Disease Information for Melphalan (Alkeran) Administration/Toxicity

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Clinical Manifestations
Signs & Symptoms
Baldness/Alopecia
Non-scarring Alopecia/balding
Laboratory Tests
Abnormal Lab Findings - Decreased
Lymphocytes (Lab)
Associated Diseases & Rule outs
Associated Disease & Complications
Acute leukemia
Acute Myelocytic/Monocytic Leukemia
Anemia
Anemia, aplastic
Drug induced Anemia.
Drug induced Baldness/Alopecia
Fetal anomaly
Leukemia
Disease Mechanism & Classification
Drugs
DRUG/Alkylating agents (example)
DRUG/Carcinogenic potential
DRUG/Chemotherapeutics/cancer drugs/etc (category)
DRUG/Late leukemia/lymphoma complication
DRUG/Nitrogen mustard alkylating agent
DRUG/Oral Anti-cancer drug (ex)
DRUG/Teratogenic potential/effect (D plus )
Process
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
Synonyms
Synonym
4 (bis(2 chloroethyl)amino) L phenylalanine, 4 (Bis(2 chloroethyl)amino)phenylalanine, Alanine Nitrogen Mustard, L PAM, L Phenylalanine 4 (bis(2 chloroethyl)amino), L Phenylalanine mustard, L sarcolysin, L Sarcolysin Phenylalanine mustard, L Sarcolysine, Melfalan, Melphalan, Melphalan (product), Melphalan (substance), MELPHALAN PREPARATION, Mustard Phenylalanine, p di(chloroethyl)amino L phenylalanine, Phenylalanine Mustard, Phenylalanine Nitrogen Mustard, sarcolysin, Brand name/Alkeran (Melphalan), Brand name/L-PAM (Melphalan), Brand name/Sarcolysin (Melphalan), Synonym/Phenylalanine mustard administration
Treatment
Drug Dosage
DRUG/.1990 or before
DRUG/Dose 2 mgm (Unit/Pill/Capsule size)
DRUG/Dose once daily (RX)
DRUG/Injectable medication (parenteral)
DRUG/Intravenous administraton RX
DRUG/Oral medication (ex)
Definition

Primarily an Antineoplastic cancer chemotherapy drug; Alkylating agents interfere with methylation of DNA in mitosis, inhibits cell division; Speciality use only is recommended; a dangerous class of drugs with predictable bone marrow suppression; oral preparation

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External Links Related to Melphalan (Alkeran) Administration/Toxicity
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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