Disease Information for Myositis synthetase syndrome/Anti-Jo-1 syndrome

Ads
Clinical Manifestations
Signs & Symptoms
Skin thickening over fingers
Finger tightness/thickening/swelling
Hypotonia
Cellophane crackles/rales at bases sign
Dyspnea
Exertional cyanosis
Pulmonary Crackles
Shortness of breath/SOB
Arthralgias Polyarthralgias
Joint Pains
Joint pains Arthralgias in Elderly
Morning gel stiffness
Shoulder arthritis signs/symptoms
Wrist arthritis/signs
Fever
Fever Febrile Possible
Flu-Like Syndrome
High body temperature
Clinical Presentation & Variations
Fever and High Sed Rate
Disease Progression
Course/Chronic disorder
Course/Chronic only
Demographics & Risk Factors
Established Disease Population
Patient/Dermatomyositis
Population Group
Middle Age Adult
Woman
Event, Activity, Behavioral & Seasonal Factors
Early Morning Events Phenomenon
Sex & Age Groups
Population/Adult Aged Only
Population/Adult/all
Population/Female
Population/Fifties adult
Population/Middle-aged adult
Population/Woman patient
Laboratory Tests
Abnormal Lab Findings (Non Measured)
Acute inflammatory markers elevated (Lab)
SGOT(AST)/SGPT(ALT) Less than 1.0 (Lab)
Transaminase elevation (Lab)
HLA DR3 (Lab)
HLA DRW52 (Lab)
HLA Specific association (Lab)
Abnormal Lab Findings - Decreased
Anti-Ku antibody (labs)
Abnormal Lab Findings - Increased
Anti-EJ Antibody test (labs)
Anti-Jo1 antibody (labs)
Anti-JO-1/RNA (histidyl enzyme) (Lab)
Anti-Mi1 antibody (labs)
Anti-Mi2 antibody (labs)
Anti-OJ Antibody (labs)
Anti-Pl12 antibody (labs)
Anti-PL-7 antibody (labs)
Anti-RNA antibody/Nrnp (Lab)
Anti-SRP Antibody (labs)
Anti-U2SNRNP
Aldolase, serum (Lab)
ALT (SGPT) (Alanine transferase) (Lab)
CPK/CK/Creatine kinase/Creatine phosphokinase (Lab)
Sed Rate/ESR/Sedimentation rate (Lab)
Diagnostic Test Results
Pathology
BX/Lung Abnormal (Biopsy)
Electrodiagnosis
EMG/Abnormal findings
Pulse oximetry/low O2 saturation
X-RAY
Xray/Chest abnormal
Xray/Chest/Lung fields/Abnormal
Associated Diseases & Rule outs
Rule Outs
Dermatomyositis
Myotonia atrophica
Associated Disease & Complications
Arthritis
Bronchiolitis obliterans
Bronchiolitis obliterans/organizing pneumonia/BOOP
Dermatomyositis
Hypoxemia
Hypoxia, systemic
Inflammatory myopathy
Interstitial lung involvement/manifestation
Knee arthritis
Myopathy
Polyarthritis syndrome/Multiple joints/weeks
Polymyositis
Raynaud's syndrome
PolyArthritis
Disease Mechanism & Classification
Pathophysiology
Pathophysiology/Anti-JO1 variant/more joint/lung involvement
Pathophysiology/Exertional O2 desaturation
Pathophysiology/Anti t-RNA synthetase
Process
PROCESS/Allergy/collagen/autoimmune (category)
PROCESS/Collagen disease (ex)
Synonyms
Synonym
Myositis synthetase syndrome Anti Jo 1 syndrome, Synonym/Dermatomyositis [T-RNA synthetase antibody]
Treatment
Drug Therapy - Indication
RX/Corticosteroid (Cortisone)
Definition

Newly described anti Jo-1 autoimmune disease (t-RNA synthetase or antihistidyl t-RNA synthetase); clinically subset of dermatomyositis manifest as interstitial lung disease, myositis, raynauds disease, arthritis of wrists, fingers, knees, and shoulders with fever; treatment corticosteroids

(Edit)

External Links Related to Myositis synthetase syndrome/Anti-Jo-1 syndrome
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
Ads