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- Disease Information
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Disease Information for Methemoglobinemia, acquired/toxic
- Clinical Manifestations
- Signs & Symptoms
- Acrocyanosis/Cyanosis extremities
- Blue lips
- Cyanosis
- Venipuncture/Chocolate colored blood/sign
- Nausea
- Vomiting
- Blue Tongue
- Altered mental status Mental status change
- Confusion/agitation on exam
- Confusion/Disoriented
- Dizziness/Dizzy
- Headache
- Irritability/short tempered
- Obtunded/poorly responsive status/signs
- Seizures
- Stupor/poor reponse to stimulus
- Sudden unconsciousness
- Unconscious/Narcosis status
- Cyanosis Child
- Cyanosis Newborn
- Hyperpnea
- Rapid Breathing
- Shortness of breath/SOB
- Sudden onset dyspnea
- Tachypnea/Increased respiratory rate
- Typical Clinical Presentation
- Coma with normal Head CT Scan
- Cyanotic with normal AO2/O2 Sat
- Clinical Presentation & Variations
- Presentation/Collapse Seizure Acidosis Anaerobic
- Disease Progression
- Course/Acute
- Course/Chronic disorder
- Course/Subacute
- Laboratory Tests
- Abnormal Lab Findings (Non Measured)
- Hemoglobin oxygen dissociation curve/abnormal (Lab)
- Abnormal Lab Findings - Increased
- Methemoglobin (Lab)
- URINE Methemoglobin
- Diagnostic Test Results
- X-RAY
- Xray/Basal ganglia calcification/Skull
- Xray/Multiple intracranial calcifications/Head
- Ultrasound
- Ultrasound/Renal/Kidneys echogenic cortex bilateral
- Associated Diseases & Rule outs
- Rule Outs
- Anemia
- Carbon monoxide poisoning
- Hypoxia, systemic
- Associated Disease & Complications
- Angina pectoris
- Cardiac arrhythmias
- Coma/Unconscious
- Convulsions (grand mal)
- Death/Unanticipated
- Methemoglobinemia
- Polycythemia (compensatory)/secondary/anoxia
- Syncope/Fainting
- Disease Mechanism & Classification
- Class
- CLASS/Erythrocyte disorder (ex)
- CLASS/Hematologic (category)
- Pathophysiology
- Pathophysiology/Hemoglobin, high-affinity status
- Pathophysiology/Tissue hypoxia/potential
- Process
- PROCESS/Biochemical (category)
- PROCESS/Metabolic/storage disorder (category)
- PROCESS/Hemoglobinopathy disorder (ex)
- Toxin
- TOXIN/Cellular hypoxia oxidative/hgb release
- Treatment
- Drug Therapy - Indication
- RX/Methylene blue
- Definition
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Oxidant drug or poison causes methemoglobinemia; this changes the dissociation curve so oxygen is tightly bound to hemoglobin now in oxidized state. o2 sat and pulse ox and ao2 reads normal even up to 40% of hgb converted to useless form; methylene blue is the treatment; hereditary recessive disorder existswith absent reductase defect; there is a dominant hereditary hgbM where this is a formed molecule; nitrites, oxidate chemicals; sulfonamides, dapsone, local anesthetics, and pyridium cause this in some;
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- External Links Related to Methemoglobinemia, acquired/toxic
- Wikipedia
- Merck
- Images
- PubMed (National Library of Medicine)
- NGC (National Guideline Clearinghouse)
- Medscape (eMedicine)
- Harrison's Online (accessmedicine)
- NEJM (The New England Journal of Medicine)
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