Disease Information for Medulloblastoma

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Clinical Manifestations
Signs & Symptoms
Hiccough/Hiccups
Vomiting in Children
Tongue fasciculations
Altered mental status Mental status change
Babinski's upgoing toes/bilateral
Cerebellar signs
Coma/infant or newborn
Dysdiadochokinesia/Alternating failure
Headache
Headache in children
Obtunded/poorly responsive status/signs
Sudden unconsciousness
Unconscious/Narcosis status
Disease Progression
Course/Chronic disorder
Course/Chronic only
Demographics & Risk Factors
Population Group
Child
Population/Pediatrics population
Sex & Age Groups
Population/Child
Population/Child-Infant Only
Population/Children/all
Diagnostic Test Results
Other Tests & Procedures
Lumbar puncture/Increased CSF pressure/LP test
CT Scan
CT Scan/Head brain stem lesion
CT Scan/Head Large third ventricle
CT Scan/Mass in 4th ventrical/Head
MRI/Head Scan Abnormal
MRI/Head scan Brain stem lesion
PET Scan/Head FDDNP abnormal
X-RAY
Xray/Osteoblastic metastasis/Skeletal
Associated Diseases & Rule outs
Associated Disease & Complications
Brain stem lesion
Coma in Children
Coma/Unconscious
DROP Metastasis
Medulloblastoma
Paralysis/soft palate
Sleep apnea/central type
Intracranial Lesion
Disease Mechanism & Classification
Class
CLASS/Pediatric disorders (ex)
CLASS/Brain/CNS disorder (ex)
CLASS/Neurologic (category)
Pathophysiology
Pathophysiology/Gene locus 9q31
Pathophysiology/Gene locus Chromosome 9
Pathophysiology/Gene locus Chromosome 9q
Pathophysiology/KIT gene [Tyrosinase oncogene)
Pathophysiology/Obstruction fourth ventricle/CNS
Pathophysiology/CNS mass lesion effect
Pathophysiology/CSF Pressure Increased
Process
PROCESS/Malignancy in childhood (ex)
PROCESS/Neoplastic (category)
PROCESS/Primary intracranial tumor (ex)
Treatment
Drug Therapy - Indication
RX/Chemotherapy(cancer)
Other Treatments
TX/Brain radiation.
TX/Radiotherapy.
Definition

A malignant brain tumor that begins in the lower part of the brain and can spread to the spine or to other parts of the body; Medulloblastomas are sometimes called primitive neuroectodermal tumors (PNET);

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Medulloblastoma; Medulloblastoma is a cancerous (malignant) tumor of the lower part of the brain (infratentorial [posterior fossa] tumor) that is derived from immature nerve cells known as neuroblasts (ie, primitive neuroectodermal tumor [PNET]); It is considered the most common malignant brain tumor in children yet is extremely rare in adults; Medulloblastomas generally arise in the back (posterior), mid region (ie, vermis) of the cerebellum, which is the part of the brain behind the brain stem involved in coordinating voluntary movements and regulating balance and posture; They typically infiltrate the roof or side wall of the fluid-filled fourth cavity (ventricle) of the brain, extending into the cavity; (There are four ventricles within the brain that are filled with cerebrospinal fluid [CSF] and joined by ducts, through which the fluid circulates); Medulloblastomas may invade the protective membranes (meninges) surrounding the brain and spread (metastasize) via the CSF to the spinal cord, to the surface of the hemispheres of the brain (cerebrum), and, less commonly, to sites outside the brain and spinal cord (ie, central nervous system), particularly to bone; ----------[NORD]-----------

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External Links Related to Medulloblastoma
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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