Disease Information for Meperidine (Demerol) Administration/Toxicity

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Clinical Manifestations
Signs & Symptoms
Excess Sweating Children
Hyperhidrosis/Chronic sweating excess
Excitement
Hand tremors
Irritability/short tempered
Myoclonus/Myoclonic jerks on exam
Nystagmus
Seizures
Tremor
Tremor,fine
Agitation
Psychotic behavior/symptomatic
Queer bizarre behavior/change
Restlessness/Anxiousness
Miosis/narrow pupils
Pupil Abnormal/Signs
True Vertigo Sign Confirmed
Laboratory Tests
Abnormal Lab Findings - Increased
Glucose, blood (Lab)
Associated Diseases & Rule outs
Associated Disease & Complications
Convulsions (grand mal)
Drug induced Seizures
Esophagitis, reflux/GERD
Hyperglycemia
Monoamine oxidase inhibitor toxicity/crisis
Paranoia reaction
Psychosis
Disease Synergy - Causes
Triggers of mastocytosis crises/abdominal pain
Disease Mechanism & Classification
Drugs
DRUG/Active metabolites
DRUG/Analgesic/injectable medication (example)
DRUG/Drug tolerance/effect
DRUG/Important Acute care drugs (example)
DRUG/Mast cell lysis/drug effect
DRUG/Narcotic/analgesic drug (category)
DRUG/Narcotic/Opiate-opioid medication (example)
DRUG/Safe in pregnancy patient (B)
DRUG/Synthetic opioid agonist (example)
DRUG/Tachyphylaxis occurs
DRUG/Toxic metabolites (example)
DRUG/Lowers seizure threshold
Process
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
Synonyms
Synonym
4 Piperidinecarboxylic acid 1 methyl 4 phenyl ethyl ester, Isonipecain, MEPERIDINE, Meperidine (product), Meperidine (substance), MEPERIDINE PREPARATION, Pethidine, Brand name/Demerol (Meperidine)
Treatment
Drug Therapy - Contraindication
RX/Monoamine oxidase inhibitor
Definition

Synthetic narcotic analgesic drug chemically different from opiates; metabolites cause CNS toxicity on prolonged dosing

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External Links Related to Meperidine (Demerol) Administration/Toxicity
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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