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Disease Information for Methadone (Dolophine) Administration/Toxicity

Clinical Manifestations

Signs & Symptoms

Breast Swelling Bilateral

Impotence, relative

Individual Patients exquisitly sensitive

Laboratory Tests

Abnormal Lab Findings (Non Measured)

Hyperprolactinemia

Abnormal Lab Findings - Increased

FTI/Free Thyroxin Index (Lab)

Prolactin (Lab)

Thyroid Binding Globulin (Lab)

Thyroxin/T4 (Lab)

Associated Diseases & Rule outs

Associated Disease & Complications

Drug induced Impotence.

Drug induced Interstitial Lung disease.

Gynecomastia

Impotence/Erectile dysfunction disorder

Interstitial lung involvement/manifestation

Opiate/Morphine overdose toxidrome

Disease Mechanism & Classification

Drugs

DRUG/Chronic pain/Neuropathic pain adjunct medication

DRUG/Narcotic/analgesic drug (category)

DRUG/Narcotic/Opiate-opioid medication (example)

DRUG/Safe in pregnancy patient (B)

DRUG/Specialized usage (example)

DRUG/Synthetic opioid agonist (example)

Process

PROCESS/Medication/Drug (CONFIRM dose/before treatment)

Synonyms

Synonym

3 Heptanone 6 (dimethylamino) 4 4 diphenyl, methadone, Methadone (product), Methadone (substance), METHADONE PREPARATION, Brand name/Dolophine (Methadone), Brand name/Methadose (Methadone)

Treatment

Drug Dosage

DRUG/.1990 or before

DRUG/Dose 10 mgm (Unit/Pill/Capsule size)

DRUG/Dose 40 mgm (Unit/Pill/Capsule size)

DRUG/Dose 5 mgm (Unit/Pill/Capsule size)

DRUG/Dose liquid/syrup/suspension form

DRUG/Dose Q6 hrs Medication

DRUG/Dose Q8 Hrs Medication

DRUG/Generic available

DRUG/Oral medication (ex)

Definition

Synthetic opiate narcotic analgesic; less euphoria and long acting drug; useful in chronic pain syndromes and addiction medicine;still respiratory depression especially late; oral preparation

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External Links Related to Methadone (Dolophine) Administration/Toxicity

PubMed (National Library of Medicine)

NGC (National Guideline Clearinghouse)

Medscape (eMedicine)

Harrison's Online (accessmedicine)

NEJM (The New England Journal of Medicine)

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