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Disease Information for Mefloquine (Lariam) Administration/Toxicity

Clinical Manifestations

Signs & Symptoms

Slow pulse/Bradycardia

Abdominal Pain

Abdominal Pain Crampy

Gastrointestinal side effects/secondary

Nightmares/excess dreaming (Paroniria)

Seizures

Hallucination/visual

Diagnostic Test Results

EKG (ECG)

EKG/Prolonged QRS interval (ECG)

EKG/Widened QRS pattern (ECG)

EKG/Drug induced QT prolongation (ECG)

EKG/Prolonged QT interval (ECG)

EKG/AV Nodal Block/Complete

EKG/Sinus bradycardia (ECG)

EKG/Changes/abnormalities (ECG)

Associated Diseases & Rule outs

Associated Disease & Complications

Acute brain syndrome

Bradyarrhythmias

Cardiac arrhythmias

Cardiac conduction defects

CNS side effects

Convulsions (grand mal)

Drug induced Arrhythmias

Drug induced Dreaming/nightmares (Paroniria)

Drug induced Prolonged Q-T interval

Drug induced Seizures

Heart block, complete

Heart block, first degree

Sinus bradycardia

Ventricular fibrillation

Ventricular tachycardia/arrest

Disease Mechanism & Classification

Drugs

DRUG/Antimalarial medications (examples)

DRUG/Anti-parasitic medications (examples)

DRUG/Quinidine-like myocardial effect

DRUG/Quinine derivative/congener (example)

DRUG/Lowers seizure threshold

Process

PROCESS/Medication/Drug (CONFIRM dose/before treatment)

Synonyms

Synonym

4 Quinolinemethanol alpha 2 piperidinyl 2 8 bis(trifluoromethyl) (R* S*) (+ ), Mefloquine, Mefloquine (product), Mefloquine (substance), MEFLOQUINE PREPARATION, Mefloquine product, Mephloquine, Brand name/Lariacun (Mefloquin), Brand name/Lariam (Mefloquin)

Treatment

Drug Therapy - Contraindication

RX/Beta-blocker

RX/Calcium-channel blocker

RX/Chloroquin (Aralen)

RX/Diltiazem (Cardizem)

RX/Quinidine (Quinaglute)

RX/Quinine (generic)

RX/Verapamil (Calan)

Drug Dosage

DRUG/Dose 250 mgm (Unit/Pill/Capsule size)

DRUG/Dose single dose medication

DRUG/Dose Weekly

DRUG/Given prophylactically

DRUG/Half life 13-24 days

DRUG/Half-life very long (days)

DRUG/Oral medication (ex)

-Protein bound/drug

Definition

Anti-malaria antibiotic drug; oral preparation; can cause conduction delay and heart block; avoid usage with beta blocker drugs and certain others (Cardizem and Calan)

(Edit)

External Links Related to Mefloquine (Lariam) Administration/Toxicity

PubMed (National Library of Medicine)

NGC (National Guideline Clearinghouse)

Medscape (eMedicine)

Harrison's Online (accessmedicine)

NEJM (The New England Journal of Medicine)

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