation/Ataxia in a Child Acute
Disease Progression
Course/Chronic disorder
Course/Chronic only
Laboratory Tests
Abnormal Lab Findings (Non Measured)
Chromosomal abnormality (Lab)
Abnormal Lab Findings - Increased
Catecholamines serum (Lab)
Dopamine (Lab)
Norepinephrine, plasma (Lab)
Vanillyl-Mandelic Acid/VMA (Lab)
URINE Arylsulfatase
URINE Catecholamines
URINE Homovanillic acid
URINE Metanephrines
URINE VMA
Diagnostic Test Results
Isotope Scan
Isotope/MIBG I131 scan abnormal (metaiodobenzylguanidine)
CT Scan
MRI/Head Scan Abnormal
Associated Diseases & Rule outs
Rule Outs
Meningioma
Associated Disease & Complications
Encephalopathy, myoclonic infantile (Kinsbourne)
Encephalopathy, myoclonic, infantile
Hypertension in a child
Intracranial Mass/Effect
Myoclonic encephalopathy/childhood
Neuroblastoma/CNS
Ataxia Disorder
Intracranial Lesion
Mass in Brain
Disease Mechanism & Classification
Class
CLASS/Brain/CNS disorder (ex)
CLASS/Neurologic (category)
Pathophysiology
Pathophysiology/Neural crest cells/APUD tumors (ex)
Pathophysiology/Oncogene WT1/locus 11p
Pathophysiology/Radioresistant malignancy/relative
Pathophysiology/CNS mass lesion effect
Process
PROCESS/Malignancy in childhood (ex)
PROCESS/Malignancy/cancer (ex)
PROCESS/Neoplastic (category)
PROCESS/Congenital neoplasm (ex)
Treatment
Drug Therapy - Indication
RX/Chemotherapy combination/protocol
RX/Chemotherapy(cancer)
Definition

Neuroblastomas are neural tumors and abnormalities that have cell origins from the neural crest; ICD-9CM CODES; 194_0 Neuroblastoma, unspecified site; 8% of all solid tumors of childhood; Male >female ratio Childhood; Infants and children; N-myc protooncogene; loss of short arm chromosome 1 (1p36) found in some children; CLINICAL: Mass in abdomen, neck, or chest; Spinal cord compression; Dancing eyes; Chronic pain; Ecchymosis around eyes; Weight loss; Fever; DIFFERENTIAL: Other childhood tumors; Wilms’ tumor; Diagnosis: Biopsy of tumor; Urinary catecholamines; Bone marrow aspiration; CT scan or MRI abdomen/chest or head; there is hope for recovery with aggressive treatment ;Surgery; Multiagent chemotherapy (eg, cyclophosphamide, vincristine, dacarbazine, melphalan, doxorubicin, cisplatin); Radiotherapy ;either death or cure ;Overall survival is >40% Survival in stage I is >95%, whereas survival in stage II is <20% [Evans classification];-------[Ferri"s Clinical advisor 2005]--------

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External Links Related to Neuroblastoma, CNS
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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