Disease Information for Macroglobulinemias

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Clinical Manifestations
Signs & Symptoms
Bruising/Ecchymosis
Pruritis Itching
Anemia symptoms/chronic
Excessive/easy bruising tendency
Motor and sensory neuropathy/Polyneuropathy signs
Paresthesias
Epistaxis, severe/persistent
Retinal veins tortuous/distended
Acute Hearing Loss
Clinical Presentation & Variations
Presentation/Progressive Motor Sensory Polyneuropathy
Fever and High Sed Rate
Disease Progression
Course/Chronic only
Laboratory Tests
Abnormal Lab Findings (Non Measured)
Bleeding time prolonged/platelet count normal (Lab)
Lactescent/lipemic serum (Lab)
Monoclonal M protein spike/electrophoresis (Lab)
Rouleaux RBC pattern/blood smear (Lab)
Very High Sed Rate
Abnormal Lab Findings - Decreased
Anion gap (Lab)
Beta globulin, serum (Lab)
Hematocrit (Lab)
Hemoglobin (Lab)
Abnormal Lab Findings - Increased
Beta globulin, serum (Lab)
Gamma globulin (Lab)
Globulin, serum (Lab)
Hematocrit (Lab)
IGG/Immunoglobulin G (Lab)
IGM/Immunoglobulin M (Lab)
Rouleaux formation (Lab)
Sed Rate/ESR/Sedimentation rate (Lab)
URINE Bence Jones protein
URINE Protein (Albumin)
Diagnostic Test Results
X-RAY With contrast
IVP/Dense nephrogram, bilateral
Associated Diseases & Rule outs
Rule Outs
Multiple myeloma
Associated Disease & Complications
Amyloidosis, secondary
Amyloidosis, systemic
Anemia
Cerebral thrombosis
Cold autoimmune hemolytic anemia
Hyperglobulinemia
Hyperviscosity syndrome
Livedo reticularis
Macroglobulinemia
Osteomalacia
Peripheral neuropathy
Polyneuritis
Proteinuria
Raynaud's syndrome
Renal tubular acidosis, distal
Renal tubule acidosis, acquired
Retinal vein thrombosis, central
Type V hyperlipidemia
Leg ulcers
Hypercoaguability
Polyneuropathy
Proteinuria in Children
Disease Mechanism & Classification
Class
CLASS/Hematologic (category)
CLASS/Leukocyte involvement/disorder (ex)
Pathophysiology
Pathophysiology/Dysproteinemia (Ex)
Pathophysiology/Proteins/blood disorder (ex)
Pathophysiology/Renal intratubular obstruction process
Process
PROCESS/Biochemical (category)
PROCESS/Chemotherapy responsive cancer (ex)
PROCESS/Immunoproliferative disease (ex)
PROCESS/Neoplastic (category)
PROCESS/Blood dyscrasia/leukemic process (ex)
PROCESS/Leukemia process (ex).
PROCESS/Monoclonal gammopathy (ex)
Treatment
Drug Therapy - Indication
SX/Stem cell transplant/autologous
SX/Stem-cell transplant
Definition

A rare cancer of the lymph cells that causes the body to produce abnormal levels of plasma cells (plasmacytosis) and lymphocytes (lymphocytosis) in the bone marrow. Waldenstrom's macroglobulinemia may also cause a decrease in red blood cells (anemia) and enlargement of the liver (hepatomegaly), spleen (splenomegaly), or glands (adenopathy).

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External Links Related to Macroglobulinemias
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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