Disease Information for Lupus erythematosis, systemic
Synonyms:
Disseminated lupus erythematos, DISSEMINATED LUPUS ERYTHEMATOSUS, erythematosus lupus systemic, LE SYNDROME, LE systemic, lupus, LUPUS ERYTHEMATOSIS, LUPUS ERYTHEMATOSIS DISSEMINATED, LUPUS ERYTHEMATOSUS DISSEMINATED, Lupus Erythematosus Disseminatus, LUPUS ERYTHEMATOSUS SYSTEMIC, Lupus syndrome, SLE, SLE Lupus Erythematosus Systemic, SLE Systemic lupus erythematosus, SLE System lupus erythematosus, SYNDROME DISSEMINATED LUPUS ERYTHEMATOSIS, Syndrome lupus, system lupus erythematosus, Systemic lupus erythematos, SYSTEMIC LUPUS ERYTHEMATOSIS, Systemic lupus erythematosus, Systemic lupus erythematosus (disorder), SYSTEMIC LUPUS ERYTHEMATOSUS SYND, Systemic lupus erythematosus unspecified
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Disseminated lupus erythematos, DISSEMINATED LUPUS ERYTHEMATOSUS, erythemat... (more)
Definition:
chronic inflammatory connective tissue condition, autoimmune processes involving many tissues;effects young women usually but also children and males; skin, joints, serous surfaces (pleurisy, pericarditis, peritoneum), and kidney are usual targets; also more severe vasculitis occurs; usually low WBC and platelets and often hemolytic anemia occur as well as cerebral and behavior effects; best lab test is anti-double stranded DNA antibodies.
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chronic inflammatory connective tissue condition, autoimmune processes invo... (more) (edit)
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Demographics & Risk Factors[next]
- Ethnic or Racial Factors
- Recent Event
- Established Disease Population
- Population Group
- Population/Immigrant population
- Young Asian Women Population
- Occupational Factors
- Family History
- Sex & Age Groups
- Population/Adult ('twenties')
- Population/Adult/all
- Population/Female
- Population/Middle-aged adult
- Population/Woman patient
- Population/Young adult
Clinical Manifestations[previous][top][next]
- Typical Clinical Presentation
- Acute polyarthritis syndrome/Days
- Arthritis Syndrome with Eye Lesions
- Arthritis with Subcutaneous/Skin Nodules
- Males sicker than females/characteristic
- Presentation/ Papular rash face upper arms
- Presentation/Fever with arthritis signs
- Presentation/Glomerulonephritis/rapid progressive
- Presentation/Hypertension/abrupt onset
- Presentation/Pleural effusions/recurrent
- Presentation/Recurrent aseptic meningitis
- Presentation/Recurrent pericarditis
- Single Joint Arthritis
- Disease Progression
- Course/Chronic disorder
- Course/Chronic only
- Signs & Symptoms
- Fever Non Infection
- Middle Age Adult
- Woman
- Young Adult
- Facial Malar flush/rash
- Lupus-like butterfly rash,face
- Plethora/Red face/Ruddy look
- Rash/nasal area
- Sun exposed areas/face, arms/involved
- Acute Chest Pain in Children
- Diastolic hypertension
- Nailfold capillary/giant loops sign
- Osler's nodules/finger-tips/Osler's nodes
- Red/erythema skin discoloration
- Annular lesions rash
- Baldness/Alopecia
- Bruising/Ecchymosis
- Cheek/facial skin distribution
- Cicatrical alopecia
- Depigmented patches, skin
- Discoid rash
- Erythroderma
- Face skin lesions
- Facial erythema
- Facial flushing/Beet red
- Facial rash
- Facial rash sparing nasolacrimal folds
- Fever and Rash
- Fingernails Telangiectasias
- Hypopigmentation
- Janeway lesions (palms/soles)
- Koilonychia/Spoon nails
- Leg Ulcers in Elderly
- Mucocutaneous rash/signs
- Nailfold infarcts
- Non-pruritic rash
- Non-scarring Alopecia/balding
- Papulosquamous rash
- Periungual redness
- Photosensitivity/Sunsensitive skin
- Plaques/cutaneous
- Porcelain red-ringed atrophic spots
- Pruritis/Itching
- Rash
- Rash face/exposed areas/arms/neck
- Rash hand/foot areas
- Rash/polycyclic/multidiscoid
- Skin lesions
- Splinter hemorrhage/nailbed
- Subepidermal Blisters
- White skin discoloration
- Oral-genital ulcers
- Penis Rash
- Penis ulcer/lesion
- Excessive/easy bruising tendency
- Abdominal Pain
- Anorexia in Children
- Anorexia in Elderly
- Anorexia/Decreased appetite
- Nausea
- Vomiting
- Weight loss in Elderly
- Oral erythematous lesion
- Oral lesion/ulcer
- Oral Ulcers in Children
- Oral Ulcers in Elderly
- Oral Vesicles
- Painless oral ulcers
- Parotid swelling
- Ulcerative stomatitis
- Lymphadenopathy
- Lymphadenopathy, systemic
- Hepatomegaly
- Hepatosplenomegaly
- Palpable Liver
- Muscle weakness
- Behavior problems
- Confusion/agitation on exam
- Confusion/Disoriented
- Cranial nerve abnormalities/involvement/signs
- Glove/stocking hypesthesia
- Headache
- Nasal speech/regurgitation
- Paresthesias
- Seizures
- Dyspnea
- Hemoptysis
- Pleural Friction Rub.
- Pleuritic chest pain
- Shortness of breath/SOB
- Depressed/discouraged/sad
- Psychiatric manifestations/problems/difficulties
- Arthralgias
- Arthritis and Heart murmur
- Arthritis and weight loss
- Arthritis fever and rash presentation
- Arthritis with Abdominal Pain
- Arthritis with Muscle Weakness
- Arthritis with rash/dermatitis
- Asymmetric arthritis/multiple joints
- Distal interphalageal joint arthritis
- Joint effusion
- Joint exam/signs
- Joint inflammation signs
- Joint Pains
- Joint pains/Arthralgias in Children
- Joint pains/Arthralgias in Elderly
- Joint Swelling
- Limp
- Limping gait/orthopedic/antalgic
- Monoarticular Arthritis/One joint acute
- Multiple Joint Arthritis
- Oligoarthritis syndrome/signs
- Polyarticular Joint Pain
- Symmetrical arthritis (signs)
- Nasal congestion
- Nasal/Hyponasal sound to voice
- Nasopharyngeal ulcerations
- Parotid Gland Enlargement
- Hematuria
- Splenomegaly
- Chronically ill patient/signs
- Enervated/extreme acute fatigue
- Episodic symptoms/events
- Fatigue/chronic
- Fatigue/tiredness/exhaustion
- Fever
- Fever and Normal Sed Rate
- Fever of unknown origin/chronic fever
- Fever Remittant/Recurrent
- Fever with High sed Rate
- Fever, intermittant/recurrent
- Fever/Febrile Possible
- Flu-Like Syndrome
- Good days/Bad days/'Blahs' feelings
- High body temperature
- Malaise
- Multiple organ/system failure patient
- Multisystem disease/signs
- Pallor
- Total body pain/truncal/extremities
- Weight loss
- Bloodshot eyes/Conjunctival injection
- Eye Pains, Bilateral
- Lacrimal gland enlarged
- Periorbital/ocular rash
- Red Eyes Bilateral
- Scleral Injection
- Visual symptoms
- Typical Clinical Presentation
Laboratory Tests[previous][top][next]
- Microbiology & Serology Findings
- Abnormal Lab Findings (Non Measured)
- PLEURAL Exudate
- Acute inflammatory markers elevated (Lab)
- Anaphylatoxin C3a/des Arg present (Lab)
- Bleeding time prolonged/platelet count normal (Lab)
- Chronic lymphopenia
- Left shifted differential smear (Lab)
- Leukopenia
- Low WBC/Left shift/Low platelets (Lab)
- Lupus anticoagulant/level/present (Lab)
- Lymphopenia
- Normocytic Anemia/High Retic count
- Normocytic anemia/low retic count
- PFA100 (Platelet Function Assay/?) abnormal
- PTT increased normal PT (Lab)
- URINE Dipstick /Blood abnormal
- URINE Sediment/Urinalysis abnormal
- Class II HLA (Lab)
- HLA B8 (Lab)
- HLA DR2 (Lab)
- HLA DR3 (Lab)
- HLA DR4 (Lab)
- HLA DRw3 (Lab)
- HLA Specific association (Lab)
- Abnormal Lab Findings - Decreased
- Antithrombin III (Lab)
- WBC
- Albumin, serum (Lab)
- C1-esterase inhibitor titer (Lab)
- C3, serum (Lab)
- Complement (total CH50) level (Lab)
- Haptoglobin, serum (Lab)
- Hematocrit (Lab)
- Hemoglobin (Lab)
- Leukocyte Alkaline phosphatase (Lab)
- Lymphocytes (Lab)
- Neutrophiles (Lab)
- Platelet count (Lab)
- RBC/Red Blood Count (Lab)
- Transferrin saturation (Lab)
- WBC/White Blood Cell Count/Leukocytes (Lab)
- CSF Complement
- SYNOVIAL C3(Complement)
- SYNOVIAL C4(Complement)
- SYNOVIAL Complement
- SYNOVIAL Glucose
- PLEURAL Glucose
- Abnormal Lab Findings - Increased
- Anti-B2-glycoprotein I (Lab)
- Anti-cardiolipin (Lab)
- Anti-Cytoplasmic ribosomes antibodies (Lab)
- Anti-DNA antibody (double stranded) (Lab)
- Anti-DNA-Histone (DNP) antibodies (Lab)
- Anti-Histone antibody (Lab)
- Anti-mitochondrial antibodies/AMA (Lab)
- Anti-neutrophilic/cytoplasm antibody (ANCA) (Lab)
- Anti-PCNA antibody (Lab)
- Antiphospholipid antibodies (Lab)
- Anti-Ribosomal protein S10 (Lab)
- Anti-RNA antibody/Nrnp (Lab)
- Anti-RNA/ENA Sm (Smith) antibody (Lab)
- Anti-RNP (U1RNP) antibody (Lab)
- Anti-Roux in La (nucleotides) (Lab)
- Anti-SCL-70 (antinucleotide) (Lab)
- Anti-SSA (Ro) antibody/cytoplasm antigen (Lab)
- Anti-SSB (La) antibodies/Cytoplasm antigen (Lab)
- Anti-ssDNA (single stranded) antibody (Lab)
- Acute lymphopenia/transient
- Alpha-1-antitrypsin globulin level (Lab)
- Amylase, serum (Lab)
- ANA, homogenous/serum (Lab)
- ANA, peripheral/serum (Lab)
- ANA, speckled (Lab)
- ANA/Antinuclear antibody/Fluorescent ANA (Lab)
- Biologic false positive (serology) (Lab)
- Bleeding time, Duke (Lab)
- BUN/Blood urea nitrogen (Lab)
- Creatine, serum (Lab)
- Cryoglobulins (Lab)
- Direct Coombs test (Lab)
- Eosinophiles (Lab)
- Fibrin Split Products/FSP/Dimers/Monomers (Lab)
- Fibrinogen, plasma (Lab)
- Gamma globulin (Lab)
- Globulin, serum (Lab)
- Glycoproteins (Lab)
- IGA/Immunoglobulin A (Lab)
- IGD/Immunoglobulin D (Lab)
- IGG/Immunoglobulin G (Lab)
- IGM/Immunoglobulin M (Lab)
- LDH isoenzyme 4 (Lab)
- LDH/Lactic Dehydrogenase (Lab)
- LE Prep/Lupus erythematosis cell prep (Lab)
- Monocytes (Lab)
- Monocytosis
- P-ANCA antibodies (Lab)
- Plasma cells, blood (Lab)
- Potassium, serum (Lab)
- PTT/Partial Thromboplastin Time/Activated PTT (Lab)
- Rheumatoid factor (Lab)
- Sed Rate/ESR/Sedimentation rate (Lab)
- Serologic syphilis test/STS/VDRL/Hinton (Lab)
- Thromboplastin generation time (Lab)
- Viscosity, serum (Lab)
- Vitamin B12 binding capacity (Lab)
- URINE Casts erythrocytes
- URINE Casts/Protein casts
- URINE Creatine
- URINE Lactic dehydrogenase
- URINE Monocytes
- URINE Mucopolysaccharides
- URINE Myoglobin
- URINE Protein (albumin)
- URINE Red blood cells
- CSF Protein
- SYNOVIAL Antinuclear antibodies
- SYNOVIAL Lymphocytes
- PLEURAL Adenosine deaminase/ADA
- PLEURAL Antinuclear antibodies
- PLEURAL Eosinophiles
Diagnostic Test Results[previous][top][next]
- Other Tests & Procedures
- Pathology
- PATH/Arteritis/immune complex deposition
- PATH/Periarterial sclerosis/Tissue specimen
- BX/Skin biopsy/Cutaneous vasculitis/leukoclastic
- BX/Skin biopsy/Leukoclastic vasculitis
- BX/Renal glomerulous cellular infiltrate
- PATH/Cellular necrosis/pathology tissue specimen
- PATH/Collagen swelling/tissue specimen
- PATH/Fibrinoid degeneration/tissue
- PATH/Granulomatous tissue/specimen
- X-RAY
- Xray/Chest abnormal
- Xray/Subcutaneous ossification centers/calcification
- Xray/Calcification in fingertips
- Xray/Muscle calcification
- Xray/Soft tissue calcification/muscle/subcutaneous
- Xray/Bilateral basilar infiltrate/Chest
- Xray/Chest/Lung fields/Abnormal
- Xray/Pleural fluid/Chest
- Xray/Odontoid erosion/Neck
- Xray/Periarticular knee calcifications
- Xray/Ribs inferior bone resorption
- Xray/Ribs, notching margins
Associated Diseases & Rule outs[previous][top][next]
- Rule Outs
- Acne rosacea
- Adult Still's disease/RA presentation
- Ascariasis, pulmonary larval infestation
- Bronchiolitis obliterans
- Collagenosis, unclassified
- Fibromyositis/fibromyalgia syndrome
- Glomerulonephritis, acute
- Goodpasture's syndrome
- Juvenile rheumatoid arthritis/chronic
- Lupus, discoid, chronic
- Mixed connective tissue disease (MCTD)
- Paroxysmal cold hemoglobinuria
- Pemphigoid, bullous
- Pemphigus
- Polyarteritis nodosa
- Psoriasis
- Rheumatic fever
- Rheumatoid arthritis
- Scleroderma, progressive systemic
- Tinea corporis
- Associated Disease & Complications
- Abortion, habitual (spontaneous,recurrent)
- Abortion/miscarriage
- Acute renal failure
- Alopecia areata
- Alopecia totalis/universalis
- Amyloidosis, secondary
- Amyloidosis, systemic
- Anemia
- Anemia of chronic disease
- Anemia, aplastic
- Anergic status
- Anticardiolipin syndrome
- Aortic regurgitation
- Aphthous stomatitis/aphthous oral lesions
- Arthritis
- Aspergillosis, invasive pulmonary type
- AV node lesion/infiltrate
- Avascular necrosis bone/process
- Azotemia in Elderly
- Azotemia/Acute
- Bone Marrow Fibrosis
- Cardiomyopathy
- Cardiomyopathy, secondary
- Cellular immunity defect/deficiency
- Cerebral Angiitis syndrome
- Cerebral thrombosis
- Cerebral vascular accident
- Chronic hives/urticaria
- Circulating anticoagulants disorder (Lab)
- Circulating coagulation inhibitor status
- CNS disease/involvement
- Collagen disease
- Collagen vascular disease
- Constrictive pericarditis/chronic
- Convulsions (grand mal)
- Cryptococcal meningitis
- Cryptococcosis, disseminated
- Cutaneous vasculitis
- CVA Hematologic disorders/Cause
- CVA Inflammatory disorders/cause
- Dacryoadenitis, acute
- Dementia
- Depression
- Depression, reactive
- Dermatitis/Chronic rash
- Dermatomyositis
- Disseminated intravascular coagulation
- Eclampsia of pregnancy
- Encephalopathy/CNS effect
- Eosinophilia
- Erythema multiforme
- Esophageal candidiasis
- Esophageal motility disorder
- Facial nerve palsy/secondary
- Glomerulonephritis, acute
- Glomerulonephritis, membranous
- Glomerulonephritis, rapidly progressive
- Glomerulonephritis/Glomerulitis
- Guillain-Barre syndrome
- Hallucinations
- Hemolysis anemia/acute/active
- Hemolytic Anemia
- Hemolytic anemia/autoimmune
- Hemolytic-uremic syndrome
- Hyperglobulinemia
- Hyperkalemia
- Hypersplenism
- Hypertension
- Hypocomplementemia
- Hypogammaglobulinemia
- Hypogammaglobulinemia, acquired
- Inappropriate ADH secretion syndrome
- Inflammatory myopathy
- Interstitial lung involvement/manifestation
- Intestinal/gut lymphoma
- Iritis
- Leukocytoclastic angiitis
- Livedo reticularis
- Lupus cerebritis
- Lupus erythematosis, systemic
- Lupus nephritis
- Lupus, discoid, chronic
- Microangiopathic anemia/disease
- Mitral regurgitation
- Mononeuritis, multiplex
- Myasthenia gravis
- Myelitis, transverse
- Myelofibrosis
- Myelofibrosis secondary
- Myocarditis
- Nasal septum perforation
- Neonatal thrombocytopenia
- Nephritis, interstitial
- Nephritis, non-allergic interstitial
- Nephrosis/secondary disease
- Nocardia, pulmonary
- Organic brain syndrome
- Pancreatitis, acute
- Pancytopenia
- Pericardial effusion
- Pericarditis, acute
- Peripheral neuropathy
- Peritonitis. acute
- Peritonitis/aseptic
- Photosensitivity dermatitis
- Platelet manifestation/defect
- Pleural Effusion
- Pleurisy
- Pleurisy with effusion
- Pleuropericarditis
- Pneumococcus infection
- Pneumocystis cariini pneumonia
- Pneumonia, lymphoid interstitial
- Pneumonia, pneumococcal
- Pneumonia/Bronchopneumonia
- Polyarteritis nodosa
- Polyarthritis in Children
- Polyarthritis syndrome/Multiple joints/weeks
- Polyneuritis
- Presentation/Pancreatitis in kids/recurrent
- Protein losing enteropathy
- Proteinuria
- Pseudotumor cerebri
- Psychosis
- Pulmonary Interstitial fibrosis, secondary
- Raynaud's disease
- Raynaud's syndrome
- Renal tubular acidosis, distal
- Renal tubule acidosis, acquired
- Renal vasculitis
- Retinal hemorrhage
- Retroperitoneal hemorrhage
- Scarring alopecia
- Scleritis/Episcleritis
- Serositis
- Sjogren's sicca syndrome
- Stomatitis
- Tamponade, cardiac/pericardial
- Telangiectasia
- Thrombocytopenia
- Thrombocytopenia in Children
- Toxoplasmosis, disseminated
- Transient ischemic attack/cerebral
- Transverse myelitis, subacute
- Urticaria/hives
- Hypersensitivity/Leukoclastic Vasculitis
- Anemia in Elderly
- Recurrent Meningitis
- Monoarthritis Acute
- PolyArthritis
- Proteinuria in Children
- Proteinuria in Elderly
- Disease Synergy - Causes
- Synergy/General stress
- Synergy/Immunizations/vaccinations
- Synergy/On medications/medication
- Synergy/Sunlight exposure
- Rule Outs
Disease Mechanism & Classification[previous][top][next]
- Class
- CLASS/Vascular Small Vessel Disorder
- CLASS/Multisystem/organ involvement/pathology (ex)
- CLASS/Systemic/no comment (category)
- Pathophysiology
- Pathophysiology/Circulating immune complex
- Pathophysiology/Cytokine gene polymorphism
- Pathophysiology/Genomic indentifiers (polymorphism/snip/mutations)
- Pathophysiology/Multisystem disease
- Pathophysiology/Urticaria/Circulating immune complex
- Pathophysiology/Hypersensitivity Vasculitis
- Pathophysiology/Leukoclastic Vasculitis
- Pathophysiology/Hemolytic process/effect
- Pathophysiology/Hypercoaguability
- Pathophysiology/Mechanical Hemolysis
- Pathophysiology/CD4/T-cell synovitis
- Pathophysiology/Nephritis/tubulointerstitial
- Pathophysiology/Renal manifestations/involvement
- Pathophysiology/Anti-Chromosomal DNA antibodies
- Pathophysiology/Apoptosis/cell death deregulation/genetic
- Pathophysiology/Chemotaxis failure/phagocytes/effect
- Pathophysiology/Immune physiology/defective
- Pathophysiology/Mucin/small duct (mucus glands) def
- Pathophysiology/Ischemic optic neuritis
- Process
- PROCESS/Allergy/collagen/autoimmune (category)
- PROCESS/Collagen disease (ex)
- PROCESS/Ethnic predilection (ex)
- PROCESS/Great imitators/diseases (ex)
- PROCESS/Hereditary/Genetic predisposition (ex)
- PROCESS/Inflammatory/Granulomatous disease (ex)
- PROCESS/Photodermatosis (ex)
- PROCESS/Glomerular lesions/disorder (ex)
- PROCESS/Granulomatous Disease
- Class
-
- Synonym
- Synonym/SLE
- Synonym
Treatment[previous][top][next]
- Drug Therapy - Contraindication
- RX/Gamma interferon (Actimmune)
- RX/Procainamide (Pronestyl)
- Drug Therapy - Indication
- RX/Azathioprine (Imuran)
- RX/Hydroxychloraquin (Plaquenil)
- RX/Immune-suppression
- RX/Prednisone (Deltasone)
- SX/Stem cell transplant potential/future
- Other Treatments
- TX/Avoid sunlight exposure
- TX/Platelet transfusion
- Drug Therapy - Contraindication
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