Disease Information for Myositis, inclusion body

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Clinical Manifestations
Signs & Symptoms
Bilateral Shoulder Muscle pain/Weakness
Distal leg weakness
Distal Muscle Weakness
Distal upper extremity weakness
Hypotonia
Muscle Pain
Muscle weakness
Myalgias
Pelvic/limb girdle weakness/bilateral
Proximal lower extremity weakness
Proximal muscle weakness
Proximal symmetrical muscle weakness
Proximal upper extremity weakness
Shoulder/limb girdle weakness/bilateral
Tender or painful muscles/Myalgias
Unable to stand up from sitting position
Weak/Weak as a kitten (symptom)
Weakness/Diffuse motor loss
Dyspnea on exertion
Distal Hyperlaxity
Enervated/extreme acute fatigue
Weakness
Clinical Presentation & Variations
Presentation/Prednisone Corticosteroid Treatment Failure
Disease Progression
Course/Acute
Course/Chronic disorder
Course/Progressive
Course/Progressive/slowly chronic illness
Demographics & Risk Factors
Population Group
Aged Adult
Man
Middle Age Adult
Sex & Age Groups
Population/Adult Aged Only
Population/Adult/all
Population/Elderly Aged
Population/Fifties adult
Population/Male
Population/Man patient
Population/Middle-aged adult
Population/Seventies Adult
Laboratory Tests
Abnormal Lab Findings - Increased
Aldolase, serum (Lab)
Aspartamine aminotransferase (SGOT, AST) (Lab)
CK-MM (Lab)
CPK/CK/Creatine kinase/Creatine phosphokinase (Lab)
Diagnostic Test Results
Pathology
BX/Muscle (ElectroMS) vacuoles/sworles
BX/Muscle Biopsy Abnormal
BX/Muscle biopsy/Inclusion bodies
BX/Muscle biopsy/inflammatory infiltrate/changes
BX/Muscle Electronmicroscopy Abnormal
PATH/Viral inclusion bodies
Electrodiagnosis
EMG/Abnormal findings
Associated Diseases & Rule outs
Rule Outs
Dermatomyositis
Eaton-Lambert syndrome
Muscular dystrophy
Myotonia atrophica
Polymyositis
Associated Disease & Complications
Infectious myopathy
Inflammatory myopathy
Myopathy
Myopathy/secondary/nonspecific
Myositis, inclusion body
Disease Mechanism & Classification
Class
CLASS/Primary organ/system disorder (ex)
CLASS/Muscle disorder (ex)
CLASS/Muscle/tendon/extremities (category)
CLASS/Striated muscle disorder (ex)
Pathophysiology
Pathophysiology/Myositis/Infection
Process
PROCESS/Idiopathic/unclassified/unknown (category)
PROCESS/Infected organ/abscess (category)
PROCESS/Inflammatory/Granulomatous disorder (category)
PROCESS/Inflammatory/infection (ex)
Treatment
Drug Therapy - Indication
RX/Immunoglobulin infusion
Definition

Progressive myopathies characterized by the presence of inclusion bodies on muscle biopsy; Sporadic and hereditary forms have been described; The sporadic form is an acquired, adult-onset inflammatory vacuolar myopathy affecting proximal and distal muscles; Familial forms usually begin in childhood and lack inflammatory changes. Both forms feature intracytoplasmic and intranuclear inclusions in muscle tissue; (Adams et al, Principles of Neurology, 6th ed, pp1409-10)---------------------------------------.Myositis, Inclusion Body; IBM; Inflammatory Myopathy; Inclusion body myositis (IBM) is a rare inflammatory muscular disorder that usually becomes apparent during adulthood; The disorder presents as slow progressive weakness and withering away (atrophy) of the muscles (myositis), especially of the arms and legs; Inclusion body myositis frequently is diagnosed when a patient is unresponsive to therapy prescribed for polymyositis; IBM is characterized by the gradual onset (over months or years) of muscle fatigue and weakness; a clear tendency to strike men more frequently than women; and affecting both the muscles closest to the body’s trunk (proximal) and those farthest from the trunk (distal); Onset is usually after age 50, although it may occur earlier; [NORD]

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External Links Related to Myositis, inclusion body
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PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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