Disease Information for Lucey-Driscoll Syndrome

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Clinical Manifestations
Signs & Symptoms
Jaundice of newborn
Disease Progression
Course/Short/brief/self-limited
Demographics & Risk Factors
Population Group
Infant
Population/Pediatrics population
Sex & Age Groups
Population/Infant
Laboratory Tests
Abnormal Lab Findings - Increased
Bilirubin, serum (Lab)
Indirect bilirubin (Lab)
Associated Diseases & Rule outs
Associated Disease & Complications
Kernicterus
Disease Mechanism & Classification
Process
PROCESS/Autosomal recessive disorder (ex)
PROCESS/Hereditofamilial (category)
PROCESS/INCIDENCE/Rare disease (ex)
PROCESS/Metabolic/storage disorder (category)
PROCESS/Inherited bilirubin metabolism disorder (ex)
Definition

Lucey-Driscoll syndrome is an autosomal recessive metabolic disorder affecting enzymes involved in bilirubin metabolism.

It is one of several disorders classified as a transient familial neonatal unconjugated hyperbilirubinemia.

The common cause is congenital, but it can also be caused by maternal steroids passed on through breast milk to the newborn. It is different from breast milk jaundice (breast-fed infants have higher bilirubine levels than formula-fed ones).

Lucey-Driscoll syndrome has an autosomal recessive pattern of inheritance.

A defect in the UGT1A1-gene, also linked to Crigler-Najjar syndrome and Gilbert's syndrome, is responsible for the congenital form of Lucey-Driscoll syndrome.

[Wikipedia online website 2008]

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External Links Related to Lucey-Driscoll Syndrome
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PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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