Disease Information for Metoclopramide (Reglan) Administration/Toxicity

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Clinical Manifestations
Signs & Symptoms
Breast Swelling Bilateral
Galactorrhea/Male
Lactorrhea in a male
Lactorrhea/Galactorrhea/Prolonged lactation
Impotence, relative
Active Bowel Sounds
Borborygmi/Bowel sound increased
Nausea
Vomiting
Cramping in Extremities
Muscle cramps/spasms
Twitchy/muscle spasms
Athetosis
Choreoathetoid movement
Dystonia
Hyperkinetic Movement Disorder
Spasms in Both Legs
Disease Progression
Galactorrhea
Laboratory Tests
Abnormal Lab Findings (Non Measured)
Hyperprolactinemia
Abnormal Lab Findings - Increased
Growth hormone/STH, plasma (Lab)
Prolactin (Lab)
Associated Diseases & Rule outs
Associated Disease & Complications
Cardiac arrhythmias
Drug induced Arrhythmias
Drug Induced Choreoathetosis
Drug induced Impotence.
Drug induced Movement disorder
Drug interaction often
Gynecomastia
Impotence/Erectile dysfunction disorder
Parkinsonism, secondary
Parkinsons disease
Tardive dyskinesia syndrome
Secondary Dystonia
Oculogyric Crisis
Disease Mechanism & Classification
Drugs
DRUG/Antiemetic medication (examples)
DRUG/Chemotherapy emesis blocker (example)
DRUG/Cholinergic agonist drug/effect (example)
DRUG/Cytochrome p450 degradation/pharmacology (ex)
DRUG/Dopamine antagonist (example)
DRUG/Dopamine/depletor central/drug (example)
DRUG/Enteric/gut motor stimulation
DRUG/Metoclopramide-like Prokinetic activity
Pathophysiology
Pathophysiology/Increase TSH synthesis
Rapid Gastric Emptying
Process
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
PROCESS/Hyperkinetic Movement disorders
Synonyms
Synonym
4 Amino 5 chloro N (2 (diethylamino)ethyl) 2 methoxybenzamide, Benzamide 4 amino 5 chloro N (2 (diethylamino)ethyl) 2 methoxy, MCP, Metaclopramide, Metaclopromide, METOCLOPRAMIDE, Metoclopramide (product), Metoclopramide (substance), METOCLOPRAMIDE PREPARATION, Metoclopramide RETIRED, Metoclopramide(motility), Metoclopramide(motility) (see chapter d for preparations), Metoclopramide(motility) (see chapter d for preparations) (product), Metoclopramide(motility) (see chapter d for preparations) (substance), Brand name/Maxeran (Metoclopramide), Brand name/Reglan (Metoclopramide)
Treatment
Drug Dosage
DRUG/Dose 10 mgm (Unit/Pill/Capsule size)
DRUG/Dose 5 mgm (Unit/Pill/Capsule size)
DRUG/Dose QID Medication
DRUG/Generic available
DRUG/Injectable medication (parenteral)
DRUG/Intramuscular injection RX
DRUG/Intravenous administraton RX
DRUG/IV requires lesser dose/Caution
DRUG/Oral medication (ex)
Definition

Prokinetic gut motility drug; Anti-dopaminergic drug used as motility stimulation in Anti-emetic drug; gastroparesis and GERD;may cause tardive dyskinesia and malignant hyperthermia reactions;lowers seizure threshold may cause hypertensive response;avoid in bowel obstruction;oral and parenteral and nasal preparation

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External Links Related to Metoclopramide (Reglan) Administration/Toxicity
Google
Wikipedia
Merck
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PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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