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Disease Information for Nephrogenic diabetes insipidus
- Clinical Manifestations
- Signs & Symptoms
- Excess Thirst in Children
- Excessive thirst/polydipsia
- Dry mouth/Mucous membranes
- Altered mental status Mental status change
- Neurologic manifestations/signs
- Sudden unconsciousness
- Bed wetting
- Diuresis/Large urine volumes
- Nocturia
- Nocturia in Children
- Nocturia in Elderly
- Polyuria
- Polyuria and polydipsia
- Urine Frequency
- Episodic symptoms/events
- Fever
- Fever Febrile Possible
- Flu-Like Syndrome
- High body temperature
- Infant/salty taste
- Nocturnal water drinking
- Short stature
- Short stature Child
- Thirst Increased
- Water drinking increased
- Typical Clinical Presentation
- Males sicker than females/characteristic
- Disease Progression
- Course/Chronic disorder
- Course/Chronic only
- Demographics & Risk Factors
- Population Group
- Child
- Infant
- Population/Pediatrics population
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- Population/Boy patient
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- Population/Infant male
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- Laboratory Tests
- Abnormal Lab Findings (Non Measured)
- URINE Isosthenuria/mid-range SPGR
- Acute inflammatory markers elevated (Lab)
- Inappropriate dilute urine/low specific gravity (Lab)
- Inappropriate urine low osmolality (Lab)
- URINE Sodium constantly low
- URINE Specific gravity fixed/1.010
- Abnormal Lab Findings - Decreased
- URINE Osmololality
- URINE Specific gravity
- Abnormal Lab Findings - Increased
- ADH/Antidiuretic Hormone/Vasopressin/Oxytocin level (Lab)
- Osmolality, serum (Lab)
- Sodium, serum (Lab)
- Diagnostic Test Results
- Other Tests & Procedures
- TEST/ADH challenge failure/renal non-responsive
- X-RAY With contrast
- IVP/Ureterectasis bilateral/without obstruction
- Associated Diseases & Rule outs
- Rule Outs
- Diabetes insipidus
- Neonatal Sepsis Syndrome
- Associated Disease & Complications
- Arthritis, gouty type
- Constipation
- Dehydration
- Demeclocycline (Declomycin) effect/toxicity
- Diabetes insipidus
- Eneuresis Bed Wetting
- Enuresis, functional
- Gout attacks/acute gouty arthritis
- Hypernatremia
- Hyperosmolar state
- Isosthenuria syndrome
- Metabolic encephalopathy
- Nephrogenic diabetes insipidus
- Disease Mechanism & Classification
- Class
- CLASS/Pediatric disorders (ex)
- CLASS/Endocrine gland (category)
- CLASS/Renal tubule defect/manifestation (ex)
- CLASS/Renal/kidney involvement/disorder (ex)
- CLASS/Urologic (category)
- Pathophysiology
- Pathophysiology/Gene locus Chromosome X.
- Pathophysiology/Genomic indentifiers (polymorphism/snip/mutations)
- Pathophysiology/X-linked dominant allele/Heterozygous
- Pathophysiology/Blood volume/decrease/low
- Pathophysiology/Hereditary disease renal effect
- Pathophysiology/Renal ADH receptor failure/absence
- Pathophysiology/Renal concentration capacity defect
- Pathophysiology/AQP2 Gene mutation
- Pathophysiology/AVPR2 Gene mutation
- Process
- PROCESS/Congenital/developmental (category)
- PROCESS/Endocrine/humoral disorders (category)
- PROCESS/Hereditofamilial (category)
- PROCESS/INCIDENCE/Rare disease (ex)
- PROCESS/Paraneoplastic disorder (ex)
- PROCESS/Sex-linked (X-linked) recessive inheritance (ex)
- PROCESS/Vegetative-Autonomic/Endocrine (category)
- PROCESS/X-Linked dominant inheritance (ex)
- Treatment
- Drug Therapy - Contraindication
- RX/Demeclocycline (Declomycin)
- Drug Therapy - Indication
- RX/Thiazide/hydrochlorothiazide
- Other Treatments
- TX/Salt restriction
- Definition
-
A polyuric disorder characterized by normal rates of renal filtration and solute excretion, but a persistent hypotonic urine. This condition is due to the failure of renal tubules to respond to antidiuretic hormones, such as vasopressin, to reduce urine volume. Tubular insensitivity to vasopressin can result from genetic defects, diseases, drug effects, or may occur with pregnancy.
(Edit)
- External Links Related to Nephrogenic diabetes insipidus
- Wikipedia
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- PubMed (National Library of Medicine)
- NGC (National Guideline Clearinghouse)
- Medscape (eMedicine)
- Harrison's Online (accessmedicine)
- NEJM (The New England Journal of Medicine)
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