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Disease Information for Lynch Family Cancer syndrome (HNPCC)
- Demographics & Risk Factors
- Family History
- Family history/Breast cancer
- Family history/Colon carcinoma
- Family history/Endometrial cancer
- Family history/Ovarian cancer
- Family history/Renal cancer
- Associated Diseases & Rule outs
- Associated Disease & Complications
- Adenocarcinoma gastric
- Adenocarcinoma, breast
- Adenocarcinoma, colon
- Adenocarcinoma, ovary
- Adenocarcinoma, uterus
- Brain tumor
- Carcinoma of duodenum
- Carcinoma, bladder, transitional
- Carcinoma, rectum
- Carcinoma, renal cell
- Carcinoma, small bowel
- Carcinoma, ureter
- Glioblastoma/CNS
- Lynch Familial Cancer Syndrome
- Disease Mechanism & Classification
- Class
- CLASS/Pediatric disorders (ex)
- Pathophysiology
- Pathophysiology/Gene locus 18q11-q12
- Pathophysiology/Gene locus Chromosome 18
- Pathophysiology/Gene locus Chromosome 18q
- Pathophysiology/Gene Locus Identified/OMIM database
- Pathophysiology/Genomic indentifiers (polymorphism/snip/mutations)
- Pathophysiology/Hereditary Cancer
- Pathophysiology/Maternal Chromosome mutation
- Pathophysiology/Chromosome Multiple DNA Micro-Satellites
- Pathophysiology/HNPCC Gene Mutation
- Pathophysiology/LCF2 Gene Mutation
- Pathophysiology/Mismatched DNA Repair Genes
- Process
- PROCESS/Autosomal dominant hereditary disease (ex).
- PROCESS/Eponymic (category)
- PROCESS/Eponymic/Esoteric/Not yet integrated into database
- PROCESS/Genetic disorder/Spontaneous mutations/sporadic
- PROCESS/Hereditofamilial (category)
- PROCESS/INCIDENCE/Esoteric disease (example)
- Synonyms
- Synonym
- Lynch family cancer syndrome LCF2 (18q11 q12), Syn/HNPCC Syndrome, Syn/HNPColorectal Cancer, Synonym/Hereditary non-polyposis Colorectal carcinoma/variant, Synonym/Lynch's syn (Hereditary Colorectal ca) variant
- Definition
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Right-sided predominance. Predominantly early-onset proximal colon carcinomas.
Familial predisposition for other primary cancers in addition to the predisposition for colon cancer; site is often female reproductive organs. Predominantly early onset proximal colon carcinoma associated with other extracolonic adenocarcinomas, particularly endometrial carcinoma. autosomal dominant traits.
The Lynch Syndromes are rare hereditary disorders that usually cause cancer to develop either in the colorectal area or in other sites. Primary cancers may develop in the female genital tract, stomach, brain, breasts, or urological system. The cancers of the colorectal area associated with the Lynch Syndromes usually develop at a younger age than is normally found in other persons with colorectal cancer.[nord 2005]------
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- External Links Related to Lynch Family Cancer syndrome (HNPCC)
- Wikipedia
- Merck
- Images
- PubMed (National Library of Medicine)
- NGC (National Guideline Clearinghouse)
- Medscape (eMedicine)
- Harrison's Online (accessmedicine)
- NEJM (The New England Journal of Medicine)
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