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Disease Information for Limbic encephalopathy/paraneoplastic

Clinical Manifestations
Signs & Symptoms: Abnormal movements/involuntary; Confusion/agitation on exam; Confusion/Disoriented; Irritability/short tempered; Memory Loss in Elderly; Near recall/memory deficit/defect; Personality change; Rapidly progressive dementia; Seizures; Short term memory loss; Temporal lobe signs
: Agitation; Neuropsychiatric symptoms
: Opsoclonus/chaotic eye movements
Clinical Presentation & Variations: Presentation/Progressive Dementia
Disease Progression: Course/Chronic disorder; Course/Chronic only; Course/Subacute
Demographics & Risk Factors
Established Disease Population: Patient/Cancer
Laboratory Tests
Abnormal Lab Findings (Non Measured): Anti-Neuron [ANNA ] Paraneoplastic antigens (1,2,2a) abnormalities
: Paraneoplastic Antibody Panel (Lab)
Abnormal Lab Findings - Increased: Anti-CRMP5/Neuronal Cytoplasm antibody; Anti-GAD antibodies; Anti-Glutamic Acid decarboxylase antibodies/GAD; Anti-Hu/ANNA-IIA Paraneoplastic antigen (Lab); Anti-Ma/Neuronal antibodies (Lab); Anti-Purkinje/APCA/Anti-yo titer (Lab); Anti-Ri/ANNA-2 paraneoplastic antigen (Lab); Anti-Ta/Neuronal antibodies (Lab)
: CSF Anti-Hu (ANNA 2a) antibodies
Diagnostic Test Results
Pathology: PATH/Brain/multifocal lesions/cysts/grey and white matter
CT Scan: MRI/Head Bilateral temporal lobe lesions; MRI/Head Brain Abnormal; MRI/Head Brain FLAIR Image Abnormal; MRI/Head Gadolium contrast abnormal; MRI/Head Scan Abnormal; MRI/Head T2 and fluid -attenuated inversion recovery; PET Scan/Head abnormal
Associated Diseases & Rule outs
Associated Disease & Complications: Amnesia; CNS disease/involvement; Dementia; Depression; Encephalopathy/CNS effect; Limbic encephalopathy syndrome/paraneoplastic; Partial complex seizure; Seizure disorder (epilepsy)
Disease Mechanism & Classification
Class: CLASS/Neurologic (category)
Process: PROCESS/Autoimmune disorder (ex); PROCESS/Degenerative/necrosis disorder (category); PROCESS/Neoplastic (category); PROCESS/Paraneoplastic disorder (ex); PROCESS/Paraneoplastic neurologic disorder; PROCESS/Use/Age/atrophic disorder (category)
Treatment
Drug Therapy - Indication: RX/Gamma globulin (intravenous, high dose); RX/High dose Steroid trial [six weeks]; RX/Immune-suppression; RX/Immunoglobulin infusion
Other Treatments: TX/Plasmapheresis/exchange.
Definition: Be the first to add a definition for Limbic encephalopathy/paraneoplastic
External Links Related to Limbic encephalopathy/paraneoplastic: Google; Wikipedia; Merck; Images; PubMed (National Library of Medicine); NGC (National Guideline Clearinghouse); Medscape (eMedicine); Harrison's Online (accessmedicine); NEJM (The New England Journal of Medicine)

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