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Disease Information for Leuprolide (Lupron) Administration/Toxicity

Clinical Manifestations

Signs & Symptoms

Hot Flushes

Impotence, relative

Amenorrhea

Amenorrhea, secondary

Hot flashes

Laboratory Tests

Abnormal Lab Findings - Decreased

FSH/Follicle Stmulating Hormone/ICSH (Lab)

Associated Diseases & Rule outs

Associated Disease & Complications

Drug induced Impotence.

Eunuchism

Impotence/Erectile dysfunction disorder

Osteoporosis/osteopenia

Testicular atrophy

Metabolic Bone Disease

Disease Mechanism & Classification

Drugs

DRUG/Anti-androgen effect

DRUG/Chemotherapeutics/cancer drugs/etc (category)

DRUG/Gonadotropin-releasing agonist drug (example)

DRUG/Hormonal agent/derivative medication (example)

DRUG/Hormonal agents/cancer chemotherapy (example)

DRUG/LHRH inhibitor effect/analog (agonist)

DRUG/Prostate cancer use (ex)

DRUG/Teratogenic/OBGYN Class X/Pregnancy DANGER

Pathophysiology

Pathophysiology/Hypogonadotrophic hypogonadism

Pathophysiology/Osteoporosis Secondary

Process

PROCESS/Medication/Drug (CONFIRM dose/before treatment)

Synonyms

Synonym

6 D Leucine 9 (N ethyl L prolinamide) 1 9 luteinizing Hormone releasing Factor (Pig), 6 D Leucine 9 (N ethyl L prolinamide) 10 deglycinamide Luteinizing Hormone Releasing Factor (Pig), LEUP, Leuprolide, Leuprolide (Obsolete), leuprolide acetate, LEUPROLIDE PREPARATION, Leuprorelin, Leuprorelin (product), Leuprorelin (substance), Luteinizing hormone releasing factor (pig) 6 D leucine 9 (N ethyl L prolinamide) 10 deglycinamide, Brand name/Lupron (Leuprolide), Brand name/Oaklide (Leuprolide)

Treatment

Drug Dosage

DRUG/.$$$$$ Most Expensive

DRUG/Injectable medication (parenteral)

DRUG/Intramuscular injection RX

DRUG/Orally ineffective drug

DRUG/Subcutaneous administration medication

Definition

GnRH analog;Functionally gonadotropin antagonist as releasing hormone receptor is exhausted ;used in cancer chemotherapy biologic activity modifier in prostate cancer;

also used in endometriosis

(Edit)

External Links Related to Leuprolide (Lupron) Administration/Toxicity

PubMed (National Library of Medicine)

NGC (National Guideline Clearinghouse)

Medscape (eMedicine)

Harrison's Online (accessmedicine)

NEJM (The New England Journal of Medicine)

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