- Differential Diagnosis
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- Disease Information
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Disease Information for Lucey-Driscoll Syndrome
Available only to registered users.
- 13 possible findings found
- Clinical Manifestations
- Signs & Symptoms
- Jaundice of newborn
- Disease Progression
- Demographics & Risk Factors
- Population Group
- Population/Pediatrics population
- Sex & Age Groups
- Laboratory Tests
- Abnormal Lab Findings - Increased
- Bilirubin, serum (Lab)
- Indirect bilirubin (Lab)
- Associated Diseases & Rule outs
- Associated Disease & Complications
- Disease Mechanism & Classification
- PROCESS/Autosomal recessive disorder (ex)
- PROCESS/Hereditofamilial (category)
- PROCESS/INCIDENCE/Rare disease (ex)
- PROCESS/Metabolic/storage disorder (category)
- PROCESS/Inherited bilirubin metabolism disorder (ex)
Lucey-Driscoll syndrome is an autosomal recessive metabolic disorder affecting enzymes involved in bilirubin metabolism.
It is one of several disorders classified as a transient familial neonatal unconjugated hyperbilirubinemia.
The common cause is congenital, but it can also be caused by maternal steroids passed on through breast milk to the newborn. It is different from breast milk jaundice (breast-fed infants have higher bilirubine levels than formula-fed ones).
Lucey-Driscoll syndrome has an autosomal recessive pattern of inheritance.
A defect in the UGT1A1-gene, also linked to Crigler-Najjar syndrome and Gilbert's syndrome, is responsible for the congenital form of Lucey-Driscoll syndrome.
[Wikipedia online website 2008]
- External Links Related to Lucey-Driscoll Syndrome
- PubMed (National Library of Medicine)
- NGC (National Guideline Clearinghouse)
- Medscape (eMedicine)
- Harrison's Online (accessmedicine)
- NEJM (The New England Journal of Medicine)