Disease Information for Mantle Cell Lymphoma/variant

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Clinical Manifestations
Signs & Symptoms
Unilateral cervical adenopathy
Night sweats
Abdominal Distension
Abdominal Mass
Epigastric mass
Cervical adenopathy
Lymphadenopathy Systemic
Matted/regional adenopathy/firm
Supraclavicular adenopathy
Hepatosplenomegaly
Splenomegaly
Chronically ill patient/signs
Fatigue
Fever
Weakness
Weight Loss
Disease Progression
Course/Median survival 3-4 years
Course/Prognosis bad/usually
Course/Relapsing
Demographics & Risk Factors
Population Group
Middle Age Adult
Sex & Age Groups
Population/Elderly Aged
Population/Male
Population/Sixties-adult
Laboratory Tests
Abnormal Lab Findings (Non Measured)
Flow cytometry tests/abnormal (Lab)
Abnormal Lab Findings - Increased
Beta2-microglobulin, serum (Lab)
Diagnostic Test Results
Other Tests & Procedures
Colonoscopy/Abnormal
Pathology
BX/Bone Marrow Biopsy/Abnormal
Cells Immunophenotyping abnormal
CT Scan
CT Scan/CTA Abdomen Abnormal
CT Scan/Chest abnormal
PET Scan/Chest abnormal
Associated Diseases & Rule outs
Rule Outs
Hodgkin's disease
Lymphoma of colon
Lymphoma/Malignant lymphoma
Associated Disease & Complications
Anemia
Intestinal/gut lymphoma
Lymphoma/Malignant lymphoma
Lymphoproliferative disorder
Disease Mechanism & Classification
Class
CLASS/Hematologic (category)
Pathophysiology
Pathophysiology/Chromosomal translocation
Pathophysiology/Gene locus Chromosome 11
Pathophysiology/Gene locus chromosome 14
Pathophysiology/Variable course subsets/severe/mild
PROCESS/B-Cell Lymphoma
Pathophysiology/Apoptosis/cell death deregulation/genetic
Pathophysiology/Somatic mutation Tumor Tissue
Process
PROCESS/INCIDENCE/Rare disease (ex)
PROCESS/Lymphomas (ex)
PROCESS/Neoplastic (category)
Treatment
Drug Therapy - Indication
RX/Chemotherapy combination/protocol
RX/CHOP Chemo Protocol
RX/Rituximab (Retuxan)
Definition

Mantle cell lymphoma (MCL); A Non-Hodgkin"s lymphoma (NHLs) ; Mantle cell lymphoma (MCL) is a B-cell lymphoma that develops from malignant B-lymphocytes within a region of the lymph node known as the mantle zone; NHLs may also be categorized based upon certain characteristics of the cancer cells as seen under a microscope and how quickly they may tend to grow and spread; For example, NHLs may be characterized as "low-grade" (or indolent) lymphomas, which tend to grow slowly and result in few associated symptoms, or "intermediate-" or "high-grade" (aggressive) lymphomas, which typically grow rapidly, requiring prompt treatment; There is some debate concerning whether MCL should be categorized as a slow-growing (indolent) or rapidly-growing (aggressive) lymphoma; Although experts have classified MCL as an aggressive lymphoma, it has been shown to have certain characteristics of indolent lymphoma; According to various estimates, MCL represents approximately 2 to 7 percent of adult NHLs in the United States and Europe; It primarily affects men over the age of 50 years; Many affected individuals have widespread disease at diagnosis, with involved regions often including multiple lymph nodes, the spleen, and, potentially, the bone marrow, the liver, and/or regions of the digestive (gastrointestinal) tract; ---------------[NORD]--------------

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External Links Related to Mantle Cell Lymphoma/variant
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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