Disease Information for Mefloquine (Lariam) Administration/Toxicity

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Clinical Manifestations
Signs & Symptoms
Slow pulse/Bradycardia
Abdominal Pain
Abdominal Pain Crampy
Gastrointestinal side effects/secondary
Nightmares/excess dreaming (Paroniria)
Seizures
Hallucination/visual
Diagnostic Test Results
EKG (ECG)
EKG/Prolonged QRS interval (ECG)
EKG/Widened QRS pattern (ECG)
EKG/Drug induced QT prolongation (ECG)
EKG/Prolonged QT interval (ECG)
EKG/AV Nodal Block/Complete
EKG/Sinus bradycardia (ECG)
EKG/Changes/abnormalities (ECG)
Associated Diseases & Rule outs
Associated Disease & Complications
Acute brain syndrome
Bradyarrhythmias
Cardiac arrhythmias
Cardiac conduction defects
CNS side effects
Convulsions (grand mal)
Drug induced Arrhythmias
Drug induced Dreaming/nightmares (Paroniria)
Drug induced Prolonged Q-T interval
Drug induced Seizures
Heart block, complete
Heart block, first degree
Sinus bradycardia
Ventricular fibrillation
Ventricular tachycardia/arrest
Disease Mechanism & Classification
Drugs
DRUG/Antimalarial medications (examples)
DRUG/Anti-parasitic medications (examples)
DRUG/Quinidine-like myocardial effect
DRUG/Quinine derivative/congener (example)
DRUG/Lowers seizure threshold
Process
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
Synonyms
Synonym
4 Quinolinemethanol alpha 2 piperidinyl 2 8 bis(trifluoromethyl) (R* S*) (+ ), Mefloquine, Mefloquine (product), Mefloquine (substance), MEFLOQUINE PREPARATION, Mefloquine product, Mephloquine, Brand name/Lariacun (Mefloquin), Brand name/Lariam (Mefloquin)
Treatment
Drug Therapy - Contraindication
RX/Beta-blocker
RX/Calcium-channel blocker
RX/Chloroquin (Aralen)
RX/Diltiazem (Cardizem)
RX/Quinidine (Quinaglute)
RX/Quinine (generic)
RX/Verapamil (Calan)
Drug Dosage
DRUG/Dose 250 mgm (Unit/Pill/Capsule size)
DRUG/Dose single dose medication
DRUG/Dose Weekly
DRUG/Given prophylactically
DRUG/Half life 13-24 days
DRUG/Half-life very long (days)
DRUG/Oral medication (ex)
-Protein bound/drug
Definition

Anti-malaria antibiotic drug; oral preparation; can cause conduction delay and heart block; avoid usage with beta blocker drugs and certain others (Cardizem and Calan)

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External Links Related to Mefloquine (Lariam) Administration/Toxicity
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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