Disease Information for Nephrogenic diabetes insipidus

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Clinical Manifestations
Signs & Symptoms
Excess Thirst in Children
Excessive thirst/polydipsia
Dry mouth/Mucous membranes
Altered mental status Mental status change
Neurologic manifestations/signs
Sudden unconsciousness
Bed wetting
Diuresis/Large urine volumes
Nocturia
Nocturia in Children
Nocturia in Elderly
Polyuria
Polyuria and polydipsia
Urine Frequency
Episodic symptoms/events
Fever
Fever Febrile Possible
Flu-Like Syndrome
High body temperature
Infant/salty taste
Nocturnal water drinking
Short stature
Short stature Child
Thirst Increased
Water drinking increased
Typical Clinical Presentation
Males sicker than females/characteristic
Disease Progression
Course/Chronic disorder
Course/Chronic only
Demographics & Risk Factors
Population Group
Child
Infant
Population/Pediatrics population
Sex & Age Groups
Population/Boy patient
Population/Child
Population/Children/all
Population/Infant
Population/Infant male
Population/Male
Laboratory Tests
Abnormal Lab Findings (Non Measured)
URINE Isosthenuria/mid-range SPGR
Acute inflammatory markers elevated (Lab)
Inappropriate dilute urine/low specific gravity (Lab)
Inappropriate urine low osmolality (Lab)
URINE Sodium constantly low
URINE Specific gravity fixed/1.010
Abnormal Lab Findings - Decreased
URINE Osmololality
URINE Specific gravity
Abnormal Lab Findings - Increased
ADH/Antidiuretic Hormone/Vasopressin/Oxytocin level (Lab)
Osmolality, serum (Lab)
Sodium, serum (Lab)
Diagnostic Test Results
Other Tests & Procedures
TEST/ADH challenge failure/renal non-responsive
X-RAY With contrast
IVP/Ureterectasis bilateral/without obstruction
Associated Diseases & Rule outs
Rule Outs
Diabetes insipidus
Neonatal Sepsis Syndrome
Associated Disease & Complications
Arthritis, gouty type
Constipation
Dehydration
Demeclocycline (Declomycin) effect/toxicity
Diabetes insipidus
Eneuresis Bed Wetting
Enuresis, functional
Gout attacks/acute gouty arthritis
Hypernatremia
Hyperosmolar state
Isosthenuria syndrome
Metabolic encephalopathy
Nephrogenic diabetes insipidus
Disease Mechanism & Classification
Class
CLASS/Pediatric disorders (ex)
CLASS/Endocrine gland (category)
CLASS/Renal tubule defect/manifestation (ex)
CLASS/Renal/kidney involvement/disorder (ex)
CLASS/Urologic (category)
Pathophysiology
Pathophysiology/Gene locus Chromosome X.
Pathophysiology/Genomic indentifiers (polymorphism/snip/mutations)
Pathophysiology/X-linked dominant allele/Heterozygous
Pathophysiology/Blood volume/decrease/low
Pathophysiology/Hereditary disease renal effect
Pathophysiology/Renal ADH receptor failure/absence
Pathophysiology/Renal concentration capacity defect
Pathophysiology/AQP2 Gene mutation
Pathophysiology/AVPR2 Gene mutation
Process
PROCESS/Congenital/developmental (category)
PROCESS/Endocrine/humoral disorders (category)
PROCESS/Hereditofamilial (category)
PROCESS/INCIDENCE/Rare disease (ex)
PROCESS/Paraneoplastic disorder (ex)
PROCESS/Sex-linked (X-linked) recessive inheritance (ex)
PROCESS/Vegetative-Autonomic/Endocrine (category)
PROCESS/X-Linked dominant inheritance (ex)
Treatment
Drug Therapy - Contraindication
RX/Demeclocycline (Declomycin)
Drug Therapy - Indication
RX/Thiazide/hydrochlorothiazide
Other Treatments
TX/Salt restriction
Definition

A polyuric disorder characterized by normal rates of renal filtration and solute excretion, but a persistent hypotonic urine. This condition is due to the failure of renal tubules to respond to antidiuretic hormones, such as vasopressin, to reduce urine volume. Tubular insensitivity to vasopressin can result from genetic defects, diseases, drug effects, or may occur with pregnancy.

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External Links Related to Nephrogenic diabetes insipidus
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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