Disease Information for Megaloblastic anemia

Clinical Manifestations
Signs & Symptoms
Anemia symptoms/chronic
Hyporeflexia/DTRs decreased
Chronic Fatigue
Clinical Presentation & Variations
Anemia with Low Reticulocyte Count
Demographics & Risk Factors
Past History
Past history/Anemia
Past history/Gastrectomy
Past history/Sprue/gluten enteropathy
Established Disease Population
Patient/Hypothyroidism (myxedema)
Patient/Malabsorption syndrome
Laboratory Tests
Microbiology & Serology Findings
Abnormal Lab Findings (Non Measured)
Howell Jolly bodies/rbcs (Lab)
Macrocytic anemia (Lab)
Sucrose-water hemolysis test/abnormal (Lab)
Abnormal Lab Findings - Decreased
Hematocrit (Lab)
Hemoglobin (Lab)
RBC/Red Blood Count (Lab)
Reticulocytes (Lab)
Abnormal Lab Findings - Increased
Fetal hemoglobin (Lab)
Lactic Dehydrogenase (LDH LH) (Lab)
MCH (Lab)
MCV/Mean Corpuscular Volume (Lab)
RDW/Red cell size variance (Lab)
Diagnostic Test Results
Bone Marrow/Abnormal
Bone Marrow/Giant metamyelocytes
Bone Marrow/Iron stores normal/anemia
Bone Marrow/Iron stores/increased
Associated Diseases & Rule outs
Associated Disease & Complications
Megaloblastic anemia/disease
Thrombocytopenia in Children
Disease Mechanism & Classification
CLASS/Erythrocyte disorder (ex)
CLASS/Hematologic (category)
Pathophysiology/Ineffective erythropoesis
Pathophysiology/Myelodysplasia process
PROCESS/Pathophysiology/organ-system (category)
PROCESS/Reference organ/system (category)

anemias associated with impaired DNA synthesis in bone marrow progenitor cells leading to odd shaped, macrocytic, or dysfunctional erythrocytes; usually caused by B12 or folate deficiency;--------------------------------

Synonyms of Anemia, Megaloblastic; Folate Deficiency Anemia

Folic Acid Deficiency Anemia; Hypovitaminosis B12;

Megaloblastic Anemia of Pregnancy; Vitamin B12 Deficiency Anemia; An anemia is a condition in which the number of red blood cells (RBC) or the amount of hemoglobin (the protein in red blood cells that carries oxygen throughout the body) is below normal; Megaloblastic Anemias (MGA) are rare blood disorders characterized by the presence of large, structurally and visually abnormal, immature red blood cells (megaloblasts); Decreased numbers and immaturity of white blood cells (leukocytes) and blood platelets (thrombocytes) may also occur; Megaloblastic Anemias are usually caused by a deficiency or defective absorption of either vitamin B12 (cobalamin) or folic acid; As a result, they are also known as the vitamin deficiency anemias; In most cases, the fundamental flaws leading to the several forms of MGA caused by vitamin deficiencies are present at the time of birth and exist as a result of a genetic defect; In addition, certain antitumor or immunosuppressive drugs may also cause Megaloblastic Anemia -------[NORD 2005]-------------


External Links Related to Megaloblastic anemia
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)