Disease Information for Levodopa (Larodopa/Dopar) Administration/Toxicity

Clinical Manifestations
Signs & Symptoms
Lactation suppression/nursing mother/complaint
Tachycardia/Fast heart rate
Hair loss
Non-scarring Alopecia/balding
Impotence, relative
Choreoathetoid movement
Delirium/Agitated delirium
Myoclonus/Myoclonic jerks on exam
Nightmares/excess dreaming (Paroniria)
Manic behavior
Coca-Cola dark (coffee colored) urine
Laboratory Tests
Abnormal Lab Findings (Non Measured)
Indirect Coombs Test Abnormal
URINE Color Brown
Abnormal Lab Findings - Decreased
Folic acid/Folate (Lab)
Prolactin (Lab)
Pyridoxine/Vitamin B6 (Lab)
Abnormal Lab Findings - Increased
Direct Coombs test (Lab)
Glucose, blood (Lab)
Growth hormone/STH, plasma (Lab)
Insulin level (Lab)
Thyroxin/T4 (Lab)
Diagnostic Test Results
Other Tests & Procedures
TEST/TRH/TSH reponse/sluggish response
Isotope Scan
Isotope/RAI uptake/quantitative high thyroid (I 123)
Associated Diseases & Rule outs
Associated Disease & Complications
Acute gastroenteritis
Drug induced Baldness/Alopecia
Drug Induced Choreoathetosis
Drug induced Diarrhea.
Drug induced Dreaming/nightmares (Paroniria)
Drug induced Hyperglycemia
Drug induced Impotence.
Drug induced Movement disorder
Impotence/Erectile dysfunction disorder
Vitamin B6/Pyridoxine deficiency
Oculogyric Crisis
Disease Synergy - Causes
Synergy/High Protein diet/intake
Disease Mechanism & Classification
DRUG/Anti-parkinsons medication (examples)
DRUG/Dopamine agonist/CNS drug (example)
DRUG/Dopaminergic Anti-Parkinson's medication
DRUG/Serotonin reuptake inhibitor/CNS effect
Pathophysiology/Decrease TSH synthesis
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
( ) 2Amino 3 )3 4 dihydroxyphenyl)propanoic Acid, ( ) 3 (3 4 Dihydroxyphenyl) L alanine, 3 (3 4 Dihydroxyphenyl) L alanine, 3 Hydroxy L tyrosine, beta (3 4 Dihydroxyphenyl) L alanine, DOPA A L, L 3 4 Dihydroxyphenylalanine, L 3 hydroxytyrosine, L beta (3 4 Dihydroxyphenyl)alanine, L Dopa, L Dopa Levodopa, L dopa preparation, L( ) Dopa, Levodopa, Levodopa (product), Levodopa (substance), LEVODOPA PREPARATION, Brand name/Atamet (Levodopa), Brand name/Dopar (Levodopa), Brand name/Larodopa (Levodopa), Brand name/Parcopa (Carbidopa-Levodopa), Brand name/Sinemet (Carbadopa-levodopa), Brand name/Stalevo comb (Carbidopa/Levodopa/Entacapone)
Drug Dosage
DRUG/Dose 100 mgm (Unit/Pill/Capsule size)
DRUG/Dose 500 mgm (Unit/Pill/Capsule size)
DRUG/Dose BID Medication
DRUG/Oral medication (ex)

Anti-parkinsonism drug;Dopamine precursor;oral preparation


Levodopa, which is converted in the body to dopamine, improves all of the major features of parkinsonism, including bradykinesia, but does not stop progression of the disorder. The most common early side effects of levodopa are nausea, vomiting, and hypotension, but cardiac arrhythmias may also occur. Dyskinesias, restlessness, confusion, and other behavioral changes tend to occur somewhat later and become more common with time. Levodopa-induced dyskinesias may take any conceivable form, including chorea, athetosis, dystonia, tremor, tics, and myoclonus. An even later complication is the "on-off phenomenon," in which abrupt but transient fluctuations in the severity of parkinsonism occur unpredictably but frequently during the day. The "off" period of marked bradykinesia has been shown to relate in some instances to falling plasma levels of levodopa. During the "on" phase, dyskinesias are often conspicuous but mobility is increased.



Levodopa therapy is contraindicated in patients with psychotic illness or narrow-angle glaucoma. It should not be given to patients taking monoamine oxidase A inhibitors or within 2 weeks of their withdrawal, because hypertensive crises may result. Levodopa should be used with care in patients with suspected malignant melanomas or with active peptic ulcers because of concerns that it may exacerbate these disorders.

[currentdxrx 2005 accessmedicine]


External Links Related to Levodopa (Larodopa/Dopar) Administration/Toxicity
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)