Disease Information for Neonatal myasthenia

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Clinical Manifestations
Signs & Symptoms
Hyperextensable Joints Infant
Tongue Protrudes Infant
Central hypotonia, infants
Delay Sitting Unsupported Infant
Hypotonia
Mouth Hangs Open Infant
Muscles Soft/Doughy Infant
Proximal muscle weakness
Rolling Over Delay Infant
Babkin infant sign/Abnormal
Delayed walking milestone/child
Development Motor Skills (Milestones) Delayed
Galant Infant reflex/Abnormal
Head Neck Floppy Infant Hypotonia Sign
Hyporeflexia/DTRs decreased
Infant Head Support Delay
Low APGAR Score Newborn
Moro reflex Poor/Absent Infant
Palmar Grasp infant Reflex Abnormal
Paralysis
Primitive infant reflexes/Abnormal
Rooting infant sign/Abnormal
Swimming infant reflex/Abnormal
Tonic Neck Infant reflex/Abnormal
Weakness/Diffuse motor loss
Shallow breathing
Shallow Breathing Infant
Voice Alteration
Voice Alteration in Children
Voice change/disturbance/Unusual
Weakness
Ptosis (blepharoptosis)
Demographics & Risk Factors
Population Group
Child
Infant
Population/Pediatrics population
Sex & Age Groups
Population/Child
Population/Child-Infant Only
Population/Children/all
Population/Infant
Population/Neonate-newborn
Laboratory Tests
Abnormal Lab Findings - Increased
Anti-AcetylCholine receptor antibody/ACh (Lab)
Diagnostic Test Results
Electrodiagnosis
EMG/Abnormal findings
Associated Diseases & Rule outs
Rule Outs
Muscular dystrophy
Myotonia atrophica
Associated Disease & Complications
Esotropia
Neonatal Hypotonia/Floppy Baby Syndrome
Ophthalmoplegia
Respiratory muscle weakness
Disease Mechanism & Classification
Class
CLASS/Pediatric disorders (ex)
CLASS/Fetal/conceptual products (category)
CLASS/Muscle/tendon/extremities (category)
Pathophysiology
Pathophysiology/Gene locus 11p11.2-p11.1
Pathophysiology/Gene locus 17p12-p11
Pathophysiology/Gene locus 17p13
Pathophysiology/Gene locus 17p13-p12
Pathophysiology/Gene locus Chromosome 17
Pathophysiology/Gene Locus Identified/OMIM database
Pathophysiology/Genomic indentifiers (polymorphism/snip/mutations)
Pathophysiology/Lung Ventilation Neuromuscular
Process
PROCESS/Complicating disorder (ex)
PROCESS/Vegetative-Autonomic/Endocrine (category)
Treatment
Drug Therapy - Contraindication
RX/Magnesium injection
Definition

Neonatal myasthenia is a syndrome of generalized muscle weakness, affecting 12% of infants born to women with myasthenia gravis, due to antibodies passively crossing the placenta; Symptoms resolve in days to weeks as antibody titers decline; Congenital myasthenia is a rare autosomal recessive disorder of neuromuscular transmission beginning in childhood; Acetylcholine-receptor antibodies are absent, so the disease is not autoimmune----[Merck Manual 17th]------------------------

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External Links Related to Neonatal myasthenia
Google
Wikipedia
Merck
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PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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