Disease Information for Lynch Family Cancer syndrome (HNPCC)

Demographics & Risk Factors
Family History
Family history/Breast cancer
Family history/Colon carcinoma
Family history/Endometrial cancer
Family history/Ovarian cancer
Family history/Renal cancer
Associated Diseases & Rule outs
Associated Disease & Complications
Adenocarcinoma gastric
Adenocarcinoma, breast
Adenocarcinoma, colon
Adenocarcinoma, ovary
Adenocarcinoma, uterus
Brain tumor
Carcinoma of duodenum
Carcinoma, bladder, transitional
Carcinoma, rectum
Carcinoma, renal cell
Carcinoma, small bowel
Carcinoma, ureter
Lynch Familial Cancer Syndrome
Disease Mechanism & Classification
CLASS/Pediatric disorders (ex)
Pathophysiology/Gene locus 18q11-q12
Pathophysiology/Gene locus Chromosome 18
Pathophysiology/Gene locus Chromosome 18q
Pathophysiology/Gene Locus Identified/OMIM database
Pathophysiology/Genomic indentifiers (polymorphism/snip/mutations)
Pathophysiology/Hereditary Cancer
Pathophysiology/Maternal Chromosome mutation
Pathophysiology/Chromosome Multiple DNA Micro-Satellites
Pathophysiology/HNPCC Gene Mutation
Pathophysiology/LCF2 Gene Mutation
Pathophysiology/Mismatched DNA Repair Genes
PROCESS/Autosomal dominant hereditary disease (ex).
PROCESS/Eponymic (category)
PROCESS/Eponymic/Esoteric/Not yet integrated into database
PROCESS/Genetic disorder/Spontaneous mutations/sporadic
PROCESS/Hereditofamilial (category)
PROCESS/INCIDENCE/Esoteric disease (example)
Lynch family cancer syndrome LCF2 (18q11 q12), Syn/HNPCC Syndrome, Syn/HNPColorectal Cancer, Synonym/Hereditary non-polyposis Colorectal carcinoma/variant, Synonym/Lynch's syn (Hereditary Colorectal ca) variant

Right-sided predominance. Predominantly early-onset proximal colon carcinomas.

Familial predisposition for other primary cancers in addition to the predisposition for colon cancer; site is often female reproductive organs. Predominantly early onset proximal colon carcinoma associated with other extracolonic adenocarcinomas, particularly endometrial carcinoma. autosomal dominant traits.

The Lynch Syndromes are rare hereditary disorders that usually cause cancer to develop either in the colorectal area or in other sites. Primary cancers may develop in the female genital tract, stomach, brain, breasts, or urological system. The cancers of the colorectal area associated with the Lynch Syndromes usually develop at a younger age than is normally found in other persons with colorectal cancer.[nord 2005]------


External Links Related to Lynch Family Cancer syndrome (HNPCC)
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)