Disease Information for Nephritis, non allergic interstitial

Clinical Manifestations
Signs & Symptoms
Excessive thirst/polydipsia
Nocturia in Elderly
Acutely ill patient/signs
Thirst Increased
Disease Progression
Course/Chronic disorder
Demographics & Risk Factors
Past History
Past history/Radiation/abdomen
Laboratory Tests
Abnormal Lab Findings (Non Measured)
URINE Isosthenuria/mid-range SPGR
Renal function abnormalities (Lab)
URINE Dipstick /Blood abnormal
URINE Dipstick/Leukocytes Positive
URINE Pyuria
URINE Pyuria with negative cultures
URINE Sediment/Urinalysis abnormal
URINE Specific gravity fixed/1.010
Abnormal Lab Findings - Decreased
BUN/Creatinine ratio (Lab)
Creatine clearance (Lab)
URINE Specific gravity
Abnormal Lab Findings - Increased
BUN/Blood urea nitrogen (Lab)
Creatinine, serum (Lab)
Fractional excretion Sodium (Lab)
URINE Casts/Protein casts
URINE Epithelial/round cells
URINE Leukocyte casts
URINE Leukocytes
URINE Protein (Albumin)
URINE Red blood cells
Diagnostic Test Results
BX/Renal Abnormal
BX/Renal Cortex tubulointerstitial nephritis/acute
CT Scan
CT Scan/Renal/No contrast/Small kidneys
X-RAY With contrast
IVP/Papillary destruction/amputation
IVP/Small kidneys bilateral
Ultrasound/Renal/Kidneys echogenic cortex bilateral
Associated Diseases & Rule outs
Associated Disease & Complications
Acute Renal Failure
Acute Tubulointerstitial Nephropathy
Isosthenuria syndrome
Nephritis tubulointerstitial
Nephritis, interstitial
Nephrogenic diabetes insipidus
Renal Failure Chronic
Renal tubular acidosis, distal
Renal tubule acidosis, acquired
Salt-losing nephritis
Proteinuria in Elderly
Disease Mechanism & Classification
CLASS/Primary renal disease (ex)
CLASS/Renal/kidney involvement/disorder (ex)
CLASS/Urologic (category)
Pathophysiology/Defective Potassium excretion/renal
Pathophysiology/Renal concentration capacity defect
PROCESS/Inflammatory/infection (ex)
PROCESS/Reference organ/system (category)
Acute interstitial nephritis, Acute interstitial nephritis (disorder), Acute T I N, Acute tub interstitial nephrit, Acute tubulo interstitial nephritis, Acute tubulointerstitial disease, AIN Acute interstit nephrit, AIN Acute interstitial nephritis, ATIN Acute tub interst nephr, ATIN Acute tubulo interstitial nephritis, INTERSTITIAL NEPHRITIS ACUTE, NEPHRITIS ACUTE INTERSTITIAL, NEPHRITIS INTERSTITIAL ACUTE, Synonym/Acute tubulointerstitial nephritis syndrome
Drug Therapy - Indication
SX/Renal biopsy

Diagnosis: Fever; Transient maculopapular rash; Acute renal insufficiency; Pyuria (including eosinophiluria), white blood cell casts, and hematuria; Acute interstitial nephritis accounts for 10-15% of cases of intrinsic renal failure; An interstitial inflammatory response with edema and possible tubular cell damage is the typical pathologic finding; Cell-mediated immune reactions prevail over humoral responses; T lymphocytes can cause direct cytotoxicity or release lymphokines that recruit monocytes and inflammatory cells; Although drugs account for over 70% of cases, acute interstitial nephritis also occurs in infectious diseases, immunologic disorders, or as an idiopathic condition; The most common drugs are penicillins and cephalosporins, sulfonamides and sulfonamide-containing diuretics, NSAIDs, rifampin, phenytoin, and allopurinol; Infectious causes include streptococcal infections, leptospirosis, cytomegalovirus, histoplasmosis, and Rocky Mountain spotted fever; Immunologic entities are more commonly associated with glomerulonephritis, but systemic lupus erythematosus, Sjögren"s syndrome, sarcoidosis, and cryoglobulinemia can cause interstitial nephritis; Clinical features can include fever (> 80%), rash (25- 50%), arthralgias, and peripheral blood eosinophilia (80%); The urine often contains red cells (95%), white cells, and white cell casts; Proteinuria can be a feature, particularly in NSAID-induced interstitial nephritis but is usually modest; Eosinophiluria can be detected by Wright"s or Hansel"s stain; Acute interstitial nephritis often carries a good prognosis; Recovery occurs over weeks to months, but acute dialytic therapy may be necessary in up to one-third of all patients before resolution; Patients rarely progress to ESRD; Those with prolonged courses of oliguric failure and advanced age have a worse prognosis; Treatment consists of supportive measures and removal of the inciting agent; If renal failure persists after these steps, a short course of corticosteroids can be given; Short-term, high-dose methylprednisolone 4 days or prednisone 2 weeks followed by a prednisone taper can be used in these more severe cases of drug-induced interstitial nephritis; [CMDXRX2005]


External Links Related to Nephritis, non allergic interstitial
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)