Disease Information for Myositis, inclusion body

Progressive myopathies characterized by the presence of inclusion bodies on muscle biopsy; Sporadic and hereditary forms have been described; The sporadic form is an acquired, adult-onset inflammatory vacuolar myopathy affecting proximal and distal muscles; Familial forms usually begin in childhood and lack inflammatory changes. Both forms feature intracytoplasmic and intranuclear inclusions in muscle tissue; (Adams et al, Principles of Neurology, 6th ed, pp1409-10)---------------------------------------.Myositis, Inclusion Body; IBM; Inflammatory Myopathy; Inclusion body myositis (IBM) is a rare inflammatory muscular disorder that usually becomes apparent during adulthood; The disorder presents as slow progressive weakness and withering away (atrophy) of the muscles (myositis), especially of the arms and legs; Inclusion body myositis frequently is diagnosed when a patient is unresponsive to therapy prescribed for polymyositis; IBM is characterized by the gradual onset (over months or years) of muscle fatigue and weakness; a clear tendency to strike men more frequently than women; and affecting both the muscles closest to the body’s trunk (proximal) and those farthest from the trunk (distal); Onset is usually after age 50, although it may occur earlier; [NORD]

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