Disease Information for Myelofibrosis, secondary

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Clinical Manifestations
Signs & Symptoms
Splenomegaly
Clinical Presentation & Variations
Anemia with Low Reticulocyte Count
Disease Progression
Course/Chronic disorder
Course/Chronic only
Pancytopenia with Hypocellular Marrow
Pancytopenia with Infiltrated Marrow
Demographics & Risk Factors
Established Disease Population
Patient/Gauchers disease
Laboratory Tests
Microbiology & Serology Findings
Reticulocytosis
Abnormal Lab Findings (Non Measured)
Acanthocytes peripheral smear (Lab)
Left shift/WBC low (Lab)
Left shifted differential smear (Lab)
Leukoerythrobastic pattern/blood smear (Lab)
Macrocytosis/smear (Lab)
Normocytic anemia
Normocytic anemia/low retic count
Normocytic/Normochromic Anemia (Lab)
Abnormal Lab Findings - Decreased
WBC
Cholesterol (Lab)
Hematocrit (Lab)
Hemoglobin (Lab)
Neutrophiles (Lab)
Platelet count (Lab)
RBC/Red Blood Count (Lab)
Reticulocytes (Lab)
WBC/White Blood Cell Count/Leukocytes (Lab)
Abnormal Lab Findings - Increased
Leukocyte Alkaline phosphatase (Lab)
Diagnostic Test Results
Pathology
Bone marrow/Dry tap
BX/Bone Marrow Biopsy/Abnormal
BX/Bone marrow biopsy/hypocellular
BX/Bone biopsy/abnormal
Associated Diseases & Rule outs
Rule Outs
Acute leukemia
Anemia, aplastic
Sprained neck/Whiplash
Associated Disease & Complications
Acanthocytosis
Anemia
Bone marrow failure/exhaustion
Bone Marrow Fibrosis
Myelodysplasia
Myelofibrosis
Myelofibrosis secondary
Myelosuppression
Pancytopenia
Thrombocytopenia
Anemia in Elderly
Disease Mechanism & Classification
Class
CLASS/Hematologic (category)
CLASS/Leukocyte involvement/disorder (ex)
CLASS/Marrow involvement/disorder (ex)
CLASS/Bone disorder (ex)
CLASS/Skeletal (category)
Pathophysiology
Pathophysiology/Bone marrow infiltration
Pathophysiology/Megakaryopoetic suppression
Pathophysiology/Myelodysplasia process
Process
PROCESS/Complicating disorder (ex)
PROCESS/Inflammatory/Fibrosis
PROCESS/Pre-Leukemic condition (ex)
PROCESS/Reference organ/system (category)
PROCESS/Blood dyscrasia/leukemic process (ex)
Treatment
Drug Therapy - Contraindication
RX/Chlorambucil (Leukeran)
Definition

infiltrative and infectious cause for fibrosis and hypocellular marrow; tbc, kal azar, lymphoma,hairy cell leukemia, gray platelet syndrome, metastatic cancer oat cell carcinoma, myelodysplasia, radiation, chemotherapy ablated doses, myeloid metaplasia

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External Links Related to Myelofibrosis, secondary
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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