Disease Information for Megaloblastic anemia

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Clinical Manifestations
Signs & Symptoms
Anemia symptoms/chronic
Hyporeflexia/DTRs decreased
Chronic Fatigue
Pallor
Clinical Presentation & Variations
Anemia with Low Reticulocyte Count
Demographics & Risk Factors
Past History
Past history/Anemia
Past history/Gastrectomy
Past history/Sprue/gluten enteropathy
Established Disease Population
Patient/Hypothyroidism (myxedema)
Patient/Malabsorption syndrome
Laboratory Tests
Microbiology & Serology Findings
Reticulocytosis
Abnormal Lab Findings (Non Measured)
Howell Jolly bodies/rbcs (Lab)
Macrocytic anemia (Lab)
Sucrose-water hemolysis test/abnormal (Lab)
Abnormal Lab Findings - Decreased
Hematocrit (Lab)
Hemoglobin (Lab)
RBC/Red Blood Count (Lab)
Reticulocytes (Lab)
Abnormal Lab Findings - Increased
Fetal hemoglobin (Lab)
Lactic Dehydrogenase (LDH LH) (Lab)
MCH (Lab)
MCV/Mean Corpuscular Volume (Lab)
RDW/Red cell size variance (Lab)
Diagnostic Test Results
Pathology
Bone Marrow/Abnormal
Bone Marrow/Giant metamyelocytes
Bone Marrow/Iron stores normal/anemia
Bone Marrow/Iron stores/increased
Associated Diseases & Rule outs
Associated Disease & Complications
Anemia
Megaloblastic anemia/disease
Thrombocytopenia
Thrombocytopenia in Children
Disease Mechanism & Classification
Class
CLASS/Erythrocyte disorder (ex)
CLASS/Hematologic (category)
Pathophysiology
Pathophysiology/Ineffective erythropoesis
Pathophysiology/Myelodysplasia process
Process
PROCESS/Pathophysiology/organ-system (category)
PROCESS/Reference organ/system (category)
Definition

anemias associated with impaired DNA synthesis in bone marrow progenitor cells leading to odd shaped, macrocytic, or dysfunctional erythrocytes; usually caused by B12 or folate deficiency;--------------------------------

Synonyms of Anemia, Megaloblastic; Folate Deficiency Anemia

Folic Acid Deficiency Anemia; Hypovitaminosis B12;

Megaloblastic Anemia of Pregnancy; Vitamin B12 Deficiency Anemia; An anemia is a condition in which the number of red blood cells (RBC) or the amount of hemoglobin (the protein in red blood cells that carries oxygen throughout the body) is below normal; Megaloblastic Anemias (MGA) are rare blood disorders characterized by the presence of large, structurally and visually abnormal, immature red blood cells (megaloblasts); Decreased numbers and immaturity of white blood cells (leukocytes) and blood platelets (thrombocytes) may also occur; Megaloblastic Anemias are usually caused by a deficiency or defective absorption of either vitamin B12 (cobalamin) or folic acid; As a result, they are also known as the vitamin deficiency anemias; In most cases, the fundamental flaws leading to the several forms of MGA caused by vitamin deficiencies are present at the time of birth and exist as a result of a genetic defect; In addition, certain antitumor or immunosuppressive drugs may also cause Megaloblastic Anemia -------[NORD 2005]-------------

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External Links Related to Megaloblastic anemia
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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