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Disease Information for Melphalan (Alkeran) Administration/Toxicity

Clinical Manifestations

Signs & Symptoms

Baldness/Alopecia

Non-scarring Alopecia/balding

Laboratory Tests

Abnormal Lab Findings - Decreased

Lymphocytes (Lab)

Associated Diseases & Rule outs

Associated Disease & Complications

Acute leukemia

Acute Myelocytic/Monocytic Leukemia

Anemia

Anemia, aplastic

Drug induced Anemia.

Drug induced Baldness/Alopecia

Fetal anomaly

Leukemia

Disease Mechanism & Classification

Drugs

DRUG/Alkylating agents (example)

DRUG/Carcinogenic potential

DRUG/Chemotherapeutics/cancer drugs/etc (category)

DRUG/Late leukemia/lymphoma complication

DRUG/Nitrogen mustard alkylating agent

DRUG/Oral Anti-cancer drug (ex)

DRUG/Teratogenic potential/effect (D plus )

Process

PROCESS/Medication/Drug (CONFIRM dose/before treatment)

Synonyms

Synonym

4 (bis(2 chloroethyl)amino) L phenylalanine, 4 (Bis(2 chloroethyl)amino)phenylalanine, Alanine Nitrogen Mustard, L PAM, L Phenylalanine 4 (bis(2 chloroethyl)amino), L Phenylalanine mustard, L sarcolysin, L Sarcolysin Phenylalanine mustard, L Sarcolysine, Melfalan, Melphalan, Melphalan (product), Melphalan (substance), MELPHALAN PREPARATION, Mustard Phenylalanine, p di(chloroethyl)amino L phenylalanine, Phenylalanine Mustard, Phenylalanine Nitrogen Mustard, sarcolysin, Brand name/Alkeran (Melphalan), Brand name/L-PAM (Melphalan), Brand name/Sarcolysin (Melphalan), Synonym/Phenylalanine mustard administration

Treatment

Drug Dosage

DRUG/.1990 or before

DRUG/Dose 2 mgm (Unit/Pill/Capsule size)

DRUG/Dose once daily (RX)

DRUG/Injectable medication (parenteral)

DRUG/Intravenous administraton RX

DRUG/Oral medication (ex)

Definition

Primarily an Antineoplastic cancer chemotherapy drug; Alkylating agents interfere with methylation of DNA in mitosis, inhibits cell division; Speciality use only is recommended; a dangerous class of drugs with predictable bone marrow suppression; oral preparation

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External Links Related to Melphalan (Alkeran) Administration/Toxicity

PubMed (National Library of Medicine)

NGC (National Guideline Clearinghouse)

Medscape (eMedicine)

Harrison's Online (accessmedicine)

NEJM (The New England Journal of Medicine)

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