Disease Information for Monoclonal gammopathies

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Clinical Manifestations
Signs & Symptoms
Motor and sensory neuropathy/Polyneuropathy signs
Paresthesias
Disease Progression
Course/Chronic disorder
Course/Chronic only
Laboratory Tests
Microbiology & Serology Findings
Serum IGM Specific antibodies abnormally high
Abnormal Lab Findings (Non Measured)
High Sed rate normal CRP level
Lactescent/lipemic serum (Lab)
MGUS serum marker (labs)
Monoclonal M protein spike/electrophoresis (Lab)
URINE Protein Electrophoresis (UPE) abnormal
Abnormal Lab Findings - Increased
Gamma globulin (Lab)
Total Protein, serum (Lab)
Viscosity, serum (Lab)
Associated Diseases & Rule outs
Rule Outs
Multiple myeloma
Waldenstrom's macroglobulinemia
Associated Disease & Complications
Ataxic neuropathy
Chylomicronemia syndrome
Hyperviscosity syndrome
Inflammatory polyneuropathy/demyelinating/chronic
Motor neuron disease
Pyoderma gangrenosa
Hyperviscosity
Disease Mechanism & Classification
Class
CLASS/Hematologic (category)
CLASS/Leukocyte involvement/disorder (ex)
Pathophysiology
Pathophysiology/Dysproteinemia (Ex)
Pathophysiology/Proteins/blood disorder (ex)
Pathophysiology/Immune physiology/defective
Process
PROCESS/Immunoproliferative disease (ex)
PROCESS/Neoplastic (category)
PROCESS/Blood dyscrasia/leukemic process (ex)
PROCESS/Leukemia process (ex).
PROCESS/Monoclonal gammopathy (ex)
PROCESS/Paraproteinemias (ex)
Synonyms
Synonym
Monoclonal gammopathy, Monoclonal gammopathy (morphologic abnormality), Gammapathy Monoclonal, GAMMOPATHY MONOCLONAL, Monoclonal Gammapathies, Monoclonal Gammopathies, Monoclonal Gammopathy, Monoclonal gammopathy (clinical), Monoclonal gammopathy (disorder), Monoclonal gammopathy RETIRED, Synonym/Paraproteinemia (Gammopathy)
Definition

A group of related diseases characterized by an unbalanced or disproportionate proliferation of immunoglobulin-producing cells, usually from a single clone. These cells frequently secrete a structurally homogeneous immunoglobulin (M-component) and/or an abnormal immunoglobulin.

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External Links Related to Monoclonal gammopathies
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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