Disease Information for Neostigmine (Prostigmin) Administration/Toxicity

Ads
Clinical Manifestations
Signs & Symptoms
Slow pulse/Bradycardia
Diaphoresis profuse/active sweating/acute
Excess Sweating Children
Hyperhidrosis/Chronic sweating excess
Sweating Excess Perspiration
Active Bowel Sounds
Borborygmi/Bowel sound increased
Cholinergic symptoms/signs
Lacrimation/excess tearing
Tearing
Typical Clinical Presentation
Coma with cholinergic ( SLUD) signs
Laboratory Tests
Abnormal Lab Findings - Increased
Acetyl choline level (Lab)
Diagnostic Test Results
EKG (ECG)
EKG/Widened QRS pattern (ECG)
EKG/AV Nodal Block/Complete
EKG/Changes/abnormalities (ECG)
Associated Diseases & Rule outs
Associated Disease & Complications
Bradyarrhythmias
Cardiac conduction defects
Cholinergic crisis/toxidrome
Heart block, complete
Disease Mechanism & Classification
Drugs
DRUG/Acetylcholinesterase inhibitor
DRUG/Anti-Myasthenia Gravis medication (ex)
DRUG/Cholinergic agonist drug/effect (example)
DRUG/Enteric/gut motor stimulation
DRUG/Important Acute care drugs (example)
DRUG/Intensivist (ICU care)
DRUG/Parasympatheticomemitic effect (ex)
DRUG/Lowers seizure threshold
Pathophysiology
Pathophysiology/Acetyl choline accumulation
Pathophysiology/Peristalsis increased
Pathophysiology/Neuromuscular irritability
Process
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
Toxin
TOXIN/Decreases Heart Rate
TOXIN/SLUD response(sial/lacr/urine/dia)
Synonyms
Synonym
Benzenaminium 3 (((dimethylamino)carbonyl)oxy) N N N trimethyl, NEOSTIGMINE, Neostigmine (neuromusc transm), Neostigmine (neuromuscular transmission), Neostigmine (neuromuscular transmission) (product), Neostigmine (neuromuscular transmission) (substance), Neostigmine (product), Neostigmine (substance), NEOSTIGMINE PREPARATION, Proserine, Prozerin, Synstigmin, Brand name/Prostigmin (Neostigmine)
Treatment
Drug Dosage
DRUG/.$$$ Expensive medication
DRUG/Dose 15 mgm (Unit/Pill/Capsule size)
DRUG/Injectable medication (parenteral)
DRUG/Injectable preparation only
DRUG/Intramuscular injection RX
DRUG/Subcutaneous administration medication
Definition

Anticholinesterase inhibitor drug used in acute myasthenia gravis; ACH Inhibitors can induce cholinergic crisis syndrome; This is an injectable drug; Used also in

certain poisonings

(Edit)

External Links Related to Neostigmine (Prostigmin) Administration/Toxicity
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
Ads